2,379 research outputs found
The Regenerating Gene Iα Is Overexpressed in Atrophic Gastritis Rats with Hypergastrinemia
The role of gastrin on the development of atrophic gastritis (AG) and its relationship with the expression of RegIα in vivo remain unclear. We established experimental AG in rats by combination administration with sodium salicylate, alcohol, and deoxycholate sodium. The mean score of inflammation in gastric antrum in AG rats was significantly elevated (P < 0.05), while the number of glands dramatically decreased (P < 0.05). In addition, the cell proliferation in gastric glands was increased in experimental AG rats, as determined by immunohistochemistry staining of PCNA and GS II. The level of serum gastrin in AG rats was significantly elevated relative to that of normal rats (P < 0.01). Moreover, the expression of RegIα protein and its receptor mRNA was increased in gastric tissues in AG rats (P < 0.05). Taken together, we demonstrated that the overexpression of Reglα is related with hypergastrinemia in AG rats
The linear and nonlinear Jaynes-Cummings model for the multiphoton transition
With the Jaynes-Cummings model, we have studied the atom and light field
quantum entanglement of multiphoton transition, and researched the effect of
initial state superposition coefficient , the transition photon number
, the quantum discord and the nonlinear coefficient on the
quantum entanglement degrees. We have given the quantum entanglement degrees
curves with time evolution, and obtained some results, which should have been
used in quantum computing and quantum information.Comment: arXiv admin note: text overlap with arXiv:1404.0821, arXiv:1205.0979
by other author
Complete genome sequencing and analysis of six enterovirus 71 strains with different clinical phenotypes
BACKGROUND: Hand, foot and mouth diseases (HFMD) caused by enterovirus 71(EV71) presents a broad spectrum of clinical manifestations ranging from mild febrile disease to fatal neurolocal disease. However, the mechanism of virulence is unknown. METHODS: We isolated 6 strains of EV71 from HFMD patients with or without neurological symptoms, and sequenced the whole genomes of the viruses to reveal the virulence factors of EV71. RESULTS: Phylogenetic tree based on VP1 region showed that all six strains clustered into C4a of C4 sub-genotype. In the complete polypeptide, 298 positions were found to be variable in all strains, and three of these positions (Val(P814)/Ile(P814) in VP1, Val(P1148)/Ile(P1148) in 3A and Ala (P1728)/Cys (P1728)/Val (P1728) in 3C) were conserved among the strains with neurovirulence, but variable in strains without neurovirulence. In the 5(′)-UTR region, it showed that the first 10 nucleotides were mostly conserved, however from the 11th nucleotide, nucleotide insertions and deletions were quite common. The secondary structure prediction of 5(′)-UTR sequences showed that two of three strains without neurovirulence (SDLY11 and SDLY48) were almost the same, and all strains with neurovirulence (SDLY96, SDLY107 and SDLY153) were different from each other. SDLY107 (a fatal strain) was found different from other strains on four positions (C(P241)/T(P241), A(P571)/T(P571), C(P579)/T(P579) in 5(′)-UTR and T(P7335)/C(P7335) in 3(′)-UTR). CONCLUSIONS: The three positions (Val(P814)/Ile(P814) in VP1, Val(P1148)/Ile(P1148) in 3A and Ala (P1728)/Cys (P1728)/Val (P1728) in 3C), were different between two phenotypes. These suggested that the three positions might be potential virulent positions. And the three varied positions were also found to be conserved in strains with neurovirulence, and variable in strains without neurovirulence. These might reveal that the conservation of two of the three positions or the three together were specific for the strains with neurovirulence. Varation of secondary structure of 5(′)-UTR, might be correlated to the changes of viral virulence. SDLY107 (a fatal strain) was found different from other strains on four positions, these positions might be related with death
Measurement-device-independent quantum key distribution over untrustful metropolitan network
Quantum cryptography holds the promise to establish an
information-theoretically secure global network. All field tests of
metropolitan-scale quantum networks to date are based on trusted relays. The
security critically relies on the accountability of the trusted relays, which
will break down if the relay is dishonest or compromised. Here, we construct a
measurement-device-independent quantum key distribution (MDIQKD) network in a
star topology over a 200 square kilometers metropolitan area, which is secure
against untrustful relays and against all detection attacks. In the field test,
our system continuously runs through one week with a secure key rate ten times
larger than previous result. Our results demonstrate that the MDIQKD network,
combining the best of both worlds --- security and practicality, constitutes an
appealing solution to secure metropolitan communications.Comment: 17 pages, 4 figure
- …