7,292 research outputs found
Transient tether between the SRP RNA and SRP receptor ensures efficient cargo delivery during cotranslational protein targeting
Kinetic control of macromolecular interactions plays key roles in biological regulation. An example of such control occurs in cotranslational protein targeting by the signal recognition particle (SRP), during which the SRP RNA and the cargo both accelerate complex assembly between the SRP and SRP receptor FtsY 10^2-fold. The molecular mechanism underlying these rate accelerations was unclear. Here we show that a highly conserved basic residue, Lys399, on the lateral surface of FtsY provides a novel RNA tetraloop receptor to mediate the SRP RNA- and cargo-induced acceleration of SRP–FtsY complex assembly. We propose that the SRP RNA, by using its tetraloop to interact with FtsY–Lys399, provides a transient tether to stabilize the early stage and transition state of complex formation; this accelerates the assembly of a stable SRP–FtsY complex and allows the loading of cargo to be efficiently coupled to its membrane delivery. The use of a transient tether to increase the lifetime of collisional intermediates and reduce the dimension of diffusional search represents a novel and effective mechanism to accelerate macromolecular interactions
Quasinormal modes in Schwarschild black holes due to arbitrary spin fields
The Newman-Penrose formalism is used to deal with the massless scalar,
neutrino, electromagnetic, gravitino and gravitational quasinormal modes (QNMs)
in Schwarzschild black holes in a united form. The quasinormal mode frequencies
evaluated by using the 3rd-order WKB potential approximation show that the
boson perturbations and the fermion perturbations behave in a contrary way for
the variation of the oscillation frequencies with spin, while this is no longer
true for the damping's, which variate with in a same way both for boson and
fermion perturbations.Comment: 11 pages, 3 figure
Thermal entanglement in a two-spin-qutrit system under a nonuniform external magnetic field
The thermal entanglement in a two-spin-qutrit system with two spins coupled
by exchange interaction under a magnetic field in an arbitrary direction is
investigated. Negativity, the measurement of entanglement, is calculated. We
find that for any temperature the evolvement of negativity is symmetric with
respect to magnetic field. The behavior of negativity is presented for four
different cases. The results show that for different temperature, different
magnetic field give maximum entanglement. Both the parallel and antiparallel
magnetic field cases are investigated qualitatively (not quantitatively) in
detail, we find that the entanglement may be enhanced under an antiparallel
magnetic field.Comment: 2 eps figure
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