Role of sintering temperature dependent crystallization of bioactive glasses on erythrocyte and cytocompatibility

Bioglass (BG) was prepared by sol-gel method and the role of sintering temperatures (600, 700 and 800 °C) on crystalline phase changes, bioactivity, erythrocyte and MG-63 cell line compatibility was investigated. Increase in sintering temperature from 600 to 800 °C led to the secondary phase formation that was confirmed through structural analysis. Micrographics revealed the formation of nanorods (700 °C) and nanoflake like (800 °C) morphologies. Biocompatibility assay showed that, BG sintered at 600 °C had optimal biocompatibility while better mechanical property was noted at 700 °C. Altogether, the study demonstrated that increasing the sintering temperature will result in increased crystallinity which in turn resulted in the optimal biomineralization but decreased the biocompatibility. Hence, we demonstrated the importance of temperature during the processing of BG for various applications, as it affects many properties including bioactivity and compatibility