11 research outputs found
Clinically Important Features of Porphyrin and Heme Metabolism and the Porphyrias
Heme, like chlorophyll, is a primordial molecule and is one of the fundamental pigments of life. Disorders of normal heme synthesis may cause human diseases, including certain anemias (X-linked sideroblastic anemias) and porphyrias. Porphyrias are classified as hepatic and erythropoietic porphyrias based on the organ system in which heme precursors (5-aminolevulinic acid (ALA), porphobilinogen and porphyrins) are chiefly overproduced. The hepatic porphyrias are further subdivided into acute porphyrias and chronic hepatic porphyrias. The acute porphyrias include acute intermittent, hereditary copro-, variegate and ALA dehydratase deficiency porphyria. Chronic hepatic porphyrias include porphyria cutanea tarda and hepatoerythropoietic porphyria. The erythropoietic porphyrias include congenital erythropoietic porphyria (Gűnther’s disease) and erythropoietic protoporphyria. In this review, we summarize the key features of normal heme synthesis and its differing regulation in liver versus bone marrow. In both organs, principal regulation is exerted at the level of the first and rate-controlling enzyme, but by different molecules (heme in the liver and iron in the bone marrow). We also describe salient clinical, laboratory and genetic features of the eight types of porphyria
Genetic factors that affect nonalcoholic fatty liver disease: A systematic clinical review
Sa1267 Characteristics of Patients With Anti-Tissue Transglutaminase Antibodies and Anti-Endomysial Antibodies: Data From NHANES 2009-2010
Mo1137 Racial Differences in Young Patients With Colorectal Cancer: A Population-Based Study in the United States
Liver disease in the Era of Coronavirus Disease 19 (COVID-19) pandemic
Coronavirus infections have caused outbreaks in humans: SARS-COV ((Severe Acute Respiratory Syndrome) and MERS-CoV (Middle East Respiratory Syndrome) resulting in significant mortality and morbidit
Mo1143 Is Lymph Node Ratio (LNR) a Prognostic Marker in Patients With Colon Cancer? A Study in National Cancer Institute's Surveillance Epidemiology, and End Results (SEER) Database
Evaluation of socioeconomic factors and achievement of sustained virologic response (SVR) in the treatment of hepatitis C virus (HCV)
Poster presented at: Aurora Scientific Day; May 24, 2017; Milwaukee, WI
Evalation of the Impact of the Implementation of a Specialty Pharmacy Program in the Treatment of Hepatitis C (HCV)
Conclusion: SVR (sustained virologic response) rates are comparable to clinical trials in this real-life clinical setting using a specialty pharmacy program. Those with HCV Genotype 1A had lower SVR rates post-medication completion, though it did not reach statistical significance. There was no difference in SVR rates between previously treated and treatment-naive patients