ПРИМЕНЕНИЕ ОБОГАЩЕННОЙ ТРОМБОЦИТАМИ ПЛАЗМЫ В КУПИРОВАНИИ БОЛЕВОГО СИНДРОМА БОЛЬШОГО ВЕРТЕЛА

The results of a comparative study of platelet-rich plasma (PRP) and glucocorticosteroids (GCS) for local treatment of greater trochanteric pain syndrome (GTPS) are presented. 40 patients with GTPS were randomized into groups of 20 persons. The condition of patients was analyzed on a scale of pain during the day (VAS) and index WOMAC. 40 women with GTPS at six months of observation show that the local injections of PRP is superior to therapy with corticosteroids. The data of the study allow to expand the scope of the PRP and the first to recommend this therapy for GTPS. Local PRP therapy is distinguished by the absence of undesirable reactions, and high efficiency in GTPS exceeding the glucocorticosteroids.Представлены результаты сравнительного исследования применения обогащенной тромбоцитами плазмы (ОТП) и глюкокортикостероидов (ГКС) при локальной терапии болевого синдрома большого вертела (БСБВ). Всего обследовано 40 пациенток с БСБВ, которые были рандомизированы в группы по 20 человек. Состояние больных анализировали по шкале боли в течение дня (ВАШ) и индексу WOMAC. У 40 женщин с БСБВ в шестимесячном наблюдении показано, что локальное лечение инъекциями ОТП превосходит по эффективности терапию ГКС. Данные проведенного исследования позволяют расширить область применения ОТП и впервые рекомендовать проведение данного вида терапии при БСБВ. Локальная терапия ОТП отличается отсутствием нежелательных реакций и высокой эффективностью при БСБВ, превосходящей ГКС

Long-term neurological and behavioral results of biodegradable scaffold implantation in mice brain

The aim of the study was to assess the integral outcomes of implantation biocompatible scaffold as the carrier of neural stem cells in the reconstructive surgery of open traumatic brain injury (TBI) by parameters of neurological and cognitive status of the animals in the experiment. Materials and Methods. Adult male C57BL/6 mice were injured with open-skull weight-drop method. 3D hydrogel scaffold based on modified chitosan in complex with hyaluronic acid was transplanted into the lesion cavity 1 week after TBI. Using a variety of behavioral and cognitive tests (modified neurological severity scores (mNSS), open field test as well as novel object recognition and passive avoidance tests) the short-and long-term neurological and memory functions sequelae induced by TBI were assessed. Magnetic resonance imaging was used to visualize the injury site. Results. Significant functional recovery was observed on both the mNSS and open field tests in the scaffold transplantation group compared to the control TBI group. In addition, enhanced improvement of short and long-term memory functions was found 5 months post injury. Magnetic resonance imaging data revealed that the scaffold transplantation result in decreasing of the volume of injury area compared to control TBI group and preventing the disruption of the neural networks of the brain. Conclusion. Taken together, our findings indicated that transplantation of 3D biodegradable scaffold into injury cavity contributed to the preservation of volume in the damaged region in the first months after TBI which in turn led to a better functional recovery in the remote period

Long-term neurological and behavioral results of biodegradable scaffold implantation in mice brain

The aim of the study was to assess the integral outcomes of implantation biocompatible scaffold as the carrier of neural stem cells in the reconstructive surgery of open traumatic brain injury (TBI) by parameters of neurological and cognitive status of the animals in the experiment. Materials and Methods. Adult male C57BL/6 mice were injured with open-skull weight-drop method. 3D hydrogel scaffold based on modified chitosan in complex with hyaluronic acid was transplanted into the lesion cavity 1 week after TBI. Using a variety of behavioral and cognitive tests (modified neurological severity scores (mNSS), open field test as well as novel object recognition and passive avoidance tests) the short-and long-term neurological and memory functions sequelae induced by TBI were assessed. Magnetic resonance imaging was used to visualize the injury site. Results. Significant functional recovery was observed on both the mNSS and open field tests in the scaffold transplantation group compared to the control TBI group. In addition, enhanced improvement of short and long-term memory functions was found 5 months post injury. Magnetic resonance imaging data revealed that the scaffold transplantation result in decreasing of the volume of injury area compared to control TBI group and preventing the disruption of the neural networks of the brain. Conclusion. Taken together, our findings indicated that transplantation of 3D biodegradable scaffold into injury cavity contributed to the preservation of volume in the damaged region in the first months after TBI which in turn led to a better functional recovery in the remote period