22 research outputs found
Loss of PINK1 Increases the Heart's Vulnerability to Ischemia-Reperfusion Injury.
Get PDFMutations in PTEN inducible kinase-1 (PINK1) induce mitochondrial dysfunction in dopaminergic neurons resulting in an inherited form of Parkinson's disease. Although PINK1 is present in the heart its exact role there is unclear. We hypothesized that PINK1 protects the heart against acute ischemia reperfusion injury (IRI) by preventing mitochondrial dysfunction
MICU1 protects against myocardial ischemia/reperfusion injury and its control by the importer receptor Tom70
No full textPTEN-mediated mitophagy and APE1 overexpression protects against cardiac hypoxia/reoxygenation injury
No full textThe E3 ligase Mule protects the heart against oxidative stress and mitochondrial dysfunction through Myc-dependent inactivation of Pgc-1α and Pink1
No full textE2F1-dependent miR-421 regulates mitochondrial fragmentation and myocardial infarction by targeting Pink1
No full textGinsenoside Rd Attenuates Myocardial Ischemia/Reperfusion Injury via Akt/GSK-3β Signaling and Inhibition of the Mitochondria-Dependent Apoptotic Pathway
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