[(3aS,5aR,8aR,8bS)-2,2,7,7-Tetra­methyl­tetra­hydro-3aH-bis­[1,3]dioxolo[4,5-b:4′,5′-d]pyran-3a-yl]methyl (R)-N-(1-phenyl­eth­yl)sulfamate

In the title compound, C20H29NO8S, the two five-membered rings adopt envelope conformations (with an O atom at the flap in each case), while the six-membered pyran ring displays a twist-boat conformation. In the crystal, mol­ecules are linked by N—H⋯O hydrogen bonds into a supra­molecular chain running along the a axis

Research progress on the application of organoids in gynecological tumors

Organoids are in vitro 3D models that maintain their own tissue structure and function. They largely overcome the limitations of traditional tumor models and have become a powerful research tool in the field of oncology in recent years. Gynecological malignancies are major diseases that seriously threaten the life and health of women and urgently require the establishment of models with a high degree of similarity to human tumors for clinical studies to formulate individualized treatments. Currently, organoids are widely studied in exploring the mechanisms of gynecological tumor development as a means of drug screening and individualized medicine. Ovarian, endometrial, and cervical cancers as common gynecological malignancies have high morbidity and mortality rates among other gynecological tumors. Therefore, this study reviews the application of modelling, drug efficacy assessment, and drug response prediction for ovarian, endometrial, and cervical cancers, thereby clarifying the mechanisms of tumorigenesis and development, and providing precise treatment options for gynecological oncology patients

A Security and Efficient Routing Scheme with Misbehavior Detection in Delay-Tolerant Networks

Due to the unique network characteristics, the security and efficient routing in DTNs are considered as two great challenges. In this paper, we design a security and efficient routing scheme, called SER, which integrates the routing decision and the attacks detection mechanisms. In SER scheme, each DTNs node locally maintains a one-dimensional vector table to record the summary information about the contact with other nodes and the trust degree of other nodes. To obtain the global status and the contact relationship among all nodes, the trusted routing table consisting of vectors of all nodes is built in each DTNs node. The method for detecting malicious nodes and selfish nodes is proposed, which exploits the global summary information to analyze the history forwarding behavior of node and judge whether it is a malicious node or selfish node. The routing decision method is proposed based on trust degree of forwarding messages between nodes, which adopts trust degree as relay node selection strategy. Simulation results show that compared with existing schemes SER scheme could detect the attacks behavior of malicious nodes and selfish nodes, at the same time, with higher delivery rate and lower average delivery delay

The `excess' of primary cosmic ray electrons

With the accurate cosmic ray (CR) electron and positron spectra (denoted as $\Phi_{\rm e^{-}}$ and $\Phi_{\rm e^{+}}$, respectively) measured by AMS-02 collaboration, the difference between the electron and positron fluxes (i.e., $\Delta \Phi=\Phi_{\rm e^{-}}-\Phi_{\rm e^{+}}$), dominated by the propagated primary electrons, can be reliably inferred. In the standard model, the spectrum of propagated primary CR electrons at energies $\geq 30$ GeV softens with the increase of energy. The absence of any evidence for such a continuous spectral softening in $\Delta \Phi$ strongly suggests a significant `excess' of primary CR electrons and at energies of $100-400$ GeV the identified excess component has a flux comparable to that of the observed positron excess. Middle-age but `nearby' supernova remnants (e.g., Monogem and Geminga) are favored sources for such an excess.Comment: 13 pages, 2 figures, Phys. Lett. B, in pres

A Hierarchical Dataflow-Driven Heterogeneous Architecture for Wireless Baseband Processing

Wireless baseband processing (WBP) is a key element of wireless communications, with a series of signal processing modules to improve data throughput and counter channel fading. Conventional hardware solutions, such as digital signal processors (DSPs) and more recently, graphic processing units (GPUs), provide various degrees of parallelism, yet they both fail to take into account the cyclical and consecutive character of WBP. Furthermore, the large amount of data in WBPs cannot be processed quickly in symmetric multiprocessors (SMPs) due to the unpredictability of memory latency. To address this issue, we propose a hierarchical dataflow-driven architecture to accelerate WBP. A pack-and-ship approach is presented under a non-uniform memory access (NUMA) architecture to allow the subordinate tiles to operate in a bundled access and execute manner. We also propose a multi-level dataflow model and the related scheduling scheme to manage and allocate the heterogeneous hardware resources. Experiment results demonstrate that our prototype achieves $2\times$ and $2.3\times$ speedup in terms of normalized throughput and single-tile clock cycles compared with GPU and DSP counterparts in several critical WBP benchmarks. Additionally, a link-level throughput of $288$ Mbps can be achieved with a $45$-core configuration.Comment: 7 pages, 7 figures, conferenc

Tag SNP Polymorphism of CCL2 and Its Role in Clinical Tuberculosis in Han Chinese Pediatric Population

BACKGROUND: Chemokine (C-C motif) ligand 2 CCL2/MCP-1 is among the key signaling molecules of innate immunity; in particular, it is involved in recruitment of mononuclear and other cells in response to infection, including tuberculosis (TB) and is essential for granuloma formation. METHODOLOGY/PRINCIPAL FINDINGS: We identified a tag SNP for the CCL2/MCP-1 gene (rs4586 C/T). In order to understand whether this SNP may serve to evaluate the contribution of the CCL2 gene to the expression of TB disease, we further analysed distribution of its alleles and genotypes in 301 TB cases versus 338 non-infected controls (all BCG vaccinated) representing a high-risk pediatric population of North China. In the male TB subgroup, the C allele was identified in a higher rate (P = 0.045), and, acting dominantly, was found to be a risk factor for clinical TB (P = 0.029). Homozygous TT genotype was significantly associated with lower CSF mononuclear leukocyte (ML) counts in patients with tuberculous meningitis (TBM) (P = 0.001). CONCLUSIONS/SIGNIFICANCE: The present study found an association of the CCL2 tag SNP rs4586 C allele and pediatric TB disease in males, suggesting that gender may affect the susceptibility to TB even in children. The association of homozygous TT genotype with decreased CSF mononuclear leukocyte (ML) count not only suggests a clinical significance of this SNP, but indicates its potential to assist in the clinical assessment of suspected TBM, where delay is critical and diagnosis is difficult