Thickness Insensitive Nanocavities for 2D Heterostructures using Photonic Molecules

Two-dimensional (2D) heterostructures integrated into nanophotonic cavities have emerged as a promising approach towards novel photonic and opto-electronic devices. However, the thickness of the 2D heterostructure has a strong influence on the resonance frequency of the nanocavity. For a single cavity, the resonance frequency shifts approximately linearly with the thickness. Here, we propose to use the inherent non-linearity of the mode coupling to render the cavity mode insensitive to the thickness of the 2D heterostructure. Based on the couple mode theory, we reveal that this goal can be achieved using either a homoatomic molecule with a filtered coupling or heteroatomic molecules. We perform numerical simulations to further demonstrate the robustness of the eigenfrequency in the proposed photonic molecules. Our results render nanophotonic structures insensitive to the thickness of 2D materials, thus owing appealing potential in energy- or detuning-sensitive applications such as cavity quantum electrodynamics

Document-Level Machine Translation with Large Language Models

Large language models (LLMs) such as Chat-GPT can produce coherent, cohesive, relevant, and fluent answers for various natural language processing (NLP) tasks. Taking document-level machine translation (MT) as a testbed, this paper provides an in-depth evaluation of LLMs' ability on discourse modeling. The study fo-cuses on three aspects: 1) Effects of Discourse-Aware Prompts, where we investigate the impact of different prompts on document-level translation quality and discourse phenomena; 2) Comparison of Translation Models, where we compare the translation performance of Chat-GPT with commercial MT systems and advanced document-level MT methods; 3) Analysis of Discourse Modelling Abilities, where we further probe discourse knowledge encoded in LLMs and examine the impact of training techniques on discourse modeling. By evaluating a number of benchmarks, we surprisingly find that 1) leveraging their powerful long-text mod-eling capabilities, ChatGPT outperforms commercial MT systems in terms of human evaluation. 2) GPT-4 demonstrates a strong ability to explain discourse knowledge, even through it may select incorrect translation candidates in contrastive testing. 3) ChatGPT and GPT-4 have demonstrated superior performance and show potential to become a new and promising paradigm for document-level translation. This work highlights the challenges and opportunities of discourse modeling for LLMs, which we hope can inspire the future design and evaluation of LLMs

Immunophenotyping in BK Virus Allograft Nephropathy Distinct from Acute Rejection

Differentiating BK virus nephropathy (BKVN) from acute rejection (AR) is crucial in clinical practice, as both of them have interstitial inflammation in the grafts. The purpose of the study is to describe the inflammatory cellular constituents of BKVN and to determine the clinical utility of immunophenotyping findings in distinguishing BKVN from AR. In addition, the expression of the HLA-DR was investigated. Sixty-five renal allograft recipients were included in this study, including 22 cases of BKVN, 31 cases of AR, and 12 cases of stable allograft. Immunostaining for infiltrating lymphocytes showed that the number of CD20 cells (P<0.001) and the percentages of CD3 (P<0.001), CD4 (P=0.004), CD8 (P=0.005), and CD20 (P=0.002) cells were all significantly different between BKVN and AR. Moreover, there were no statistically significant differences in tubule cell HLA-DR expression (P=0.156). This observation suggests that the number of CD20 cells and the percentages of CD3, CD4, CD8, and CD20 cells in renal biopsies would aid the distinction between BKVN and AR. On the other hand, the presence of HLA-DR upregulation may not only be specific for acute rejection but also be a response to BKVN

Risk assessment model for sleep disturbance based on gastrointestinal myoelectrical activity in middle-aged and elderly people

BackgroundSleep disturbance has become a considerable factor affecting the quality of life for middle-aged and elderly people; however, there are still many obstacles to screening sleep disturbance for those people. Given the growing awareness of the association between gastrointestinal function and sleep disturbance, our study aims to predict the risk of sleep disturbance using gastrointestinal electrophysiological signals.MethodsThe Pittsburgh Sleep Quality Index and gastrointestinal electrophysiological signals of 914 participants in western China were used to establish the model. Demographic characteristics and routine blood test were collected as covariates. Participants were randomly assigned into two sets with a 7:3 ratio for training and validation. In the training set, the least absolute shrinkage and selection operator (LASSO) regression and stepwise logistic regression were used, respectively for variables selection and optimization. To assess the model performance, receiver operator characteristic (ROC) curve, calibration curve and decision curve analysis (DCA) were utilized. Then, validation was performed.ResultsThirteen predictors were chosen from 46 variables by LASSO regression. Then, age, gender, percentage of normal slow wave and electrical spreading rate on the pre-meal gastric channel, dominant power ratio on the post-meal gastric channel, coupling percent and dominant frequency on the post-meal intestinal channel were the seven predictors reserved by logistic regression. The area under ROC curve was 0.65 in the training set and 0.63 in the validation set, both exhibited moderate predictive ability. Furthermore, by overlapping the DCA results of two data-sets, there might be clinical net benefit if 0.35 was used as reference threshold for high risk of sleep disturbance.ConclusionThe model performs a worthy predictive potency for sleep disturbance, which not only provides clinical evidence for the association of gastrointestinal function with sleep disturbance, but also can be considered as an auxiliary assessment for screening sleep disturbance

