Mitochondrial respiratory states and rate

As the knowledge base and importance of mitochondrial physiology to human health expands, the necessity for harmonizing the terminologyconcerning mitochondrial respiratory states and rates has become increasingly apparent. Thechemiosmotic theoryestablishes the mechanism of energy transformationandcoupling in oxidative phosphorylation. Theunifying concept of the protonmotive force providestheframeworkfordeveloping a consistent theoretical foundation ofmitochondrial physiology and bioenergetics.We followguidelines of the International Union of Pure and Applied Chemistry(IUPAC)onterminology inphysical chemistry, extended by considerationsofopen systems and thermodynamicsof irreversible processes.Theconcept-driven constructive terminology incorporates the meaning of each quantity and alignsconcepts and symbols withthe nomenclature of classicalbioenergetics. We endeavour to provide a balanced view ofmitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes.Uniform standards for evaluation of respiratory states and rates will ultimatelycontribute to reproducibility between laboratories and thussupport the development of databases of mitochondrial respiratory function in species, tissues, and cells.Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

The impact of electrode type on intraoperative and postoperative telemetry measures in cochlear implant using different surgical technique

En Abstract Background Cochlear implantation (CI) is largely considered successful based on the device’s ability to reliably send electrical signals to the auditory nerve fibers. Telemetry (electrode impedance) is a bidirectional communication system. The telemetry system allows us to test the basic functions of a CI and to detect the electrical problems in each electrode. Aim The aims of this study were to monitor electrode telemetry at the intraoperative and initial-activation postoperative periods and to correlate the telemetry measures with the type of inserted electrode and surgical technique. Patients and methods A retrospective analysis of impedance data from 69 CI surgeries occurring at the Hearing and Speech Institute was conducted. Intraoperative and postoperative impedance values were available in 69 pediatric and adult patients during the first fitting 3 weeks to 1 month postoperatively. The data obtained in this study were divided into four groups depending on the type of implanted electrode and device used. In this research, four types of electrodes (Mid Scala, 1J, Flex 28, and Standard) and two surgical techniques (cochleostomy and round window) were used. Results Findings showed that there is a statistically significant difference between intraoperative and postoperative mean average of telemetry measure for 1J and Flex 28 electrodes that increased postoperatively. There was no statistically significant difference between intraoperative and postoperative mean±SD of each of the two electrodes (Mid Scala, 1J, Flex 28, and Standard). Comparison between intraoperative and postoperative average of the four electrodes shows statistically significant difference in intraoperative average. The study also showed that there is no statistical difference between telemetry results when either cochleostomy or round-window approaches were used. Conclusion Findings of this research showed increase in postoperative impedance with all types of electrodes, which can be referred to the absence of electrical stimulation prior to initial activation of the device. There is statistically significant difference in intra-operative telemetry average between four types of used electrode

Resultados de Pesquisa em Nutrição de Aves no Brasil: Resumo dos Ultimos 5 anos Results of Poultry Nutrition Research in Brazil: A Summary of the Last 5 years

Foi realizada uma revisão bibliográfica sobre as pesquisas brasileiras na área de nutrição avícola, entre 1994 a l999. Nesse período, foi publicado um total de 496 trabalhos, com uma média de 82,7 trabalhos/ ano. Os trabalhos na área de nutrição revelaram que 64,52% foram realizados com frangos de corte; 24,19%, com poedoiras e aves de reposição; 3,93%, com matrizes pesadas; e 7,66%, com outras aves. Com relação às publicações em forma de resumos expandidos, foram publicados 226 e 163 resumos, nos Anais das Reuniões Anuais da Fundação APINCO de Ciência e Tecnologia Avícolas e da Sociedade Brasileira de Zootecnia, respectivamente. Na Revista da Sociedade Brasileira de Zootecnia e no Arquivo Brasileiro de Medicina Veterinária e Zootecnia foram publicados, respectivamente, 65 e 34 trabalhos completos. Os pesquisadores das instituições UFV, UNESP-Jaboticabal e UFRGS publicaram no total 104, 92 e 46 trabalhos. As pesquisas concentraram-se principalmente nas áreas de proteína/aminoácidos (21,77%), avaliação de alimentos (21,77%), minerais (19,15%) e aditivos (16,33%).<br>A literature review of the papers published in the area of poultry nutrition was done considering Brazilian publications from the period of 1994 to 1999. During this period a total of 496 papers were published, with an average of 82. 7 papers/year. The publications in nutrition revealed that 64. 52% were made with broiler chickens, 24. 19% with laying hens and replacement birds, 3.93% with broiler breeders and 7.66% with other type of birds. Considering the publications in the form of summary, 226 and 163, were published in the Proceedings of Fundação APINCO de Ciência e Tecnologia Avícola and Sociedade Brasileira de Zootecnia, respectively. In the Revista da Sociedade Brasileira de Zootecnia and Arquivo Brasileiro de Medicina Veterinária e Zootecnia were published, 65 and 34 papers, respectively. Researches in the Universities UFV, UNESP-Jaboticabal and UFRGS, accounted for a total 104, 92 and 46 papers, respectively. The papers in poultry nutrition concentrated mainly in the area of protein/amino acid (21.77%), feedstuffs evaluation (21.77%), minerals (19.15%) and additives (16.33%)