AN OVERVIEW ON BILAYERED TABLET TECHNOLOGY

Bilayer tablet is new novel of tablet for the successful development of controlled release formulation along with many  features to provide a way of successful drugdelivery system. Bi-layer tablet is suitable for sequential release of two drugs incombination, separate two incompatible substances and also for sustained release tablet in which one Layer is immediaterelease as initial dose and second layer is maintenance dose. So use ofbi-layer tablets is a very differentaspectfor anti-hypertensive, diabetic, anti-inflammatory and analgesic drugs where combination therapy is often used.  Bi-layer tablets have been developed to achieve modified release of drug. Bilayer tabletis improved beneficial technology to overcome the shortcoming of the single layered tablet. In the case of bilayered tablets drug release can be rendered almost unidirectional if the drug can be incorporated in the upper non adhesive layer its delivery occurs into the whole oral cavity.To reduce capital investment, quite often existing but modified tablet presses are used to develop and produce such tablets. The present article explains why the production and development of quality bi-layer tablets needs to be carried out on purpose-built tablet presses to overcome common bi-layer problems, such as hardness, insufficient, layer-separation, inaccurate individual layer weight control, reduced yield, cross-contamination between the layers, etc. Using a modified tablet press may therefore not be your best approach to producing a quality bi-layer tablet under GMP-conditions. Keywords:Approaches, Bilayer tablets, OROS push pull technology, DUROS technology,immediate release, GMP requirements for bilayer tablet

FORMULATION DEVELOPMENT AND EVALUATION OF SOLID LIPID NANOPARTICLES OF ACECLOFENAC USING SOLVENT INJECTION METHOD.

Solid lipid nanoparticles (SLN) of aceclofenac were prepared by solvent injection method. Glyceryl behenate (Compritol 888 ATO) was used as lipid core, and Poloxamer 188 as the surfactant. Isopropyl alcohol (IPA) was used to dissolve both lipid and drug. The mean particle size measured by laser diffraction (LD) was 226.9 nm and the surface morphology was determined by scanning electron microscopy. The entrapment efficiency (EE) was found to be 90%. In-vitro dissolution was found to be 90.22%

Formulation development and evaluation of gastroretentive mucoadhesive tablets of glimepiride using natural polymers

Glimepiride, a third-generation sulfonylurea is poorly soluble anti-diabetic drug. Currently, the use of natural gums and mucilage is of increasing importance in pharmaceutical formulations as valuable drug excipients. Natural plant-based materials are economic, free of side effects, biocompatible and biodegradable. The development of mucoadhesive sustained release drug delivery system is recommended in order to enhance the bioavailability. A mucoadhesive tablets were developed using the natural polymer sodium alginate and gum tragacanth. Mucoadhesion is a complex phenomenon which involves wetting, adsorption and interpenetration of polymer chains. The tablets of glimepiride were prepared by direct compression method. Pre-compression parameters were evaluated. The tablets were evaluated for post-compression parameters such as thickness, hardness, average weight, friability and In vitro release studies. All the compositions were resulted in adequate pharmacopoeial limits. The varying concentration of polymers was found to affect on in-vitro drug release and mucoadhesive strength. In vitro drug release of gastro retentive tablet of glimepiride shown that the formulation F5 was found to be the best formulation as it releases 98.78%.  Glimepiride in a sustain release manner for an extended period of time (up to 12 hrs). The release data was fitted to various mathematical models such as higuchi, korsmeyer-peppas, first order and zero order to evaluate the kinetics and mechanism of the drug release. Prepared tablets of glimepiride may prove to be a potential candidate for safe and effective controlled drug delivery over an extended period of time for gastro retentive drug delivery system. Keywords: Glimepiride, Gastro retentive, Anti-diabetic drug, Direct compression metho

Synthesized Silver Nanoparticle Loaded Gel of Curcuma Caesia for Effective Treatment of Acne

Objective: The objective of our research is to prepare silver nanoparticles from the rhizome extract of Curcuma caesia and develop topical herbal gel formulation for the effective treatment of acne. Methods: In this present study, silver nanoparticles were synthesized using hydroalcoholic extract of Curcuma caesia rhizome. Silver nanoparticles loaded gels were evaluated for pH, viscosity, spreadability, in vitro release, estimation of total flavonoids and alkaloid content and antibacterial (propioni bacterium acne) studies. Results: The synthesized silver nanoparticles were stable, spherical shape with average particle size of 220.5 nm. The results obtained in the developed formulation showed no lumps, had uniform color dispersion and were free from any fiber and particle. It was also observed to have easy washablity, good spreadability, pH was found to be 6.58±0.02 and 7.02±0.01 similar to pH of the skin. The antibacterial study of the developed formulation showed inhibitory activity against Propioni bacterium acne. Synthesized silver nanoparticle loaded gel displayed drug release of optimized formulation F3 follows the Higuchi kinetic model, and the mechanism is found to be non Fickian/anomalous according to Korsmeyer–Peppas. Silver nanoparticles effectively inhibited the growth of both microorganism indicating good antibacterial properties. Conclusion: Synthesis of silver nanoparticles using Curcuma caesia is a new, green method and not reported yet, as per literature survey done for this project. Successful synthesis and evaluation of silver nanoparticles was proved by the in-vitro study. Keywords: Curcuma caesia, Silver nanoparticles, Propioni bacterium acne, Acne, Flavonoids content, Alkaloid content, Antibacterial

Book of Abstracts of the 2nd International Conference on Applied Mathematics and Computational Sciences (ICAMCS-2022)

It is a great privilege for us to present the abstract book of ICAMCS-2022 to the authors and the delegates of the event. We hope that you will find it useful, valuable, aspiring, and inspiring. This book is a record of abstracts of the keynote talks, invited talks, and papers presented by the participants, which indicates the progress and state of development in research at the time of writing the research article. It is an invaluable asset to all researchers. The book provides a permanent record of this asset. Conference Title: 2nd International Conference on Applied Mathematics and Computational SciencesConference Acronym: ICAMCS-2022Conference Date: 12-14 October 2022Conference Organizers: DIT University, Dehradun, IndiaConference Mode: Online (Virtual