Programa transdiagnóstico de intervención en regulación emocional para pacientes con trastornos emocionales en atención primaria

73 p.En las últimas décadas, los estudios acerca de la regulación emocional se han incrementado debido a las novedosas investigaciones que han hallado su influencia en el desarrollo de trastornos emocionales en las sociedades del primer mundo. Al mismo tiempo, se ha empezado a incluir el concepto de intervención sobre los trastornos de una manera transdiagnóstica, es decir, analizando cuales son los procesos cognitivos, conductuales y emocionales comunes a este tipo de desórdenes emocionales. Basada en las revisiones actuales de tratamientos para la regulación emocional, nuestro principal objetivo es ofrecer un programa de intervención que unifique la terapia cognitivo-conductual con terapias de tercera generación, dirigida a pacientes con trastornos del estado del ánimo, trastornos ansiosos y adaptativos, y somatizaciones, en la edad adulta, que son atendidos en su centro de Atención Primaria. La intervención se plantea en formato grupal, tanto en vivo como de forma telemática. Diversas escalas y cuestionarios se usarán tanto para evaluar constructos como la atención emocional, aceptación, modulación y reconocimiento emocional, afecto, estrategias adaptativas y desadaptativas, factores de protección y resiliencia antes y después de la intervención para, así, poder evaluar la eficacia de la misma.In the last decade, the studies about emotional regulation have increased due to novel researches that have found its influence on the rapid develpment of emotional disorders in first world societies. At the same time, it started to include systematically the conception of the intervention of disordes in a transdiagnostic way, that is, to find the processes cognitive, behavioral and emotional strategies common to this type of emotional disorders. Based on a review of current treatments of emotional regulation, our main work is to offer an intervention program that unites Cognitive Behavioral Therapy (CBT) and third generation therapies, aimed at patients with mood disorders, anxious, adaptative disorders and somatized, of legal age, who attend their primary care center. It will be done under a group format, live and telematically. Several scales and questionnaires are used to have pre- and post- intervention measures to measure emotional attention, emotional acceptance and recognition, emotional labeling and modulation, adaptive and maladaptive strategies, protective factors and resilience.Máster Universitario en Psicología General Sanitaria (M169

Segmented software cost estimation models based on fuzzy clustering

Parametric software cost estimation models are based on mathematical relations, obtained from the study of historical software projects databases, that intend to be useful to estimate the effort and time required to develop a software product. Those databases often integrate data coming from projects of a heterogeneous nature. This entails that it is difficult to obtain a reasonably reliable single parametric model for the range of diverging project sizes and characteristics. A solution proposed elsewhere for that problem was the use of segmented models in which several models combined into a single one contribute to the estimates depending on the concrete characteristic of the inputs. However, a second problem arises with the use of segmented models, since the belonging of concrete projects to segments or clusters is subject to a degree of fuzziness, i.e. a given project can be considered to belong to several segments with different degrees. This paper reports the first exploration of a possible solution for both problems together, using a segmented model based on fuzzy clusters of the project space. The use of fuzzy clustering allows obtaining different mathematical models for each cluster and also allows the items of a project database to contribute to more than one cluster, while preserving constant time execution of the estimation process. The results of an evaluation of a concrete model using the ISBSG 8 project database are reported, yielding better figures of adjustment than its crisp counterpart.Ministerio de Ciencia y Tecnología TIN2004-06689-C0

Monitoring of the spatial and temporal variation of radon in an inhabited house, subjected to an underground source of radon from a well. Case study of Valsequillo in Gran Canaria..

