Drug loaded homogeneous electrospun PCL/gelatin hybrid nanofiber structures for anti-infective tissue regeneration membranes

YesInfection is the major reason for guided tissue regeneration/guided bone regeneration (GTR/GBR) membrane failure in clinical application. In this work, we developed GTR/GBR membranes with localized drug delivery function to prevent infection by electrospinning of poly(ε-caprolactone) (PCL) and gelatin blended with metronidazole (MNA). Acetic acid (HAc) was introduced to improve the miscibility of PCL and gelatin to fabricate homogeneous hybrid nanofiber membranes. The effects of the addition of HAc and the MNA content (0, 1, 5, 10, 20, 30, and 40 wt.% of polymer) on the properties of the membranes were investigated. The membranes showed good mechanical properties, appropriate biodegradation rate and barrier function. The controlled and sustained release of MNA from the membranes significantly prevented the colonization of anaerobic bacteria. Cells could adhere to and proliferate on the membranes without cytotoxicity until the MNA content reached 30%. Subcutaneous implantation in rabbits for 8 months demonstrated that MNA-loaded membranes evoked a less severe inflammatory response depending on the dose of MNA than bare membranes. The biodegradation time of the membranes was appropriate for tissue regeneration. These results indicated the potential for using MNA-loaded PCL/gelatin electrospun membranes as anti-infective GTR/GBR membranes to optimize clinical application of GTR/GBR strategies

Neanderthal behaviour, diet, and disease inferred from ancient DNA in dental calculus

Recent genomic data have revealed multiple interactions between Neanderthals and modern humans, but there is currently little genetic evidence regarding Neanderthal behaviour, diet, or disease. Here we describe the shotgun-sequencing of ancient DNA from five specimens of Neanderthal calcified dental plaque (calculus) and the characterization of regional differences in Neanderthal ecology. At Spy cave, Belgium, Neanderthal diet was heavily meat based and included woolly rhinoceros and wild sheep (mouflon), characteristic of a steppe environment. In contrast, no meat was detected in the diet of Neanderthals from El Sidrón cave, Spain, and dietary components of mushrooms, pine nuts, and moss reflected forest gathering. Differences in diet were also linked to an overall shift in the oral bacterial community (microbiota) and suggested that meat consumption contributed to substantial variation within Neanderthal microbiota. Evidence for self-medication was detected in an El Sidrón Neanderthal with a dental abscess and a chronic gastrointestinal pathogen (Enterocytozoon bieneusi). Metagenomic data from this individual also contained a nearly complete genome of the archaeal commensal Methanobrevibacter oralis (10.2× depth of coverage)-the oldest draft microbial genome generated to date, at around 48,000 years old. DNA preserved within dental calculus represents a notable source of information about the behaviour and health of ancient hominin specimens, as well as a unique system that is useful for the study of long-term microbial evolution

Discretionary power of the judge and breach of contract : a comparative study of french and german law

La question de la mesure du pouvoir du juge s’impose lorsqu’on souhaite comparer l’étendue des pouvoirs du juge dans différents ordres juridiques donnés. Or force est de constater que les pouvoirs du juge sont appréhendés sous diverses notions dans les systèmes juridiques nationaux : il est fait tour à tour référence au pouvoir souverain d’appréciation du juge du fond, au pouvoir facultatif du juge, à son pouvoir modérateur, discrétionnaire, arbitraire. Toute la difficulté de la comparaison réside dans l’absence d’un instrument de mesure uniforme. A l’échelle supranationale, le terme anglais « Judicial discretion » constitue souvent le point de départ de discussions et d’analyses comparatives sur les pouvoirs du juge. Cette notion à forte coloration doctrinale sert de critère de mesure de l’ampleur des pouvoirs du juge dans les systèmes juridiques respectifs. On entend par pouvoir discrétionnaire le pouvoir donné au juge de choisir entre deux ou plusieurs décisions également conformes à la légalité. Le critère du libre choix est au cœur de la notion du pouvoir discrétionnaire du juge. Le pouvoir discrétionnaire constitue ainsi la forme la plus libre du pouvoir exercé par le juge. Bien qu’elle fasse office de dénominateur commun, la notion de pouvoir discrétionnaire est diversement entendue en droits français et allemand. Il en va ainsi en particulier à propos des notions-cadre et standards : ces derniers confèrent-ils au juge un pouvoir discrétionnaire ? Les réponses divergent d’un système à l’autre, ce qui a un impact sur l’image qu’on se fait des pouvoirs du juge. Une fois ces malentendus dissipés, reste à déterminer la part faite à ce pouvoir dans les suites de l’inexécution du contrat : exécution forcée en nature, délai d’exécution et révision, résolution.How to measure a judge’s power? This question is necessary, when it comes to comparing the extent of the powers of a judge in various given jurisdictions. It has tobe noted, that the powers of a judge are gathered under diverse notions in national legal systems: successively, references are made to the sovereign judicial authority of the judge, the unfettered discretion of the lower courts, the authority to modify the legal situation, the discretionary power, the arbitrary power. The challenge in the comparison lies in the absence of a uniform measuring tool. On a supranational level,the English term“Judicial discretion”is very frequently the starting point for discussions and comparative analyses regarding the judge’s power. This notion serves as criteria to measure the extent of the judge’s powers in the respective legal systems. Discretionary power means the power given to the judge to choose between different decisions that are all conformable to law. The criterion of freedom of choice is in the center of the judge’s discretionary power. The discretionary power is the most powerful authority of the judge. It is common sense that the judge has a discretionarypower but the meaning of this term is differently interpretated by the national law,especially by the German and French law systems. This applies especially to the standards provisions or“open-textured”provisions : do they grant the judge a discretionary power? The answers vary from one system to the other, which has an impact on the image one has on the judge’s powers. Once these misunderstandings are dispelled, it remains to determine the proportion this power has in the consequences of the non-performance of contract: specific performance, delay inexecution, revision and termination

Le dispositif de protection contre les clauses abusives : regards croisés franco-allemands

Signat Carine. Le dispositif de protection contre les clauses abusives : regards croisés franco-allemands. In: Revue internationale de droit comparé. Vol. 68 N°4,2016. pp. 863-882

Les sanctions de l’inexécution : Rapport sur les textes internationaux et les principes européens

International audienc

Personale Differenzierung im Kaufrecht. Rechtsvergleichende Studie unter Einbeziehung deutscher und französischer Regelungen und internationaler Regelwerke (CISG, UNIDROIT PICC, CESL, CFR)

Compte-rendu d’une thèse allemande: Lydia Beil : Personale Differenzierung im Kaufrecht. Rechtsvergleichende Studie unter Einbeziehung deutscher und französischer Regelungen und internationaler Regelwerke (CISG, UNIDROIT PICC, CESL, CFR), Mohr Siebeck: Tübingen 2018. 337 S