Production Across the Nordics

In the uncertain and volatile market that companies are currently facing worldwide, researchers and engineers\ua0become a key link to\ua0strengthen the industry and universities\ua0in order to\ua0understand, communicate, and tackle\ua0current challenges. In the PhD course, International Production, the goal is to investigate what makes Sweden and Iceland booming industrial hubs\ua0driven by technology. Through the\ua0visits to different types of industries, such as fintech, medical, or automotive industry,\ua0we as researchers have gained a better understanding of the challenges they are currently facing. This report is a summary of our findings and observations.\ua0\ua0The participants have focused on the\ua0six challenge areas highlighted within the Produktion2030 graduate school and summarize their findings as:\ua0\ua0•Resource-efficient production:\ua0Data as a resource is becoming increasingly important for the majority of companies in the Nordics and the application of traditional resource management tools on data is a suggested area for future research. \ua0•Flexible production:To strengthen organizations by\ua0enabling\ua0production systems to be flexible to address\ua0market variations is a key\ua0challenge to consider in the manufacturing industry•Virtual production development:Digitalization level is distinct in each Nodic country with the reason that each country has its own digitalization transformation policy and different measures on digitalization level.\ua0•Humans in the production system:Humans are central in the production systems of the visited companies. Use of automation technology and AI to support humans in their work may become more common in the future.•Circular production systems and maintenance:Circular production systems require a complex approach through the whole value chain. Industry in the Nordics has started the adoption of a circularity approach.\ua0•Integrated product and production development:\ua0Integration of product and production development is a key business factor for the Nordic countries, and geographical proximity between the two departments can have a beneficial effect. \ua0We hope that this report provides more\ua0details\ua0regarding\ua0the success and current challenges of the Swedish and Icelandic enterprises

Connection between right-to-left shunt and photosensitivity: a community-based cross-sectional study

BackgroundHypersensitivity to light is a common symptom associated with dysfunction of the occipital region. Earlier studies also suggested that clinically significant right-to-left shunt (RLS) could increase occipital cortical excitability associated with the occurrence of migraine. The aim of this study was to investigate the relationship between RLS and photosensitivity.MethodsThis cross-sectional observational study included the residents aged 18–55 years living in the Mianzhu community between November 2021 and October 2022. Photosensitivity was evaluated using the Photosensitivity Assessment Questionnaire along with baseline clinical data through face-to-face interviews. After the interviews, contrast-transthoracic echocardiography (cTTE) was performed to detect RLS. Inverse probability weighting (IPW) was used to reduce selection bias. Photosensitivity score was compared between individuals with and without significant RLS using multivariable linear regression based on IPW.ResultsA total of 829 participants containing 759 healthy controls and 70 migraineurs were finally included in the analysis. Multivariable linear regression analysis showed that migraine (β = 0.422; 95% CI: 0.086–0.759; p = 0.014) and clinically significant RLS (β = 1.115; 95% CI: 0.760–1.470; p &lt; 0.001) were related to higher photosensitivity score. Subgroup analysis revealed that clinically significant RLS had a positive effect on hypersensitivity to light in the healthy population (β = 0.763; 95% CI: 0.332–1.195; p &lt; 0.001) or migraineurs (β = 1.459; 95% CI: 0.271–2.647; p = 0.010). There was also a significant interaction between RLS and migraine for the association with photophobia (pinteraction = 0.009).ConclusionRLS is associated with photosensitivity independently and might exacerbate photophobia in migraineurs. Future studies with RLS closure are needed to validate the findings.Trial registrationThis study was registered at the Chinese Clinical Trial Register, Natural Population Cohort Study of West China Hospital of Sichuan University, ID: ChiCTR1900024623, URL: https://www.chictr.org.cn/showproj.html?proj=40590

The Prevalence of Immunologic Injury in Renal Allograft Recipients with De Novo Proteinuria

