1 research outputs found
Association of umbilical cord lipid profile with gestational age and birth weight in newborns in Mahdieh Hospital in 2017
BBackground and Aim: Ischemic heart diseases are the most common cause of mortality and morbidity in developed countries. The incidence of these disorders are increasing and the age of onset is on the decrease. The prevalence of risk factors such as obesity and hyperlipidemia is on the increase among children and adolescents. Various maternal and fetal factors can affect fetal fat levels. Therefore, the present study was designed to determine the relationship of the level of umbilical cord blood lipids with gestational age and birth weight in the newborns born in Mahdieh Hospital in 2017.
Material and Method: In this descriptive-analytical study we measured cord blood lipids levels of 375 newborns, born in Mahdieh Hospital in 2017. Newborns with known maternal or fetal complications were excluded from the study. Demographic, clinical and paraclinical data of the newborns and mothers were recorded in the questionnaire for every newborn and the relationship of the level of umbilical cord blood lipids (total cholesterol, VLDL, HDL, LDL, and triglyceride) with gestational age, birth weight, sex of the newborn, maternal age and BMI was evaluated. We used chi-square test to compare qualitative data and T-test, ANOVA, Kruskal-Wallis and Spearman correlation coefficient to compare quantitative data.
Results: This study included 375 single-birth infants (191 girls and 184 boys). The mean umbilical cord serum values for triglyceride in the preterm and term infants were 122.2±31.2 and 97.6±31.7 (p<0.001), and for VLDL were 24.2±6.0 and 19.5±6.6 (p<0.001) respectively. The respective values for mean serum triglyceride and VLDL levels in umbilical cord blood were 126.6±34.6 and 100.1±32.6 (p=0.011) in the newborns with birth weight of less than 2500 grams. Also mean serum triglyceride and VLDL levels in umbilical cord blood were 24.9±6.7 and 19.9±6.7 (p=0.020) in the newborns with birth weight of more than 2500 gram (2500-4000 grams and higher) respectively. The respective mean levels of umbilical cord blood triglyceride were 90.8±33.0, 101.6±32.8 and 110.2±31.6 (p=0.047) for SGA, AGA and LGA newborns. Newborns of the mothers with BMI≥25 had higher levels of triglyceride, VLDL and LDL compared to the newborns of the mothers with BMI < 25. The lipid levels of umbilical cord blood had no relationship with mother’s age. We used t-test, ANOVA, Kruskal-Wallis and Spearman correlation for quantitative and chi-square test for qualitative data analysis.
Conclusion: The results of this study showed that mean serum levels of triglyceride and VLDL of the umbilical cord blood is higher in the preterm newborns and newborns with birth weights of less than 2500 grams. SGA newborns had lower umbilical cord blood triglyceride levels compared to the other newborns. Newborns of the mothers with pre-pregnancy obesity had higher umbilical cord blood levels of triglyceride, VLDL and LDL. We did not find any relationship between the levels of umbilical cord blood lipids and age of the mothers