170 research outputs found

    Correspondence: Replacement Reserve Funds

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    The Mines of Spain

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    FAQ of Resources and Services for Immigrants in Connecticut

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    New immigrants face many cultural, economic, and language barriers upon arriving in the United States. Due to these barriers, they rely heavily on the services provided to them by governmental agencies and community based organizations. However, many of these services are not advertised to the immigrant population and are difficult to navigate. Further, for undocumented immigrants, many essen.al services are simply not available for them. This research project will develop a comprehensive list of services available to immigrants in Connecticut, with a focus on services for undocumented immigrants, based off of the most common questions that immigrants have asked at The American Place at the Hartford Public Library. This form will be produced through research and conversations with service providers in Connecticut, the public school system, and branches of local government. While researching services at several government agencies and other service providers, it has become clear that some officials and administrators are unaware of the protocols and services for the undocumented population. However, the services available, especially involving public schools and community based organizations, have been identified and recorded and will serve to help Hartford’s immigrant population. The production of this Frequently Asked Questions sheet will serve as a lesson for the public as it will make visible the lack of resources for the undocumented immigrant community and show the need for comprehensive immigration reform in order for all people to receive basic human services

    Depreciation in Public-utility Income Accounts

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    Exploring DACA Recipients\u27 Access to Higher Education in Connecticut

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    Deferred Action for Childhood Arrival (DACA) recipients represent a new and somewhat unexplored population within the undocumented immigrant community. Having only been introduced three years ago, they live within a state of liminality, legally present in the United States for the first time but with the understanding that it can be stripped from them without a moments warning. DACA is an executive order announced by Obama in 2012, which stated that certain DREAMers (young undocumented immigrants who had been brought to the United States by their parents at a young age) would receive temporary relief from deportation, a work permit, and a social security number for a two-year period. These benefits allow immigrant youth to start actively participating in society, open their imaginations of what kind of life they can have, and start planning their futures. For many DACA youth, this has meant finally being able to think about higher education, as they will have a legitimate way to afford college tuition. This thesis explores how a DACA status has affected ‘DACAmented’ youths’ ability to access higher education in Connecticut. While DACA does not include direct policies concerning educational attainment, there is a strong correlation between obtaining DACA status and accessing higher education. Primarily, DACA has increased DREAMers’ access to higher education because it is easier to pay the tuition once obtaining a legal work permit. However, there are several other ways in which DACA has affected access to higher education. These include increased motivation and aspirations of immigrant students, higher availability of private scholarships, improved receptiveness of colleges to immigrant students, and a greater sense of security and belonging. This study provides an in depth analysis of how DACA has influenced access to higher education through interviews with DREAMers, immigration attorneys, non-profit service providers, youth organizers, community college instructors and high school officials

    THE JURY SYSTEM

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    Shared Sanitation Management and the Role of Social Capital: Findings from an Urban Sanitation Intervention in Maputo, Mozambique.

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    Shared sanitation-sanitation facilities shared by multiple households-is increasingly common in rapidly growing urban areas in low-income countries. However, shared sanitation facilities are often poorly maintained, dissuading regular use and potentially increasing disease risk. In a series of focus group discussions and in-depth interviews, we explored the determinants of shared sanitation management within the context of a larger-scale health impact evaluation of an improved, shared sanitation facility in Maputo, Mozambique. We identified a range of formal management practices users developed to maintain shared sanitation facilities, and found that management strategies were associated with perceived latrine quality. However-even within an intervention context-many users reported that there was no formal system for management of sanitation facilities at the compound level. Social capital played a critical role in the success of both formal and informal management strategies, and low social capital was associated with collective action failure. Shared sanitation facilities should consider ways to support social capital within target communities and identify simple, replicable behavior change models that are not dependent on complex social processes

    Differential expression and role of p21cip/waf1 and p27kip1 in TNF-α-induced inhibition of proliferation in human glioma cells

