17 research outputs found
Cerebrospinal Fluid Tau Protein Levels and F-18-Fluorodeoxyglucose Positron Emission Tomography in the Differential Diagnosis of Alzheimer's Disease
Aims: In this study, we aimed to compare cerebrospinal fluid (CSF) levels of total tau (t-tau), phosphorylated tau (p-tau(181)) and positron emission tomography with F-18-fluorodeoxyglucose (FDG-PET) in the differential diagnosis of Alzheimer's disease (AD) under clinical conditions. Method: In a cross-sectional, blinded, single-center study, we examined a sample of 75 unselected memory clinic patients with clinical diagnoses of dementia of Alzheimer type (DAT; n = 24), amnestic mild cognitive impairment (MCI; n = 16), other dementias (n = 13) and nondemented controls (n = 22). Discriminative accuracy, sensitivity and specificity were calculated and compared using ROC analyses. Results: p-tau(181) and FDG-PET were comparable in separating DAT from controls (sensitivity: 67 vs. 79%; specificity: 91% for both) and patients with other dementias (sensitivity: 71 vs. 79%; specificity: 100% for both). The sensitivity of p-tau 181 in differentiating MCI patients from controls was significantly (p < 0.05) superior to that of FDG-PET (75 vs. 44%) at a comparably high specificity (82 vs. 91%); t-tau measures were less accurate in all analyses. Conclusions: FDG-PET and CSF p-tau(181) levels are able to discriminate DAT in heterogeneous and unselected samples with a high accuracy. CSF p-tau(181) might be somewhat superior for a sensitive detection of patients with MCI. Copyright (C) 2010 S. Karger AG, Base
ΠΠ΅Ρ Π°Π½ΠΈΠ·ΠΌ ΡΠ°ΠΌΠΎΠ²ΠΎΠ·Π³ΠΎΡΠ°Π½ΠΈΡ ΡΠ³Π»Ρ
Π ΡΠ°Π±ΠΎΡΠ΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΎΡΠ΅ΡΡΠ° Π·Π°ΡΠΎΠΆΠ΄Π΅Π½ΠΈΡ ΠΎΡΠ°Π³Π° ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ ΠΏΠΎΠΆΠ°ΡΠ° ΠΈ Π½Π°ΠΌΠ΅ΡΠ΅Π½Ρ ΠΏΡΡΠΈ ΠΌΠΎΠ±ΠΈΠ»ΡΠ½ΠΎΠ³ΠΎ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π²Π΅ΡΠΎΡΡΠ½ΠΎΡΡΠΈ Π΅Π³ΠΎ Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ ΠΈΠ»ΠΈ Π½Π°Π»ΠΈΡΠΈΡ. ΠΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌ ΡΠ°ΠΌΠΎΠ²ΠΎΠ·Π³ΠΎΡΠ°Π½ΠΈΡ ΡΡΠΈΡΡΠ²Π°Π΅Ρ ΠΏΡΠΎΡΠ΅ΡΡΡ ΡΠ΅ΠΏΠ»ΠΎΠ²ΡΠ΄Π΅Π»Π΅Π½ΠΈΡ ΠΏΡΠΈ Π½Π°Π³ΡΠ΅Π²Π°Π½ΠΈΠΈ ΡΠ³Π»Ρ, Π²ΡΠ΄Π΅Π»Π΅Π½ΠΈΡ Π»Π΅ΡΡΡΠΈΡ
ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ², ΡΡΠ΅ΡΠΈΠ½ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΡΠ΅ΠΆΠΈΠΌΠ° Π΄ΠΎΡΡΡΠΏΠ° ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π° Π² ΠΎΡΠ°Π³ ΡΠ΅Π°ΠΊΡΠΈΠΈ Π² Ρ
ΠΎΠ΄Π΅ Π΅Π³ΠΎ ΡΠ²ΠΎΠ»ΡΡΠΈΠΈ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΌΠ°ΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΡΠ°ΠΌΠΎΠ²ΠΎΠ·Π³ΠΎΡΠ°Π½ΠΈΡ ΡΠ³Π»Ρ ΡΡΠ΅Ρ
ΠΌΠ°ΡΠΎΠΊ ΡΠ³Π»Ρ - Π°Π½ΡΡΠ°ΡΠΈΡ, ΠΊΠΎΠΊΡΡΡΡΠΈΠΉΡΡ, ΠΆΠΈΡΠ½ΡΠΉ, ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ ΡΠ°ΡΡΠ΅Ρ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΠ½ΡΡ
ΠΏΠΎΠ»Π΅ΠΉ Π½Π° ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠΈ ΠΎΡΠ°Π³Π° ΡΠ°ΠΌΠΎΠ²ΠΎΠ·Π³ΠΎΡΠ°Π½ΠΈΡ, ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ ΠΊΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΡΠ»ΠΎΠ²ΠΈΡ. ΠΠ»Ρ ΠΌΠΎΠ±ΠΈΠ»ΡΠ½ΠΎΠ³ΠΎ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π²Π΅ΡΠΎΡΡΠ½ΠΎΡΡΠΈ Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ ΠΈΠ»ΠΈ Π½Π°Π»ΠΈΡΠΈΡ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ ΠΏΠΎΠΆΠ°ΡΠ° ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½ΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°ΡΡ Π±Π΅ΡΠΏΠΈΠ»ΠΎΡΠ½ΡΠ΅ Π»Π΅ΡΠ°ΡΠ΅Π»ΡΠ½ΡΠ΅ Π°ΠΏΠΏΠ°ΡΠ°ΡΡ.In this work simulation of spontaneous combustion of coal of three grades - anthracite, coking coal, fat in case of lack of oxygen supply and calculation of dynamics of the temperature fields on the surface was made, critical conditions of the hearth of spontaneous combustion were estimated. The mechanism takes into account the processes of heat release, the release of volatile products, cracking and changes in the mode of access of oxygen to the reaction center during its evolution