Long Non-Coding RNAs in Cardiac Remodeling

Cardiac remodeling occurs after stress to the heart, manifested as pathological processes, including hypertrophy and apoptosis of cardiomyocytes, dysfunction of vascular endothelial cells and vascular smooth muscle cells as well as differentiation and proliferation of fibroblasts, ultimately resulting in progression of cardiovascular diseases. Emerging evidence has revealed that long non-coding RNAs (lncRNAs) acted as powerful and dynamic modifiers of cardiac remodeling. LncRNAs including Chaer, Chast, Mhrt, CHRF, ROR, H19, and MIAT have been implicated in cardiac hypertrophy while NRF, H19, APF, CARL, UCA, Mhrt and several other lncRNAs (n379599, n379519, n384640, n380433 and n410105) in cardiomyocyte loss and extracellular matrix remodeling. In addition, MALAT1 and TGFB2-OT1 have been reported to contribute to vascular endothelial cells dysfunction while lincRNA-p21 and lnc-Ang362 to vascular smooth muscle cells proliferation. Thus, manipulation of lncRNA expression levels through either the inhibition of disease-up-regulated lncRNAs or increasing disease-down-regulated lncRNAs represents novel therapeutic strategies for cardiac remodeling

Narrow-Linewidth Tunable Fiber Laser Based on Laser-Induced Graphene Heated Fiber Bragg Grating with Low Voltage

In this paper, we demonstrate a narrow-linewidth tunable fiber laser based on laser-induced graphene (LIG) paper-heated fiber Bragg grating (FBG) with low voltage. A linewidth of less than 600 Hz is achieved by the combination of a piece of unpumped Er-doped fiber and an FBG. Changing the temperature of the FBG will result in the central transmission spectrum shifting, and hence the laser wavelength tuning. LIG-heated (LIG-H) fabrication on polyimide (PI) paper by CO2 laser is used to offer temperature control of the FBG. By adjusting the voltage of the LIG-H from 0 to 5 V, the temperature of the LIG-H can be changed from room temperature up to 220 °C, while the central wavelength of the output laser can be continuously adjusted from 1549.5 nm to 1552 nm with a full range of 2.5 nm. The proposed technique by electric control of LIG-H can provide a low-cost and compact wavelength tunable laser design

PI3K/Akt-independent negative regulation of JNK signaling by MKP-7 after cerebral ischemia in rat hippocampus

Abstract Background The inactivation of c-Jun N-terminal kinase (JNK) is associated with anti-apoptotic and anti-inflammatory effects in cerebral ischemia, which can be induced by an imbalance between upstream phosphatases and kinases. Result Mitogen-activated protein kinase phosphatase 7 (MKP-7) was upregulated significantly at 4 h of reperfusion postischemia in rat hippocampi. By administration of cycloheximide or siRNA against mitogen-activated protein kinase phosphatase 7 (MKP-7) in a rat model of ischemia/reperfusion, an obvious enhancement of JNK activity was observed in 4 h of reperfusion following ischemia, suggesting MKP-7 was involved in JNK inactivation after ischemia. The subcellular localization of MKP-7 altered after ischemia, and the inhibition of MKP-7 nuclear export by Leptomycin B up-regulated JNK activity. Although PI3K/Akt inhibition could block downregulation of JNK activity through SEK1 and MKK-7 activation, PI3K/Akt activity was not associated with the regulation of JNK by MKP-7. Conclusions MKP-7, independently of PI3K/Akt pathway, played a key role in downregulation of JNK activity after ischemia in the rat hippocampus, and the export of MKP-7 from the nucleus was involved in downregulation of cytoplasmic JNK activity in response to ischemic stimuli.</p

Narrow-Linewidth Tunable Fiber Laser Based on Laser-Induced Graphene Heated Fiber Bragg Grating with Low Voltage

In this paper, we demonstrate a narrow-linewidth tunable fiber laser based on laser-induced graphene (LIG) paper-heated fiber Bragg grating (FBG) with low voltage. A linewidth of less than 600 Hz is achieved by the combination of a piece of unpumped Er-doped fiber and an FBG. Changing the temperature of the FBG will result in the central transmission spectrum shifting, and hence the laser wavelength tuning. LIG-heated (LIG-H) fabrication on polyimide (PI) paper by CO2 laser is used to offer temperature control of the FBG. By adjusting the voltage of the LIG-H from 0 to 5 V, the temperature of the LIG-H can be changed from room temperature up to 220 &deg;C, while the central wavelength of the output laser can be continuously adjusted from 1549.5 nm to 1552 nm with a full range of 2.5 nm. The proposed technique by electric control of LIG-H can provide a low-cost and compact wavelength tunable laser design