General Relativistic MHD Simulations of the Gravitational Collapse of a Rotating Star with Magnetic Field as a Model of Gamma-Ray Bursts

We have performed 2.5-dimensional general relativistic magnetohydrodynamic (MHD) simulations of the gravitational collapse of a magnetized rotating massive star as a model of gamma ray bursts (GRBs). This simulation showed the formation of a disk-like structure and the generation of a jet-like outflow inside the shock wave launched at the core bounce. We have found the jet is accelerated by the magnetic pressure and the centrifugal force and is collimated by the pinching force of the toroidal magnetic field amplified by the rotation and the effect of geometry of the poloidal magnetic field. The maximum velocity of the jet is mildly relativistic ($\sim$ 0.3 c).Comment: 4 pages, 1 figure, aipTEX, contribution to the 2003 GRB Conference, held at Santa Fe, N

General Relativistic Magnetohydrodynamic Simulations of Collapsars

We have performed 2.5-dimensional general relativistic magnetohydrodynamic (MHD) simulations of the gravitational collapse of a magnetized rotating massive star as a model of gamma ray bursts (GRBs). The current calculation focuses on general relativistic MHD with simplified microphysics (we ignore neutrino cooling, physical equation of state, and photodisintegration). Initially, we assume that the core collapse has failed in this star. A few $M_{\odot}$ black hole is inserted by hand into the calculation. The simulations presented in the paper follow the accretion of gas into a black hole that is assumed to have formed before the calculation begins.The simulation results show the formation of a disk-like structure and the generation of a jetlike outflow inside the shock wave launched at the core bounce. We have found that the jet is accelerated by the magnetic pressure and the centrifugal force and is collimated by the pinching force of the toroidal magnetic field amplified by the rotation and the effect of geometry of the poloidal magnetic field. The maximum velocity of the jet is mildly relativistic (0.3c). The velocity of the jet becomes larger as the initial rotational velocity of stellar matter gets faster. On the other hand, the dependence on the initial magnetic field strength is a bit more complicated: the velocity of the jet increases with the initial field strength in the weak field regime, then is saturated at some intermediate field strength, and decreases beyond the critical field strength. These results are related to the stored magnetic energy determined by the balance between the propagation time of the Alfven wave and the rotation time of the disk (or twisting time).Comment: 36 pages, 2 tables, 15 figures, ApJ May 2004, in pres

High levels of soluble C5b-9 complex in dialysis fluid may predict poor prognosis in peritonitis in peritoneal dialysis patients

Background We searched for indicators to predict the prognosis of infectious peritonitis by measuring levels of complement proteins and activation products in peritoneal dialysis (PD) fluid (PDF) of patients at early stages of peritonitis. We retrospectively analyzed the relationship between the levels of sC5b-9, C3 and C4 in PDF and the subsequent clinical prognosis. Methods We measured levels of sC5b-9, C3 and C4 in PDF on days 1, 2 and 5 post-onset of peritonitis in 104 episodes of infectious peritonitis in PD patients from 2008 and retrospectively compared levels with clinical outcomes. Further analysis for the presence of causative microorganisms or to demonstrate bacterial culture negative peritonitis was performed and correlated with change of levels of sC5b-9 in PDF. Results When PD patients with peritonitis were divided into groups that either failed to recover from peritonitis and were finally withdrawn from PD (group 1; n = 25) or recovered (group 2; n = 79), levels of sC5b-9, C3 and C4 in PDF were significantly higher in group 1 patients compared to those in group 2 on day5. Analysis of microorganisms showed significantly higher sC5b-9 levels in PDF of peritonitis cases caused by culture negative peritonitis in group 1 compared with group 2 when we analyzed for individual microorganisms. Of note, on day5, the sC5b-9 levels in PDF were similarly high in peritonitis caused by fungi or other organisms. Conclusion Our results suggested that levels of complement markers in PDF, especially sC5b-9, have potential as surrogate markers to predict prognosis of PD-related peritonitis

Connective tissue growth factor is correlated with peritoneal lymphangiogenesis.

Lymphatic absorption in the peritoneal cavity may contribute to ultrafiltration failure in peritoneal dialysis (PD). Lymphatic vessels develop during PD-related peritoneal fibrosis. Connective tissue growth factor (CTGF, also called CCN2) is an important determinant of fibrotic tissue remodeling, but little is known about its possible involvement in lymphangiogenesis. In this study, we investigated the relationship between CTGF and peritoneal lymphangiogenesis. A positive correlation was observed between vascular endothelial growth factor-C (VEGF-C), a major lymphangiogenic growth factor, and the CTGF concentration in human PD effluents. CTGF expression was positively correlated with expression of lymphatic markers and VEGF-C in human peritoneal biopsies. We found a positive correlation between the increase in CTGF and the increase in VEGF-C in cultured human peritoneal mesothelial cells (HPMCs) treated with transforming growth factor-β1 (TGF-β1). The diaphragm is a central player in peritoneal lymphatic absorption. CTGF expression was also correlated with expression of VEGF-C and lymphatics in a rat diaphragmatic fibrosis model induced by chlorhexidine gluconate (CG). Furthermore, CTGF gene deletion reduced VEGF-C expression and peritoneal lymphangiogenesis in the mouse CG model. Inhibition of CTGF also reduced VEGF-C upregulation in HPMCs treated with TGF-β1. Our results suggest a close relationship between CTGF and PD-associated lymphangiogenesis

Theoretical analysis of mixed irradiation (3)

As the model we proposed last year was contradictory to experimental data, we revised again the models for mixed irradiation by Zaider and Rossi and by Suzuki, substituting a \u27reciprocal-time\u27 pattern of repair function for a first-order one in reduction and interaction factors of the models, although we used a second order repair function last year. The reduction factor, which reduces the contribution of the square of a dose to cell killing in the models, and the interaction factor, which also reduces the contribution of the interaction of two or more doses of different types of radiation, were formulated by using the \u27reciprocal-time\u27 pattern of repair function. These newly modified models for mixed irradiation could express or predict cell survival more accurately than the older ones, especially when irradiation is prolonged at low dose rates. We present survival curves of cells calculated from the newly and the older models of assumptive simultaneous mixed irradiation with two or three types of radiation