Post-transplant proteinuria is a common complication after renal transplantation; it is associated with reduced graft and recipient survival. However, the prevalence of histological causes has been reported with considerable variation. A clinico-pathological re-evaluation of post-transplant proteinuria is necessary, especially after dismissal of the term “chronic allograft nephropathy,” which had been considered to be an important cause of proteinuria. Moreover, urinary protein can promote interstitial inflammation in native kidney, whether this occurs in renal allograft remains unknown. Factors that affect the graft outcome in patients with proteinuria also remain unclear. Here we collected 98 cases of renal allograft recipients who developed proteinuria after transplant, histological features were characterized using Banff scoring system. Cox proportional hazard regression models were used for graft survival predictors. We found that transplant glomerulopathy was the leading (40.8%) cause of post-transplant proteinuria. Immunological causes, including transplant glomerulopathy, acute rejection, and chronic rejection accounted for the majority of all pathological causes of proteinuria. Nevertheless, almost all patients that developed proteinuria had immunological lesions in the graft, especially for interstitial inflammation. Intraglomerular C3 deposition was unexpectedly correlated with the severity of proteinuria. Moreover, the severity of interstitial inflammation was an independent risk factor for graft loss, while high level of hemoglobin was a protective factor for graft survival. This study revealed a predominance of immunological parameters in renal allografts with post-transplant proteinuria. These parameters not only correlate with the severity of proteinuria, but also with the outcome of the graft

The Genomes of Oryza sativa: A History of Duplications

We report improved whole-genome shotgun sequences for the genomes of indica and japonica rice, both with multimegabase contiguity, or almost 1,000-fold improvement over the drafts of 2002. Tested against a nonredundant collection of 19,079 full-length cDNAs, 97.7% of the genes are aligned, without fragmentation, to the mapped super-scaffolds of one or the other genome. We introduce a gene identification procedure for plants that does not rely on similarity to known genes to remove erroneous predictions resulting from transposable elements. Using the available EST data to adjust for residual errors in the predictions, the estimated gene count is at least 38,000–40,000. Only 2%–3% of the genes are unique to any one subspecies, comparable to the amount of sequence that might still be missing. Despite this lack of variation in gene content, there is enormous variation in the intergenic regions. At least a quarter of the two sequences could not be aligned, and where they could be aligned, single nucleotide polymorphism (SNP) rates varied from as little as 3.0 SNP/kb in the coding regions to 27.6 SNP/kb in the transposable elements. A more inclusive new approach for analyzing duplication history is introduced here. It reveals an ancient whole-genome duplication, a recent segmental duplication on Chromosomes 11 and 12, and massive ongoing individual gene duplications. We find 18 distinct pairs of duplicated segments that cover 65.7% of the genome; 17 of these pairs date back to a common time before the divergence of the grasses. More important, ongoing individual gene duplications provide a never-ending source of raw material for gene genesis and are major contributors to the differences between members of the grass family

Diverse Applications of Nanomedicine

The design and use of materials in the nanoscale size range for addressing medical and health-related issues continues to receive increasing interest. Research in nanomedicine spans a multitude of areas, including drug delivery, vaccine development, antibacterial, diagnosis and imaging tools, wearable devices, implants, high-throughput screening platforms, etc. using biological, nonbiological, biomimetic, or hybrid materials. Many of these developments are starting to be translated into viable clinical products. Here, we provide an overview of recent developments in nanomedicine and highlight the current challenges and upcoming opportunities for the field and translation to the clinic. \ua9 2017 American Chemical Society

Synthesis and Acoustic Study of a New Tung Oil-Based Polyurethane Composite Foam with the Addition of Miscanthus Lutarioriparius

Polyurethane foam is commonly used in the automobile industry due to its favorable acoustic performances. In this study, a new tung oil-based polyurethane composite foam (TOPUF) was prepared by a one-step method. Different forms and contents of miscanthus lutarioriparius (ML) were used in TOPUF for improving acoustic performance. Polyurethane foams were characterized by means of Fourier transform infrared and SEM. The acoustic properties and mechanical properties of TOPUF, obtained with ML, were determined and compared with pure petroleum-based polyurethane foam. The results illustrate that the modification of TOPUF with the ML has a positive effect on the acoustic and mechanical properties in comparison to the unmodified foam. TOPUF obtained with ML powders has better acoustic performance than that obtained with ML strips. The optimum acoustic performance is achieved at the filler content of 0.3 wt%. The average sound absorption coefficient and transmission loss can reach 0.518, and 19.05 dB, respectively