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    <p>Abstract</p> <p>Background</p> <p>The role of TNF-α in affecting the fate of tumors is controversial, while some studies have reported apoptotic or necrotic effects of TNF-α, others provide evidence that endogenous TNF-α promotes growth and development of tumors. Understanding the mechanism(s) of TNF-α mediated growth arrest will be important in unraveling the contribution of tissue associated macrophages in tumor resistance. The aim of this study was to investigate the role of Cyclin Dependent Kinase Inhibitors (CDKI) – p21<sup>cip/waf1 </sup>and p27<sup>kip1 </sup>in TNF-α mediated responses in context with p53 and activation of NF-κB and Akt pathways. The study was done with human glioma cell lines -LN-18 and LN-229 cells, using monolayer cultures and Multicellular Spheroids (MCS) as <it>in vitro </it>models.</p> <p>Results</p> <p>TNF-α induced inhibition of proliferation and enhanced the expression of p21<sup>cip/waf1 </sup>and p27<sup>kip1 </sup>in LN-18 cells. p21 was induced on exposure to TNF-α, localized exclusively in the nucleus and functioned as an inhibitor of cell cycle but not as an antiapoptotic protein. In contrast, p27 was constitutively expressed, localized predominantly in the cytoplasm and was not involved in arrest of proliferation. Our data using IκBα mutant LN-18 cells and PI3K/Akt inhibitor-LY294002 revealed that the expression of p21 is regulated by NF-κB. Loss of IκBα function in LN-229 cells (p53 positive) did not influence TNF-α induced accumulation of pp53 (Ser-20 p53) suggesting that p53 was not down stream of NF-κB. Spheroidogenesis enhanced p27 expression and p21 induced by TNF-α was significantly increased in the MCS compared to monolayers.</p> <p>Conclusion</p> <p>This study demarcates the functional roles for CDKIs-p21<sup>cip/waf1 </sup>and p27<sup>kip1 </sup>during TNF-α stimulated responses in LN-18 glioma cells. Our findings provide evidence that TNF-α-induced p21 might be regulated by NF-κB or p53 independently. p21 functions as an inhibitor of cell proliferation and does not have a direct role in rendering the cells resistant to TNF-α mediated cytotoxicity.</p

    Shared latrines in Maputo, Mozambique: exploring emotional well-being and psychosocial stress.

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    BACKGROUND: Approximately 18% of Sub-Saharan Africa's urban population relies on shared sanitation facilities, which are shared by one or more households. While there is growing recognition of sanitation's relationship with stress and well-being - particularly among women - most research has focused on rural populations and the transition from open defecation and/or unimproved latrines to private shared sanitation. This study explores sanitation-related stressors among users of both improved and unimproved shared sanitation facilities. METHODS: This study was nested within the larger MapSan health impact trial (Trial Registration: NCT02362932). Participants were recruited from the control arm of the trial (Traditional Latrine (TL) users) and intervention arm, which received one of two improved shared sanitation facilities - Shared Latrines (SL) shared by up to 20 individuals and Community Sanitation Blocks (CSBs) shared by more than 20 individuals. Sampling was informed by a life stage perspective to reflect diversity in sanitation needs and experiences within the population. Data included 96 in-depth interviews, 7 focus group discussions, and 25 unstructured observations. Data collection and analysis followed a Grounded Theory approach, which was used to identify the key domains of sanitation-related stress among participants. A semi-structured tool was applied to all female interview transcripts to assess the frequency and severity of key stressors. RESULTS: Participants reported stress due to: lack of safety; lack of privacy; disgust about the latrine condition; and collective action failure in terms of managing the latrine, often causing neighborhood conflict or unhygienic sanitation conditions. Fewer SL and CSB users reported specific stress domains and - with the exception of perceived safety - reported fewer severe stressors. The leading cause of stress reduction due to the intervention was decreased disgust followed by increased privacy and safety. CONCLUSIONS: Our data suggest that "improved", shared facilities can reduce stress when proper maintenance and management systems are in place. Private, shared sanitation only had limited impact on users' perceptions of safety, particularly at night, suggesting that safety concerns extend beyond the physical latrine structure. Our research demonstrates that factors including latrine location and neighborhood violence are important determinants of safety perceptions and corresponding psychosocial stress

    МОДЕЛИ И РЕАЛИЗАЦИЯ ОБНАРУЖЕНИЯ ВТОРЖЕНИЙ В КОРПОРАТИВНОЙ ИНФОРМАЦИОННОЙ СИСТЕМЕ ПРЕДПРИЯТИЯ С ИСПОЛЬЗОВАНИЕМ ИНТЕЛЛЕКТУАЛЬНОГО ПОДХОДА

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    The methodic of intrusion detection in corporate information systems (CIS) on three levels are done. Models of autonomic and net intrusion detection systems (IDS) including some components are presented. IDS on the base of Snort is worked out and used. During its investigation some tasks were executed: creating the virtual computer net for CIS, analyzing its possible vulnerability; attuning and preparing IDS for CIS with intellectual approach (knowledge in rules view); checking of IDS activity during simulation various attacks and their detection.Приведена методика обнаружения вторжений в корпоративной информационной системе (КИС) по трем уровням. Представлены модели автономной и сетевой систем обнаружения вторжений (СОВ), включающие ряд компонент. Разработана и внедрена СОВ на базе инструментария Snort. В ходе исследований были выполнены задачи: построена виртуальная компьютерная сеть КИС; проанализированы возможные ее уязвимости; настроена и подготовлена к работе СОВ для КИС с использованием интеллектуального подхода (знания в виде правил); произведена проверка работоспособности СОВ путем моделирования различных атак и их обнаружения
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