Radon, a radioactive gas, is a recognized health hazard and a significant concern in residential environments. In this presentation, as part of a national radon project funded by the Nuclear Safety Council of Spain (CSN), a residential house in Valsequillo in Gran Canaria Island, Spain, was chosen for comprehensive radon monitoring. This study employed passive radon detectors as well as active radon detectors, to obtain long-term and real-time radon concentration data. Passive radon detectors were strategically placed in different rooms of the selected house and changed every three months to collect long-term radon concentration data. Active radon detectors were used to capture real-time measurements and provide a more detailed analysis of radon levels. Radon measurements were taken in the soil at a depth of one meter to evaluate radon emissions from the ground. Meteorological variables, including temperature, humidity, and atmospheric pressure, were recorded to characterize the local weather conditions. A comprehensive terrain characterization was performed, considering soil composition, permeability, and geological formations. The terrain characterization contributed to understanding the geological factors affecting radon levels in the area. The house was built on a characteristic terrain of superimposed lava flows, pyroclasts and mantles of volcanic breccias from the second eruptive cycle of the island of Gran Canaria (Roque Nublo Cycle), which form very thick packages (hundreds of meters). Regarding lithology, in the area there are basanitic-nephelitic, basaltic and olivinic-pyroxene lavas. The house is located on one of the slopes of the Barranco de San Miguel very close to the Protected Area of the Barranco de Los Cernícalos belonging to the Special Natural Reserve of Los Marteles. The area has a cold dry semi-arid climate, little influenced by the trade winds, with relatively little rainfall, more than 400 mm per year, and an average annual temperature of less than 20 degrees. The soil where the house is built is characterized by low radon levels, around 20 kBq/m3, and medium-high soil permeability. Despite what has been described, the house presents medium-high values of radon, in different rooms throughout the house and measured over time

Parameters monitorization in a Pilot House to provide data for indoor radon simulation and prediction purposes.

The Council Directive BSS 2013/59/Euratom establishes the Basic Safety Standards (BSS) that implies obligation to develop a regulatory framework to actively work to reduce radon exposure for workers and the public, and to reduce the reference level for the annual mean activity concentration in air to a maximum value of 300 Bq/m3 (REF). To fulfil the regulation guidelines, it is necessary to determine the critical parameters that affect to radon concentration indoor, which could allow carry out remedial actions. The study presented is performed within the framework of a national research project whose main objective is to study the validity of simulation tools for radon in air levels in closed rooms, which allow the analysis of different scenarios to develop action criteria. One of the experimental study cases for the set up and validation of developed models is the so-called Pilot House, located in the former uranium mine managed by the Spanish Uranium Company (ENUSA), based in Saelices el Chico (Salamanca, Spain). It is a module designed which pretends to reproduce the typological characteristics of a Spanish house (continental territory) using common materials for this construction type. In this presentation we will show the selection of parameters studied that could affect to indoor radon concentration in the Pilot House, the measurements methodology, the data collection system, and the time series obtained. It is therefore shown the time series of indoor radon concentration, radon concentration in soil, the meteorological parameters, And the differential air pressures measured at different points both inside and outside the pilot house, including those inside the soil around the building. Those time series will be the base for the radon simulation models available

Overview and new advances of RADSIM, a research project for the generation and validation of numerical models for the prediction of radon entry into buildings based on a characterization of the terrain and a typological definition of construction in Spain.

This presentation will address the progress of the RADSIM project whose purpose is to study the feasibility of numerical modelling to predict the entry of radon into buildings and its accumulation inside from a detailed characterization of the terrain and a typological definition of the building. The project is carried out in two locations, the Experimental Module of the Natural Radiation Laboratory (LNR) located at the ENUSA facilities in Saelices El Chico (Ciudad Rodrigo, Salamanca) and a dwelling on the island of Gran Canaria. Both sites are located in areas at risk of radon according to the mapping of the Nuclear Safety Council of Spain. The location of the sites makes it possible to cover different types of geology (continental and oceanic islands) and a greater variety of climatic zones. The two sites have been completely characterized in their radiologi

Comparison of a lumped-parameter and a distributed-parameter radon transport models adapted to an experimental radon accumulation chamber within the frame of the Spanish RADSIM project

