Gender Bias and Organ Transplantation in Nepal

Women in Nepal are less likely to receive proper, high quality medical care than their male relatives. Live-donor kidney transplantation provides a compelling example of such disparities, as 84% of recipients are male, 75% of donors are female and most kidneys are transferred from mother to son and from wife to husband. In the case of transplantation, women are not just denied healthcare, they are also responsible for the health of their male kin. Based on semi-structured ethnographic interviews with transplant patients, organ donors, dialysis patients and relatives, this paper elaborates on the social and economic factors that have created an extreme gender bias in transplantation. We argue that women, whose livelihoods largely depend on their husbands, donate kidneys out of self-protection and a sense of duty. Conversely, men receive kidneys but rarely donate them to women, because the health of men is a more productive economic investment than the health of women. We reject the notion that wives are directly coerced or pressured into donating kidneys to their husbands. Rather, we argue that female kidney donors make thoughtful, independent decisions that serve their best interests, and allow them to assert some control over their lives. It is, however, Nepal’s patriarchal society that both necessitates and limits such assertions of power

Analysing the Impact of Decoupling at a Regional Level in Ireland: A Farm Level Dynamic Linear Programming Approach

This paper describes a methodology to assess the impact of the decoupling of payments on Irish farms at a regional level. The methodology is based on a farm level dynamic linear programming model which optimises regional gross margin under a set of constraints. Regionally representative farms are selected using cluster analysis. The model maximises aggregate gross margins from all the farm types in a region allowing land and milk quota to transfer between farms within the region. The model is estimated for a baseline scenario, assuming no policy change, and under a decoupled scenario where farm payments are fully decoupled from production. An example of an impact study at the Border region in Ireland is presented in this paper to demonstrate the methodology.Decoupling, Linear Programming, Cluster analysis, Agricultural policy, Regional level, Agricultural and Food Policy,

A prospect of moving towards free milk quota market in Ireland – will milk quota movement follow efficiency?

Quota trade in Ireland is ‘ring fenced’ to milk processors where farmers are not allowed to trade milk quota outside their designated milk processor. This ensures milk production staying within a region but has implications for the efficiency of milk production. In this paper, we simulated a free milk quota market in Ireland and compared the results with a milk quota exchange which was ring fenced to determine if the quota move from an inefficient region to a more efficient region. The results show that quota indeed follow efficiency of production when there is restriction over trade area.Milk quota trade, Irish quota market, Farm level model, Agricultural and Food Policy,

Impacts of \u3ci\u3eYartsa Gunbu\u3c/i\u3e Harvesting on Alpine Ecosystems in the Barun Valley, Makalu-Barun National Park, Nepal

Around 2003, the highly valuable medicinal fungi Ophiocordyceps sinensis (Nepali: yartsa gunbu) began to be commercially harvested in the remote Barun valley of the Makalu-Barun National Park and Buffer Zone, eastern Nepal. Since then, an estimated 3,000 collectors per year have visited the valley each harvesting season, placing new pressures upon its subalpine and alpine landscapes. A review of the yartsa gunbu literature suggested that its harvesting throughout highland India, Nepal, Bhutan, and China has brought important economic benefits, but that it has often been accompanied by a corresponding increase in negative environmental impacts such as alpine shrub destruction, wildlife poaching, and improper garbage disposal. Adverse social impacts reported have included an increase in violence, occasional murder, and the erosion of traditional values. In an attempt to determine if similar phenomena were occurring within the Barun valley, east Nepal, we conducted a month-long study of yartsa gunbu harvesting practices between May and June of 2016. Unlike other regions of the Himalaya, we found that violence and social unrest due to harvesting competition were unheard of in the Barun, which we link to the (a) lower market value of yartsa gunbu harvested there when compared to other regions, and (b) the recognized role of yartsa gunbu as a supplemental and livelihood diversifying income generation opportunity instead of a sole source of new income. Since its collection and sale were legalized by the Government of Nepal in 2001, the concurrent development of locally responsive yartsa gunbu harvesting policies and practices can also be linked to the general absence of environmental disturbance that we found

Variations in CCL3L gene cluster sequence and non-specific gene copy numbers

<p>Abstract</p> <p>Background</p> <p>Copy number variations (CNVs) of the gene CC chemokine ligand 3-like1 (<it>CCL3L1</it>) have been implicated in HIV-1 susceptibility, but the association has been inconsistent. <it>CCL3L1 </it>shares homology with a cluster of genes localized to chromosome 17q12, namely <it>CCL3</it>, <it>CCL3L2</it>, and, <it>CCL3L3</it>. These genes are involved in host defense and inflammatory processes. Several CNV assays have been developed for the <it>CCL3L1 </it>gene.</p> <p>Findings</p> <p>Through pairwise and multiple alignments of these genes, we have shown that the homology between these genes ranges from 50% to 99% in complete gene sequences and from 70-100% in the exonic regions, with <it>CCL3L1 </it>and <it>CCL3L3 </it>being identical. By use of MEGA 4 and BioEdit, we aligned sense primers, anti-sense primers, and probes used in several previously described assays against pre-multiple alignments of all four chemokine genes. Each set of probes and primers aligned and matched with overlapping sequences in at least two of the four genes, indicating that previously utilized RT-PCR based CNV assays are not specific for only <it>CCL3L1</it>. The four available assays measured median copies of 2 and 3-4 in European and African American, respectively. The concordance between the assays ranged from 0.44-0.83 suggesting individual discordant calls and inconsistencies with the assays from the expected gene coverage from the known sequence.</p> <p>Conclusions</p> <p>This indicates that some of the inconsistencies in the association studies could be due to assays that provide heterogenous results. Sequence information to determine CNV of the three genes separately would allow to test whether their association with the pathogenesis of a human disease or phenotype is affected by an individual gene or by a combination of these genes.</p