Optimized electroacupuncture treatment for female stress urinary incontinence: study protocol for a multi-center randomized controlled trial

BackgroundStress urinary incontinence (SUI) is a common condition that can severely affect women’s life quality. Electroacupuncture (EA) has been proved to be an optional treatment for SUI, but the tolerance of EA becomes a factor affecting efficiency, which should not be ignored and needs to be solved urgently. The purpose of this study is to find out whether the use of alternating acupoints combination can solve this problem or not and provide an optimization of EA treatment for female SUI.MethodsThis multi-center randomized controlled trial will enroll 360 patients with SUI. They will be randomly assigned to one of the three groups—sacral acupoints group (sacral group), abdominal acupoints group (abdominal group), or alternating acupoints group (alternating group)—at a 1:1:1 ratio. The patients will receive 18 sessions of EA treatment and will be followed up for 48 weeks after the treatment. The primary outcome measure of the study is the change of urine leakage at week 6. The secondary outcomes include the incontinence episode frequency (IEF), International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF), severity of SUI, patient self-evaluation of therapeutic effects, weekly usage of urine pads, ultrasonography of pelvic floor, specialty therapies for SUI, evaluation of discomfort during EA treatment, patient acceptability evaluation and adverse events related to intervention.DiscussionThis trial is specifically designed to offer an optimized EA treatment for female SUI, aiming to enhance their quality of life.Clinical trial registration: ClinicalTrials.gov, identifier ID:NCT05635669

Therapeutic effects of coronary granulocyte colony-stimulating factor on rats with chronic ischemic heart disease

The aim of this study was to evaluate the therapeutic effects of coronary granulocyte colony-stimulating factor (G-CSF) on rats with chronic ischemic heart disease (CIHD)

Key grouting technology and engineering demonstration for green mines

This study proposed the multi-coupling grouting system with the aim to tackle green mine problems such as surface collapse, water resources destruction and coal based solid waste accumulation.Successfully applied, this system yielded the following major achievements: this study (1) probed into the patterns of development and evolution in mining separation space and primary fracture space, and conducted the intelligent identification of grouting space by means of theoretical analysis, physical and numerical simulation and field detection.(2) prepared multi-source inorganic high-performance grouting materials for different scenarios by using coal-based solid wastes (coal gangue, fly ash), and developed a new KEP grouting material with underwater dispersion resistance, high volume coefficient and high plastic strength.(3) applied cluster well and feather well to grouting hole drilling and and developed an all-weather, high pump pressure and large flow intelligent grouting system; The reinforcement grouting technology is applied for the first time to strengthen the effect of grouting to reduce settlement.(4)put forward the technology system of grouting effect monitoring and detection, and emphatically expounded the borehole detection method of combining drilling core and well logging.(5)formed an intelligent technology system based on the methods of separation space grouting to reduce settlement and treat waste, caving zone grouting to treat waste, goaf grouting to strengthen foundation bearing capacity and treat waste, and roof fissure grouting to control water gushing as the core.Engineering demonstrations of this system have been carried out in Xiadian coal mine, Xinpu phosphate mine, Caojiatan coal mine, Gaojiabao coal mine and other places, which yielded good results

A test of enhancing model accuracy in high-throughput crystallography

Abstract The high throughput of structure determination pipelines relies on increased automation and, consequently, a reduction of time spent on interactive quality control. In order to meet and exceed current standards in model accuracy, new approaches are needed for the facile identification and correction of model errors during refinement. One such approach is provided by the validation and structureimprovement tools of the MOLPROBITY web service. To test their effectiveness in high-throughput mode, a large subset of the crystal structures from the SouthEast Collaboratory for Structural Genomics (SECSG) has used protocols based on the MOLPROBITY tools. Comparison of 29 working-set and 19 control-set SECSG structures shows that working-set outlier scores for updated Ramachandran-plot, sidechain rotamer, and all-atom steric criteria have been improved by factors of 5-to 10-fold (relative to the control set or to a Protein Data Bank sample), while quality of covalent geometry, R work , R free , electron density and difference density are maintained or improved. Some parts of this correction process are already fully automated; other parts involve manual rebuilding of conformations flagged by the tests as trapped in the wrong local minimum, often altering features of functional significance. The ease and effectiveness of this technique shows that macromolecular crystal structures from either traditional or high-throughput determinations can feasibly reach a new level of excellence in conformational accuracy and reliability