Exploring Asymmetric Tunable Blind-Spots for Self-supervised Denoising in Real-World Scenarios

Self-supervised denoising has attracted widespread attention due to its ability to train without clean images. However, noise in real-world scenarios is often spatially correlated, which causes many self-supervised algorithms based on the pixel-wise independent noise assumption to perform poorly on real-world images. Recently, asymmetric pixel-shuffle downsampling (AP) has been proposed to disrupt the spatial correlation of noise. However, downsampling introduces aliasing effects, and the post-processing to eliminate these effects can destroy the spatial structure and high-frequency details of the image, in addition to being time-consuming. In this paper, we systematically analyze downsampling-based methods and propose an Asymmetric Tunable Blind-Spot Network (AT-BSN) to address these issues. We design a blind-spot network with a freely tunable blind-spot size, using a large blind-spot during training to suppress local spatially correlated noise while minimizing damage to the global structure, and a small blind-spot during inference to minimize information loss. Moreover, we propose blind-spot self-ensemble and distillation of non-blind-spot network to further improve performance and reduce computational complexity. Experimental results demonstrate that our method achieves state-of-the-art results while comprehensively outperforming other self-supervised methods in terms of image texture maintaining, parameter count, computation cost, and inference time

Experiments on Longitudinal and Transverse Bedload Transport in Sine-Generated Meandering Channels

Bedload grains in consecutive meandering bends either move longitudinally or across the channel centerline. This study traces and quantifies the grains’ movement in two laboratorial sine-generated channels, i.e., one with deflection angle θ0 = 30◦ and the other 110◦. The grains originally paved along the channels are uniform in size with D = 1 mm and are dyed in various colors, according to their initial location. The experiments recorded the changes in the flow patterns, bed deformation, and the gain-loss distribution of the colored grains in the pool-bar complexes. We observed the formation of two types of erosion zones during the process of the bed deformation, i.e., Zone 1 in the foreside of the point bars and Zone 2 near the concave bank downstream of the bend apexes. Most grains eroded from Zone 1 are observed moving longitudinally as opposed to crossing the channel centerline. Contrastingly, the dominant moving direction of the grains eroded from Zone 2 changes from the longitudinal direction to the transversal one as the bed topography evolves. Besides, most building material of the point bars comes from the upstream bends, although low-and highly curved channels behave differently

A hybrid single-mode laser based on slotted silicon waveguides

An InGaAsP-Si hybrid single-mode laser based on etched slots in silicon waveguides was demonstrated operating at 1543 nm. The InGaAsP gain structure was bonded onto a patterned silicon-on-insulator wafer by selective area metal bonding method. The mode-selection mechanism based on a slotted silicon waveguide was applied, in which the parameters were designed using the simulation tool cavity modeling framework. The III-V lasers employed buried ridge stripe structure. The whole fabrication process only needs standard photolithography and inductively coupled plasma etching technology, which reduces cost for ease in technology transfer. At room temperature, a single mode of 1543-nm wavelength at a threshold current of 21 mA with a maximum output power of 1.9 mW in continuous-wave regime was obtained. The side mode suppression ratio was larger than 35 dB. The simplicity and flexibility of the fabrication process and a low cost make the slotted hybrid laser a promising light source

Active Fragment of Veronica ciliata

Excessive amounts of reactive oxygen species (ROS) in the body are a key factor in the development of hepatopathies such as hepatitis. The aim of this study was to assess the antioxidation effect in vitro and hepatoprotective activity of the active fragment of Veronica ciliata Fisch. (VCAF). Antioxidant assays (DPPH, superoxide, and hydroxyl radicals scavenging) were conducted, and hepatoprotective effects through the application of tert-butyl hydroperoxide- (t-BHP-) induced oxidative stress injury in HepG2 cells were evaluated. VCAF had high phenolic and flavonoid contents and strong antioxidant activity. From the perspective of hepatoprotection, VCAF exhibited a significant protective effect on t-BHP-induced HepG2 cell injury, as indicated by reductions in cytotoxicity and the levels of ROS, 8-hydroxydeoxyguanosine (8-OHdG), and protein carbonyls. Further study demonstrated that VCAF attenuated the apoptosis of t-BHP-treated HepG2 cells by suppressing the activation of caspase-3 and caspase-8. Moreover, it significantly decreased the levels of ALT and AST, increased the activities of acetyl cholinesterase (AChE), glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT), and increased total antioxidative capability (T-AOC). Collectively, we concluded that VCAF may be a considerable candidate for protecting against liver injury owing to its excellent antioxidant and antiapoptosis properties