Insights into the role of nucleotide methylation in metabolic-associated fatty liver disease

Metabolic-associated fatty liver disease (MAFLD) is a chronic liver disease characterized by fatty infiltration of the liver. In recent years, the MAFLD incidence rate has risen and emerged as a serious public health concern. MAFLD typically progresses from the initial hepatocyte steatosis to steatohepatitis and then gradually advances to liver fibrosis, which may ultimately lead to cirrhosis and carcinogenesis. However, the potential evolutionary mechanisms still need to be clarified. Recent studies have shown that nucleotide methylation, which was directly associated with MAFLD’s inflammatory grading, lipid synthesis, and oxidative stress, plays a crucial role in the occurrence and progression of MAFLD. In this review, we highlight the regulatory function and associated mechanisms of nucleotide methylation modification in the progress of MAFLD, with a particular emphasis on its regulatory role in the inflammation of MAFLD, including the regulation of inflammation-related immune and metabolic microenvironment. Additionally, we summarize the potential value of nucleotide methylation in the diagnosis and treatment of MAFLD, intending to provide references for the future investigation of MAFLD

Rare Gas Adsorption to Silver-Exchanged Zeolites

The adsorption of rare gas atoms to silver aluminosilicate has been investigated using density functional theory (DFT) with the local density approximation, generalized gradient approximation, and dispersion correction. The adsorption energies of rare gas atoms to the honeycomb lattice of silver aluminosilicate were calculated, and the results are discussed. The relationship between the electric charge density distribution and the adsorption energy is discussed. It indicates that the xenon atom has the most electrons to affect the van der Waals dispersion, so it has the highest minimum charge density, strongest polarization, most spacious spherical scope, and most favorable adsorption on silver zeolites

Reconstructed springtime (March–June) precipitation tracked by tree rings dating back to 1760 CE in the Qinling-Bashan mountainous area

In recent decades, considerable advances have been made in dendroclimatic reconstruction in the eastern monsoon region of China. However, understanding of long-term hydroclimatic changes has not been comprehensive due to the complexity of the regional geography in China's north-south transitional zone. Growth-climate response analysis indicated that springtime precipitation is the main factor limiting the radial growth of pine trees in the Qinling-Bashan mountainous area. Based on the three tree ring chronologies distributed in the southeast of Shaanxi Province, we developed a March–June precipitation reconstruction spanning 1760–2020 CE for the Qinling-Bashan mountainous area. Precipitation reconstruction accounts for 40.6% of the total precipitation variance during the instrumental period 1955–2016. Spatial correlation analysis indicated that the precipitation reconstruction recorded similar common precipitation signals for the eastern Qinling Mountains and the Yangtze-Huai River Basin. The results of the superposed epoch analysis (SEA) revealed that low precipitation was one of the main causes of severe drought and locust plague events. The preliminary synoptic climatology analysis showed that our reconstructed precipitation is closely linked to the El Niño-Southern Oscillation (ENSO) and Indian Ocean Dipole (IOD) variability.Fil: Wang, Shijie. Yunnan University; ChinaFil: Man, Wenmin. Chinese Academy of Sciences; República de ChinaFil: Chen, Feng. Yunnan University; China. China Meteorological Administration; ChinaFil: Chen, Youping. Yunnan University; ChinaFil: Yu, Shulong. China Meteorological Administration; ChinaFil: Cao, Honghua. Yunnan University; ChinaFil: Hu, Mao. Yunnan University; ChinaFil: Hou, Tiyuan. Yunnan University; ChinaFil: Hadad, Martín Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Centro de Investigaciones de la Geosfera y Biosfera. Universidad Nacional de San Juan. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones de la Geosfera y Biosfera; ArgentinaFil: Roig Junent, Fidel Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; Argentina. Universidad Mayor; Chil