Effectiveness of hypericum perforatum L. Phytosorbent as a part of complex therapy for acute non-specific bronchopneumonia

Respiratory pathology in calves, in particular acute non-specific bronchopneumonia, is extremely common, ranks second after gastrointestinal diseases and leads to significant economic losses. The effectiveness of antimicrobial agents of various pharmacological groups (tetracyclines, aminoglycosides, penicillins) has recently significantly decreased, which is associated with the formation of antibiotic-resistant strains of conditionally pathogenic bacteria. The problem of antibiotic resistance microorganisms that induce the development of an inflammatory process in the respiratory tract of calves forces the search for new therapi es, increasing the effectiveness of standard antibiotic therapy with the help of additional prescribing of various medicinal substances. The aim of the study was to study the effectiveness of the phytosorbent Hypericum Perforatum L. in the complex therapy of calves with acute non-specific bronchopneumonia. The therapeutic effect of Hypericum Perforatum L. phytosorbent was tested in the complex therapy of 97 calves with acute non-specific bronchopneumonia was studied. Calves aged 1.8±0.3 months and weighing 53.5±1.4 kg were selected for the experiment. For comparative study of therapeutic schemes, experimental animals were divided into two groups using the principle of paired analogues. Calves with bronchopneumonia-group I (n=42) were treated with the drug Florox at a dose of 1 ml per 15 kg of body weight, which corresponded to 20 mg/kg of Florfenicol, intramuscularly, twice with an interval of 48 hours. Calves with acute non-specific bronchopneumonia-group II (n=55) were also treated with the drug Florox at a dose of 1 ml per 15 kg of body weight intramuscularly, twice at 48-hour intervals with an additional prescription of phytosorbent Hypericum Perforatum L. at a dose of 5.0 g orally 1 time per day for 7 days. The effectiveness of therapy was evaluated by clinical and laboratory blood parameters. It was found that combined therapy of calves with acute non-specific bronchopneumonia with the use of Florfenicol and Hypericum Perforatum L. phytosorbent leads to a complete recovery 16.1 % more often than in animals treated with Florfenicol in a single mode. Combination of Florfenicol with Hypericum Perforatum L. statistically significant decreasing phenomena leukocytosis, increased phagocytic activity of neutrophils, reduced serum concentrations of C-reactive protein, α-globulin, β-globulin, the increase in the concentration of albumin, γ-globulin and IgG in the treatment of sick calves. In the blood of sick animals treated with a combination of Florfenicol with Hypericum Perforatum L. phytosorbent, compared with calves treated with Florfenicol in a single mode, the number of leukocytes in the peripheral blood significantly decreased and the phagocytic activity of neutrophilic leukocytes increased. These changes indicate a significant anti-inflammatory and immunomodulatory effect of Hypericum Perforatum L. in acute non-specific bronchopneumonia in calves. © 2020, Advanced Scientific Research. All rights reserved

Clinical and hematological parameters for selecting the optimal dose of the phytopreparation "deprim", containing an extract of the herb hypericum perforatum l., in husbandry

Only industrial technologies can provide a high level of profitability of pork production, which provides for year-round keeping of pigs in premises with maximum mechanization and automation of production processes. However, under such conditions, animals are exposed to a whole complex of stress factors, which negatively affects the state of the immune system. As you know, stress occurs when external environmental conditions do not correspond to the internal reserves of the body, which leads to its depletion and the development of a General adaptive syndrome, which is manifested by changes in the behavior of animals, their hormonal status and, especially, the development of immunodeficiency. This causes the development of alimentary anemia, delayed growth and development of piglets, decreased appetite, dyspepsia, gastroenteritis and bronchopneumonia, which brings significant losses to the pig industry. One of the modern directions of research in veterinary practice is the search for environmentally safe preventive means of stimulating nonspecific immunity, mainly of natural origin, and studying their impact on the state of resistance, preservation, growth and productivity of young animals. Among a large number of medicines, the best products are developed on the basis of natural components. Hypericum perforatum has a lot of medical properties. In this regard, we have studied the effect of various doses of the phytopreparation "Deprim", containing an extract of the herb Hypericum perforatum L., on the productivity and safety of piglets and the establishment of its optimal dose in pig farming. This manuscript shows that the use of "Deprim" herbal medicine in piglets in two courses at a dose of 5, 10 and 15 mg / kg of fat contributed to a significant increase in body weight. It was found that after 10 days of giving the herbal medicine, the body weight of animals in the 3 experimental group significantly increased (p<0.01) by 1.06 times, compared to the control group. After 20 days of the experiment, we also observed positive dynamics in the animals only in the piglets of the 3 experimental group – a significant (p<0.05) increase of 1.08 times compared to the control group. It should be noted that in animals of all experimental groups, a month after giving the animals a phytopreparation, its positive effect on the growth of live weight was noted. Thus, 60 day-old piglets of the first, second and third experimental groups had a significant increase in animal body weight of 1.04 (p<0.05); 1.10 (p<0.05) and 1.15 (p<0.001) times, respectively. The prospect of further research is to determine the lymphocytic profile (the content of B-and Tlymphocytes, types of the latter), as well as the level of proinflammatory cytokines in order to establish a more precise mechanism of action of the phytopreparation "Deprim" on the immune system of piglets. © 2020, Advanced Scientific Research. All rights reserved