Improvement of Gut Barrier Function by Potato Anthocyanins Is Dependent on Gut Microbiota

Ulcerative colitis (UC) is characterized by chronic colonic inflammation, impaired barrier function and gut bacterial dysbiosis. Anthocyanin-containing potatoes have been shown to maintain the intestinal barrier function in colitic mice. However, the role of gut microbiota in the anti-colitic effects of anthocyanin- containing potatoes is not clear. This study evaluated the gut barrier protective efficacy of purple- and red-fleshed potatoes using a DSS- induced murine model of colitis with the intact and antibiotic-depleted microbiota

Predator-prey survival pressure is sufficient to evolve swarming behaviors

The comprehension of how local interactions arise in global collective behavior is of utmost importance in both biological and physical research. Traditional agent-based models often rely on static rules that fail to capture the dynamic strategies of the biological world. Reinforcement learning has been proposed as a solution, but most previous methods adopt handcrafted reward functions that implicitly or explicitly encourage the emergence of swarming behaviors. In this study, we propose a minimal predator-prey coevolution framework based on mixed cooperative-competitive multiagent reinforcement learning, and adopt a reward function that is solely based on the fundamental survival pressure, that is, prey receive a reward of $-1$ if caught by predators while predators receive a reward of $+1$. Surprisingly, our analysis of this approach reveals an unexpectedly rich diversity of emergent behaviors for both prey and predators, including flocking and swirling behaviors for prey, as well as dispersion tactics, confusion, and marginal predation phenomena for predators. Overall, our study provides novel insights into the collective behavior of organisms and highlights the potential applications in swarm robotics

Transmission efficiency limit for nonlocal metalenses

The rapidly advancing capabilities in nanophotonic design are enabling complex functionalities limited mainly by physical bounds. The efficiency of transmission is a major consideration, but its ultimate limit remains unknown for most systems. Here, we introduce a matrix formalism that puts a fundamental bound on the channel-averaged transmission efficiency of any passive multi-channel optical system based only on energy conservation and the desired functionality, independent of the interior structure and material composition. Applying this formalism to diffraction-limited nonlocal metalenses with a wide field of view, we show that the transmission efficiency must decrease with the numerical aperture for the commonly adopted designs with equal entrance and output aperture diameters. We also show that reducing the size of the entrance aperture can raise the efficiency bound. This work reveals a fundamental limit on the transmission efficiency as well as providing guidance for the design of high-efficiency multi-channel optical systems

First-principles Study of High-Pressure Phase Stability and Superconductivity of Bi4I4

Bismuth iodide Bi4I4 exhibits intricate crystal structures and topological insulating states that are highly susceptible to influence by environments, making its physical properties highly tunable by external conditions. In this work, we study the evolution of structural and electronic properties of Bi4I4 at high pressure using an advanced structure search method in conjunction with first-principles calculations. Our results indicate that the most stable ambient-pressure monoclinic α−Bi4I4 phase in C2/m symmetry transforms to a trigonal P31c structure (ɛ−Bi4I4) at 8.4 GPa, then to a tetragonal P4/mmm structure (ζ−Bi4I4) above 16.6 GPa. In contrast to the semiconducting nature of ambient-pressure Bi4I4, the two high-pressure phases are metallic, in agreement with reported electrical measurements. The ɛ−Bi4I4 phase exhibits distinct ionic states of Iδ− and (Bi4I3)δ + (δ=0.4123 e), driven by a pressure-induced volume reduction. We show that both ɛ- and ζ−Bi4I4 are superconductors, and the emergence of pressure-induced superconductivity might be intimately linked to the underlying structural phase transitions