SPACEFLIGHT HYPERION DATA RADIATION CALIBRATION PRELIMINARY STUDY

Radiometric calibration is the basis of both hyperspectral data applications and quantitative remote sensing. While at present, there is no good and suitable method for radiometric calibration in the aerospace hyperspectral data. The paper uses the highest spectral resolution Hyperion EO-1 satellite data in current world Spaceflight sensor as information source, using a variety of calibration models, which including of the calibration model based on atmospheric radiation theory, conversion model based on the characteristics of the image itself(Flat Field Model, IAR Reflectance Model, Log Residuals Modified Model, e.g.), linear model based on the experience of the ground calibration and so on, implementation Spaceflight hyperspectral data calibration study. Through the above model calibration contrast, and combined analysis with the field measured spectral curve, then we draw the conclusion that the calibration model based on atmospheric radiation theory is the best radiation calibration method for Spaceflight Hyperion data, so we provide the quality assurance for the effective application of Spaceflight Hyperion data. 1

Neural Dysfunction Underlying Working Memory Processing at Different Stages of the Illness Course in Schizophrenia:A Comparative Meta-analysis

Schizophrenia (SCZ), as a chronic and persistent disorder, exhibits working memory deficits across various stages of the disorder, yet the neural mechanisms underlying these deficits remain elusive with inconsistent neuroimaging findings. We aimed to compare the brain functional changes of working memory in patients at different stages: clinical high risk (CHR), first-episode psychosis (FEP), and long-term SCZ, using meta-analyses of functional magnetic resonance imaging (fMRI) studies. Following a systematic literature search, fifty-six whole-brain task-based fMRI studies (15 for CHR, 16 for FEP, 25 for long-term SCZ) were included. The separate and pooled neurofunctional mechanisms among CHR, FEP and long-term SCZ were generated by Seed-based d Mapping toolbox. The CHR and FEP groups exhibited overlapping hypoactivation in the right inferior parietal lobule, right middle frontal gyrus, and left superior parietal lobule, indicating key lesion sites in the early phase of SCZ. Individuals with FEP showed lower activation in left inferior parietal lobule than those with long-term SCZ, reflecting a possible recovery process or more neural inefficiency. We concluded that SCZ represent as a continuum in the early stage of illness progression, while the neural bases are inversely changed with the development of illness course to long-term course

Roles of microRNA on cancer cell metabolism

Advanced studies of microRNAs (miRNAs) have revealed their manifold biological functions, including control of cell proliferation, cell cycle and cell death. However, it seems that their roles as key regulators of metabolism have drawn more and more attention in the recent years. Cancer cells display increased metabolic autonomy in comparison to non-transformed cells, taking up nutrients and metabolizing them in pathways that support growth and proliferation. MiRNAs regulate cell metabolic processes through complicated mechanisms, including directly targeting key enzymes or transporters of metabolic processes and regulating transcription factors, oncogenes / tumor suppressors as well as multiple oncogenic signaling pathways. MiRNAs like miR-375, miR-143, miR-14 and miR-29b participate in controlling cancer cell metabolism by regulating the expression of genes whose protein products either directly regulate metabolic machinery or indirectly modulate the expression of metabolic enzymes, serving as master regulators, which will hopefully lead to a new therapeutic strategy for malignant cancer. This review focuses on miRNA regulations of cancer cell metabolism,including glucose uptake, glycolysis, tricarboxylic acid cycle and insulin production, lipid metabolism and amino acid biogenesis, as well as several oncogenic signaling pathways. Furthermore, the challenges of miRNA-based strategies for cancer diagnosis, prognosis and therapeutics have been discussed

Maternal control of axial–paraxial mesoderm patterning via direct transcriptional repression in zebrafish

AbstractAxial–paraxial mesoderm patterning is a special dorsal–ventral patterning event of establishing the vertebrate body plan. Though dorsal–ventral patterning has been extensively studied, the initiation of axial–paraxial mesoderm pattering remains largely unrevealed. In zebrafish, spt cell-autonomously regulates paraxial mesoderm specification and flh represses spt expression to promote axial mesoderm fate, but the expression domains of spt and flh initially overlap in the entire marginal zone of the embryo. Defining spt and flh territories is therefore a premise of axial–paraxial mesoderm patterning. In this study, we investigated why and how the initial expression of flh becomes repressed in the ventrolateral marginal cells during blastula stage. Loss- and gain-of-function experiments showed that a maternal transcription factor Vsx1 is essential for restricting flh expression within the dorsal margin and preserving spt expression and paraxial mesoderm specification in the ventrolateral margin of embryo. Chromatin immunoprecipitation and electrophoretic mobility shift assays in combination with core consensus sequence mutation analysis further revealed that Vsx1 can directly repress flh by binding to the proximal promoter at a specific site. Inhibiting maternal vsx1 translation resulted in confusion of axial and paraxial mesoderm markers expression and axial–paraxial mesoderm patterning. These results demonstrated that direct transcriptional repression of the decisive axial mesoderm gene by maternal ventralizing factor is a crucial regulatory mechanism of initiating axial–paraxial mesoderm patterning in vertebrates

Bis[2,4-dibromo-6-(n-propyl­imino­methyl)phenolato-κ2 N,O]cobalt(II)

In the title complex, [Co(C10H10Br2NO)2], the CoII atom lies on a twofold rotation axis, the N2O2 units having distorted tetra­hedral coordination environments comprising two bidentate chelate 2,4-dibromo-6-(n-propyl­imino­meth­yl)phenolate Schiff base ligands [Co—N = 1.989 (3) Å, Co—O = 1.924 (2) Å and O/N—Co—O/N = 94.53 (10)–125.40 (15)°]. In the crystal structure, the mol­ecules are linked via weak inter­molecular C—H⋯O hydrogen bonds [3.334 (5) Å] and there are also short inversion-related intermolecular Br⋯Br contacts [3.4263 (6) Å