Modelling indoor radon levels and their dynamics in the different rooms of a given dwelling is a very challenging task. Despite the different efforts carried out since the 90s to simulate indoor radon levels, there is still room for improvement in this field. This is mainly due not only to the complexity generated by the number of parameters and processes involved in the final balance of indoor radon levels and their dynamics, but also to the fact that the information required to apply the models in a specific inhabited site is hardly available. Indoor radon models might be classified into two categories: lumped-parameter models and distributed-parameter models. The first category includes the so-called compartmental models where an effective value is associated to each compartment of the model. These models use to solve a set of ordinary differential equations (ODE) in which the parameters of interest basically depend on time. On the contrary, in distributed-parameter models the parameters of interest normally depend on one or more space variables and can also depend on time as well. They solve a set of partial differential equations (PDE). An example of this type of models is those based on Computational Fluid Dynamics (CFD). The first category models are especially suitable to simulate the time-behavior of indoor radon levels in a multi-room dwelling, while the second type of models are more suitable to describe radon entry from soil into a dwelling through cracks by solving a radon transport equation. Within the frame of the Spanish RADSIM project, we will for the first time compare and validate two different models in two experimental sites. The compartmental RAGENA model developed at Universitat Autònoma de Barcelona (Font and Baixeras, 2003; Font et al. 2001) will be compared to the distributed-parameter CFD model developed at Instituto Eduardo Torroja (Muñoz et al. 2017). In this talk we will discuss the applicability of the different types of models in real cases and report on the results of the adaptation of the two models in a simple experimental case that constitutes our first intercomparison of the two models

On the use of numerical models to predict/mitigate indoor radon levels in highly contaminated areas

The publication of the EURATOM directive BSS 2013/59 [1] has increased considerably the interest on radon studies in all EU countries. Certainly each member state has to establish a national action plan addressing long-term risks from radon exposures in dwellings, buildings with public access and workplaces for any source of radon ingress, whether from soil, building materials or water. The complexity generated by the number of parameters and processes affecting radon generation in the source, transport in source media, entry into dwellings, and its accumulation in the different rooms of the dwelling, makes the development of numerical models a very challenging exercise that might take also into account that the detailed information of the building-soil interface in an existing dwelling is normally not available. A new project funded by the Spanish Nuclear Safety Board (CSN) started in 2020. Its main goal is to establish and validate a numerical tool to predict and mitigate indoor radon levels in new and existing buildings in general, but paying special attention to the case of areas contaminated due to NORM industrial activities. Such a numerical tool might be of interest for Radiation Protection authorities to manage highly contaminated areas. In particular, 2 different numerical modelling strategies will be adapted to real sites and compared. The RAGENA [2] code, which was developed in the late 90s, will be updated with the last findings from experimental studies. This code allows modelling all radon sources and processes affecting radon accumulation indoors from a dynamic point of view in a very simple way, but lacks from spatial resolution. On the other hand, a CFD (computational fluid dynamics) model recently developed in Spain [3] numerically solves radon transport equation by finite elements with a good spatial resolution. The project focuses also on the experimental characterization of real sites. In this talk we will introduce the project, discuss the main features of both modelling approaches and describe in more detail the current status of the RAGENA code updating

In Vitro Antifungal Activity of Ibrexafungerp (SCY-078) Against Contemporary Blood Isolates From Medically Relevant Species of Candida: A European Study

