686 research outputs found

    Optimal Closed Loop Control of G2V/V2G Action Using Model Predictive Controller

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    This paper has developed a closed-loop control algorithm to operate the G2V/V2G action, tested under varying battery voltage conditions and load and source power differences. Under V2G action, to maintain total harmonic distortion under minimum level and grid frequency under the standard limit, a Model predictive controller (MPC) has been used to control the gate driver circuit of the inverter. The state space model of the plant has been created using the system identification toolbox, and the MPC Controller block has been designed using the Model Predictive Control Toolbox of MATLAB. The proposed methodology is tested using MATLAB/Simulink and OPAL-RT (OP4510) in a real-time environment. This methodology reduces %THD to less than 0.5%, improves waveform quality of grid voltage, inverter output voltage, grid current, and inverter output current to nearly 99%, and maintains the grid frequency in standard limit while in G2V/V2G action

    Fault Detection and Classification using Wavelet and ANN in DFIG and TCSC Connected Transmission Line

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    This paper presents fault detection and classification using Wavelet and ANN based methods in a DFIG-based series compensated system. The state-of-the art methods include Wavelet transform, Fourier transform, and Wavelet-neuro fuzzy methods-based system for fault detection and classification. However, the accuracy of these state-of-the-art methods diminishes during variable conditions such as changes in wind speed, high impedance faults, and the changes in the series compensation level. Specifically, in Wavelet transform based methods, the threshold values need to be adapted based on the variable field conditions. To solve this problem, this paper has proposed a Wavelet-ANN based fault detection method where Wavelet is used as an identifier and ANN is used as a classifier for detecting various fault cases. This methodology is also effective under SSR condition. The proposed methodology is evaluated on various fault and non-fault cases generated on an IEEE first benchmark model under varying compensation levels from 20% to 55%, impedance faults, and wind velocity from 6m/sec to 10m/sec using MATLAB/Simulink, OPALRT(OP4510) manufactured real-time digital simulator environment, Arduino board I/O ports communicating with external PC in which ANN model dumped, using Arduino support package of MATLAB. The preliminary results are compared with the state-of-the-art fault detection method, where the proposed method shows robust performance under varying field conditions

    Next-gen sequencing of multi-drug resistant Acinetobacter baumanii at Nashville General Hospital at Meharry

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    Background Acinetobacter baumannii is a nonfermentative Gram-negative bacillus, which easily acquires antibiotic resistance determinants and causes life-threatening nosocomial infections [1]. Multi-drug resistant (MDR) strains are common therefore, empirical treatment choices are limited. More knowledge is needed regarding genetic diversity patterns and resistance phenotypes in a given clinical setting. Our goal is to identify the resistance genotypes of A. baumanii at Nashville General Hospital and correlate them with MDR phenotypes [1]

    Downregulation of APOBEC3G by xenotropic murine leukemia-virus related virus (XMRV) in prostate cancer cells

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    <p>Abstract</p> <p>Background</p> <p>Xenotropic murine leukemia virus (MLV)-related virus (XMRV) is a gammaretrovirus that was discovered in prostate cancer tissues. Recently, it has been proposed that XMRV is a laboratory contaminant and may have originated via a rare recombination event. Host restriction factor APOBEC3G (A3G) has been reported to severely restrict XMRV replication in human peripheral blood mononuclear cells. Interestingly, XMRV infects and replicates efficiently in prostate cancer cells of epithelial origin. It has been proposed that due to lack off or very low levels of A3G protein XMRV is able to productively replicate in these cells.</p> <p>Findings</p> <p>This report builds on and challenges the published data on the absence of A3G protein in prostate epithelial cells lines. We demonstrate the presence of A3G in prostate epithelial cell lines (LNCaP and DU145) by western blot and mass spectrometry. We believe the discrepancy in A3G detection is may be due to selection and sensitivity of A3G antibodies employed in the prior studies. Our results also indicate that XMRV produced from A3G expressing LNCaP cells can infect and replicate in target cells. Most importantly our data reveal downregulation of A3G in XMRV infected LNCaP and DU145 cells.</p> <p>Conclusions</p> <p>We propose that XMRV replicates efficiently in prostate epithelial cells by downregulating A3G expression. Given that XMRV lacks accessory proteins such as HIV-1 Vif that are known to counteract A3G function in human cells, our data suggest a novel mechanism by which retroviruses can counteract the antiviral effects of A3G proteins.</p
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