Development and In Vitro Characterization of Diacerein Loaded Chitosan–Chondroitin Sulfate Nanoemulgel for Osteoarthritis

The proficient functions of diacerein and anti-inflammatory polymers have been utilized to develop sustained release transdermal diacerein nanoemulgel for long-term osteoarthritis treatment by overcoming the deleterious outcomes of drugs associated with the oral route. Natural anti-inflammatory and biodegradable polymers like Chitosan (CHS) and chondroitin sulfate (CS) were used to formulate diacerein nanoparticles (DCR-NPs) through the ionic gelation method. Design Expert software was used for preparation of optimized preparation by investigating the impact of polymers and surfactant concentrations on particle size, PDI and entrapment efficiency employing Response Surface Methodology (RSM). DCR-NPs formulated using CHS, CS and Tween 80 in optimized concentrations depicted spherical nanoparticles with particle size of 320.0 ± 3 nm having PDI, zeta potential and entrapment efficiency of 0.3 ± 0.07, 40 ± 0.3 mV and 82 ± 4.16%, respectively. DCR-NPs were further analyzed for confirmation of electrostatic interactions between polymers and drug through Fourier transform-infrared spectroscopy (FTIR). In vitro studies show 95% release of DCR in 72 h exhibiting the Korsmeyer–Peppas model. For transdermal delivery, the nanoemulgel of optimized DCR-NPs was formulated utilizing argan oil as a permeation enhancer with intrinsic anti-inflammatory properties, providing a synergistic effect to the formulation. Nanoemulgel was characterized in terms of visual appearance, spreadability, drug content and rheological behavior providing sustained release of drug up to 4 days following Higuchi model with improved ex vivo permeation, confirmed by fluorescent microscopy. Concisely, DCR-nanoemulgel sustained the release of drug with good penetration and enhanced therapeutic properties owing to the presence of CHS, CS and argan oil possessing anti-inflammatory attributes

Exploiting recent trends for the synthesis and surface functionalization of mesoporous silica nanoparticles towards biomedical applications

International audienc

Enhanced Antimicrobial Activity of Silver Sulfadiazine Cosmetotherapeutic Nanolotion for Burn Infections

Burns are highly traumatizing injuries that can be complicated by various microbial infections, leading to morbidity and mortality. The ultimate goal of burn therapy is to prevent any microbial infection and rapid wound healing with epithelization. The current study aimed to develop and investigate the potential of nanoemulsion-based cosmetotherapeutic lotion of silver sulfadiazine (SSD) for increased antimicrobial activity to treat burn injuries. Silver sulfadiazine is the standard topical treatment for burn patients, but is allied with major limitations of poor solubility, low bioavailability, and other hematologic effects, hindering its pharmaceutical applications. The nanoformulation was fabricated through the ultrasonication technique and optimized by selecting various parameters and concentrations for the formation of water-in-oil (w/o) emulsion. The optimized formulation depicts a smaller particle size of 213 nm with an encapsulation efficiency of approx. 80%. Further, nanoemulsion-based SSD lotion by utilizing argan oil as a cosmetotherapeutic agent was prepared for scar massaging with improved permeation properties. The designed cosmeceutical formulation was characterized in terms of physical appearance, refractive index, particle size, encapsulation efficiency, and biocompatibility. The compatibility of the formulation ingredients were determined through FTIR (Fourier Transform Infrared Spectroscopy). The formulated nanolotion containing SSD demonstrated superior antimicrobial activities against different bacterial strains in comparison to commercialized burn creams

Enhanced Antimicrobial Activity of Silver Sulfadiazine Cosmetotherapeutic Nanolotion for Burn Infections

Burns are highly traumatizing injuries that can be complicated by various microbial infections, leading to morbidity and mortality. The ultimate goal of burn therapy is to prevent any microbial infection and rapid wound healing with epithelization. The current study aimed to develop and investigate the potential of nanoemulsion-based cosmetotherapeutic lotion of silver sulfadiazine (SSD) for increased antimicrobial activity to treat burn injuries. Silver sulfadiazine is the standard topical treatment for burn patients, but is allied with major limitations of poor solubility, low bioavailability, and other hematologic effects, hindering its pharmaceutical applications. The nanoformulation was fabricated through the ultrasonication technique and optimized by selecting various parameters and concentrations for the formation of water-in-oil (w/o) emulsion. The optimized formulation depicts a smaller particle size of 213 nm with an encapsulation efficiency of approx. 80%. Further, nanoemulsion-based SSD lotion by utilizing argan oil as a cosmetotherapeutic agent was prepared for scar massaging with improved permeation properties. The designed cosmeceutical formulation was characterized in terms of physical appearance, refractive index, particle size, encapsulation efficiency, and biocompatibility. The compatibility of the formulation ingredients were determined through FTIR (Fourier Transform Infrared Spectroscopy). The formulated nanolotion containing SSD demonstrated superior antimicrobial activities against different bacterial strains in comparison to commercialized burn creams