BackgroundIbrexafungerp (SCY-078) is the newest oral and intravenous antifungal drug with broad activity, currently undergoing clinical trials for invasive candidiasis. ObjectiveThe aim of this study was to assess the in vitro activity of ibrexafungerp and comparators against a collection of 434 European blood isolates of Candida. MethodsIbrexafungerp, caspofungin, fluconazole, and micafungin minimum inhibitory concentrations (MICs) were collected from 12 European laboratories for 434 blood isolates, including 163 Candida albicans, 108 Candida parapsilosis, 60 Candida glabrata, 40 Candida tropicalis, 29 Candida krusei, 20 Candida orthopsilosis, 6 Candida guilliermondii, 2 Candida famata, 2 Candida lusitaniae, and 1 isolate each of Candida bracarensis, Candida catenulata, Candida dubliniensis, and Candida kefyr. MICs were determined by the EUCAST broth microdilution method, and isolates were classified according to recommended clinical breakpoints and epidemiological cutoffs. Additionally, 22 Candida auris from different clinical specimens were evaluated. ResultsIbrexafungerp MICs ranged from 0.016 to >= 8 mg/L. The lowest ibrexafungerp MICs were observed for C. albicans (geometric MIC 0.062 mg/L, MIC range 0.016-0.5 mg/L) and the highest ibrexafungerp MICs were observed for C. tropicalis (geometric MIC 0.517 mg/L, MIC range 0.06->= 8 mg/L). Modal MICs/MIC(50)s (mg/L) against Candida spp. were 0.125/0.06 for C. albicans, 0.5/0.5 for C. parapsilosis, 0.25/0.25 for C. glabrata, 0.5/0.5 for C. tropicalis, 1/1 for C. krusei, 4/2 for C. orthopsilosis, and 0.5/0.5 for C. auris. Ibrexafungerp showed activity against fluconazole- and echinocandin-resistant isolates. If adopting wild-type upper limits, a non-wild-type phenotype for ibrexafungerp was only observed for 16/434 (3.7%) isolates: 11 (4.6%) C. parapsilosis, 4 (5%) C. glabrata, and 1 (2.5%) C. tropicalis. ConclusionIbrexafungerp showed a potent in vitro activity against Candida.This study received funding from SCYNEXIS. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of the article, or the decision to submit it for publication. CM-A is a recipient of a grant from Fundació n ONCE (Oportunidad al Talento). EE, AG, NJ, CM-A, and GQ have received grant support from Consejerı́a de Educación, Universidades e Investigación del Gobierno Vasco (GIC15 IT-990-16), Fondo de Investigación Sanitaria del Gobierno de España (FIS PI11/00203), and UPV/EHU (UFI 11/25). All authors declare no other competing interests

Task force IRSPM A&A SIG, CIGAR Network, EGPA PSG XII

The IPSAS CP asks the following questions in its REQUEST FOR COMMENTS. The responses prepared by the Task Force IRSPM A&A SIG, CIGAR Network and EGPA PSG XII are presented hereafter. The IRSPM A&A SIG, CIGAR Network and EGPA PSG XII are three research networks that focus on Public Sector Accounting. The Task Force is made up of 16 researchers from these networks. The responses being presented are based on an analysis of the Consultation Paper, the IPSASB Conceptual Framework, relevant IPSAS, and various published research papers on the subject. Following various meetings and discussions, the members of the Task Force have reached the following common conclusions and suggestions. The views expressed in this document represent those of the members of the Task Force and not of the whole research community represented by the networks, and neither of the Institutions/Universities with which they are affiliated

Performance of Screening Strategies for Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease: Results from the ENEIDA Registry of GETECCU

(1) Aims: Patients receiving antitumor necrosis factor (anti-TNF) therapy are at risk of developing tuberculosis (TB), usually due to the reactivation of a latent TB infection (LTBI). LTBI screening and treatment decreases the risk of TB. This study evaluated the diagnostic performance of different LTBI screening strategies in patients with inflammatory bowel disease (IBD). (2) Methods: Patients in the Spanish ENEIDA registry with IBD screened for LTBI between January 2003 and January 2018 were included. The diagnostic yield of different strategies (dual screening with tuberculin skin test [TST] and interferon-gamma-release assay [IGRA], two-step TST, and early screening performed at least 12 months before starting biological treatment) was analyzed. (3) Results: Out of 7594 screened patients, 1445 (19%; 95% CI 18-20%) had LTBI. Immunomodulator (IMM) treatment at screening decreased the probability of detecting LTBI (20% vs. 17%, p = 0.001). Regarding screening strategies, LTBI was more frequently diagnosed by dual screening than by a single screening strategy (IGRA, OR 0.60; 95% CI 0.50-0.73, p < 0.001; TST, OR 0.76; 95% CI 0.66-0.88, p < 0.001). Two-step TST increased the diagnostic yield of a single TST by 24%. More cases of LTBI were diagnosed by early screening than by routine screening before starting anti-TNF agents (21% [95% CI 20-22%] vs. 14% [95% CI 13-16%], p < 0.001). The highest diagnostic performance for LTBI (29%) was obtained by combining early and TST/IGRA dual screening strategies in patients without IMM. (4): Conclusions: Both early screening and TST/IGRA dual screening strategies significantly increased diagnostic performance for LTBI in patients with IBD, with optimal performance achieved when they are used together in the absence of IMM