CLINICAL TRIAL OF DRUG VYAN UTKSHEPAHARA GHAN VATI (KALPIT YOG) IN DIABETES (NIDDM) INDUCED HYERTENSION.

Due to the unwholesome diet, sedentary life style, day by day our country is facing the increasing burden of the patients of diabetes induced high blood pressure, and obesity. Our country is becoming the capital of these diseases. These diseases mostly treated by allopathic medicines which are having considerable side effects and could not be used on long term basis. So conclusion is that in these disease, the dose of allopathic medicines and disease gradually progresses and in addition due to the side effects of allopathic medicines, it is better that these diseases should be treated by Ayurvedic medicines

COMPARATIVE STUDY OF THE SHIVA GUGGULU AND SIMHANADA GUGGULU IN THE MANAGEMENT OF AMAVATA (RHEUMATOID ARTHRITIS)

Objective: Comparison of effectiveness of two drugs (Shiva Guggulu and Simhanada Guggulu in the same dose of both drug given separately in two different groupA and Group B) on patients of Amavata. Methods: Patients between 18-60 y of age with classical features of Amavata [9] from OPD and IPD of Government autonomous Ayurvedic College and Hospital were selected for the present work; irrespective of their sex, religion, education, etc. Detailed research Performa was prepared to incorporate all the signs and symptoms of the disease Amavata is the second most common joint disorders. Nowadays erroneous dietary habits, lifestyle and environment have led to various autoimmune disorders i.e. Amavisajanya Vikaara and Amavata is one among them. Rheumatoid arthritis can be correlated with Amavata in view of its clinical features. Many research studies have been done to solve this clinical enigma, but an effective, safe, less complicated treatment is still required for the management of Amavata. In the present study, 24 patients of Amavata were registered and randomly grouped into two. In group A, Shiva Guggulu 6 g/day in divided doses and in group B, Simhanada Guggulu 6 g/day in divided doses were given for 8 w. On analysis of the results, it was found that Simhanada Guggulu provided better results as compared to Shiva Guggulu in the management of Amavata. In group A, the mean score of grip strength was 1.14 before treatment, which was reduced to 0.57 after treatment, with 50% relief. It was statistically insignificant. The mean score of grip strength in group B was 2.4 before treatment, which was reduced to 1.5 after treatment, with 37.5% relief. It was statistically highly significant. Results: Before treatment the mean score of walking time in group A was 2, which was reduced to 1 after treatment, with 50% relief. It was statistically insignificant. The mean score of walking time in group B was 1.75 before treatment, which was reduced to 0.75 after treatment, with 45.71% relief. It was statistically significant. In group A, the mean score of foot pressure was 1 before treatment, which was decreased to 0.66 after treatment, with 33.33% relief. It was statistically insignificant. The mean score of foot pressure in group B was 2.3 before treatment, which was decreased to 1.4 after treatment with, 39.13% relief. It was statistically highly significant. In group A, the mean score of general functional capacity was 1.33 before treatment, which was reduced to 0.66 after treatment, with 50% relief. It was statistically highly significant. The mean score of general functional capacity in group B was 1.66 before treatment, which was reduced to 0.66 after treatment, with 60% relief and was statistically insignificant. In group A, the mean score of the degree of disease activity was 1.75 before treatment, which was reduced to 1 after treatment, with 42.85% relief. It was statistically highly significant. The mean score of the degree of disease activity in group B was 1.5 before treatment, which was reduced to 0.75 after treatment, with 50% relief. It was statistically significant. Regarding ESR value, the mean scores before treatment in A and B groups were 54.5 and 55.2, respectively, and they were reduced to 45.3 and 40.1, respectively, after treatment. Group A percentage relief was 16.88%, while in group B it was 27.35%. An apparent difference in improvement of all the cardinal symptoms was observed with the treatment. On comparing Group B proved to be better than Group A. Statistically highly significant difference was found in the improvement of Sandhigraha and statistically significant difference was found in the improvement of Sandhishoola and Sparshasahyata by Simhanada Guggulu than Shiva Guggulu, whereas insignificant difference was observed in the improvement of Sandhishotha. So, from the obtained data it may be inferred that group B is more effective than groupA. Conclusion: It was observed from the treatment that Simhanada Guggulu provided comparatively better relief in cardinal signs and symptoms of Amavata. Keywords: Agni, Ama, Amavata, Rheumatoid arthritis, Shiva Guggulu, Simhanada Guggul

A high grade pleural based sarcoma in a patient with rheumatoid arthritis and a 7-year history of anti-TNF alpha therapy

The use of anti-tumour necrosis factor alpha (anti-TNFα) therapies has increased over the past few years. Concerns have been raised about the theoretical increased risk of malignancy in patients receiving these therapies. We report a case of an extremely rare high grade pleural based sarcoma in a patient with rheumatoid arthritis and a 7-year history of anti-TNFα therapy

CLINICAL-COMPARATIVE STUDY OF VIRECHAN & PAKSHAGHATARI GUGGULU ON PAKSHAGHAT W.R.S. TO HEMPIPLIGIA.

In the present era due to speeder change of the civilization, human habits and life style continuously changing without any consideration of their benefits or harms Adaptation of new diets, movement with fast moving vehicles, maintenance of wrong postures, avoidance or over-indulgence of exercise, suppression of natural urges, anxiety strain etc. of the present life are becoming responsible for increasing incidence of Vatavyadhi like Pakshaghat (Hemiplegia.) These diseases mostly treated by allopathic medicines(high dose of corticosteroids) which are having considerable side effects and could not be used on long term basis. So conclusion is that in these disease, the dose of allopathic medicines and disease gradually progresses and in addition due to the side effects of allopathic medicines, it is better that these diseases should be treated by Ayurvedic medicines.Â

Skeletal muscle adiposity is associated with physical activity, exercise capacity and fibre shift in COPD

Quadriceps muscle phenotype varies widely between patients with chronic obstructive pulmonary disease (COPD) and cannot be determined without muscle biopsy. We hypothesised that measures of skeletal muscle adiposity could provide noninvasive biomarkers of muscle quality in this population. In 101 patients and 10 age-matched healthy controls, mid-thigh cross-sectional area, percentage intramuscular fat and skeletal muscle attenuation were calculated using computed tomography images and standard tissue attenuation ranges: fat -190– -30 HU; skeletal muscle -29–150 HU. Mean±sd percentage intramuscular fat was higher in the patient group (6.7±3.5% versus 4.3±1.2%, p = 0.03). Both percentage intramuscular fat and skeletal muscle attenuation were associated with physical activity level, exercise capacity and type I fibre proportion, independent of age, mid-thigh cross-sectional area and quadriceps strength. Combined with transfer factor of the lung for carbon monoxide, these variables could identify >80% of patients with fibre type shift with >65% specificity (area under the curve 0.83, 95% CI 0.72–0.95). Skeletal muscle adiposity assessed by computed tomography reflects multiple aspects of COPD related muscle dysfunction and may help to identify patients for trials of interventions targeted at specific muscle phenotypes