A Case of a Subepidermal Calcified Nodule on the Sole without Trauma

Subepidermal calcified nodule is an uncommon form of calcinosis cutis, which most commonly occurs in children. It usually presents as an asymptomatic, solitary verrucous nodule on the head and neck region, but occasionally as multiple lesions. Serum calcium and phosphorus levels are usually normal. Histopathology shows well-formed homogeneous eosinophilic material and granules in the upper dermis. Material in the dermis stained with von Kossa was positive. We report on an unusual case of a subepidermal calcified nodule occurring on the sole. A 21-month-old male presented with an oval-shaped, whitish, hard nodule measuring 5×5 mm on the left sole, without any previous history of trauma

Chromium-Amino Acid Conjugates as Elicitors in Chromium-Sensitized Guinea Pigs

Chromium-amino acid conjugates were isolated from systems initially containing either potassium dichromate and amino acid or chromic nitrate and amino acid. The elicitating properties of these chromium-amino acid conjugates were evaluated by intradermal injection of guinea pigs sensitized to chromium. Positive results were obtained with several conjugates. The conjugates prepared from chromic nitrate and ammo acid were stronger elicitors than those prepared from potassium dichromate and amino acid