Bubble evolution in the titanium alloy melt under vertical centrifugal field

The bubble evolution in the liquid titanium melt under vertical centrifugal field has been studied by the hydraulic experiment simulation. The bubble migration process in the simple and complex cavities, the bubble morphology, bubble dimensional size diversification under different mould rotational speed has been investigated. The results show that the mould wall has a blocking effect on the bubble migration. The bubble migration in the simple cavity deviates from the line between the bubble initial position and the rotation shaft of the casting mould. Also, the bubbles in the complex cavity gather, re-nucleate and form new big ones for the blocking effect of the complex geometry shape on the radial movement of the bubble. The shape of bubbles in both the simple and complex cavity during the migration process is not a perfect sphere, but an elliptical shape. The critical size of bubble released from the bubble generation chamber decreases with the increment of the mould rotational speed. The diameter of the gas bubbles in the simple cavity during the migration process become bigger and bigger for the pressure difference at different positions of the cavity in the vertical centrifugal field

G-CSF mobilized PBMCs contribute to the liver function of cirrhotic rats

On the basis of the recently recognized potential of bone marrow stem cells to give rise to hepatocytes, we here investigated the role of G-CSF priming PBMCs played in the liver of cirrhotic rats. The animal model of liver cirrhosis was induced by injecting CCl4 in SD rats, and G-CSF was administered in hematopoietic stem cell mobilization doses. After the liver cirrhosis model was established, the female cirrhotic rats were divided into two groups. Group I only received G-CSF mobilization, group II received G-CSF mobilized PBMCs transplanted from the male cirrhotic rats. PKH26 staining and sex-determining region for the Y-chromosome gene were used to trace the transplanted cells. Liver function related factors were assayed under the animal automatic biochemistry analyzer, and the liver pathological changes were evaluated by HE staining. The comparative liver functions of the two groups were investigated by analysis of two sample t-tests. A P value of <0.05 was considered as significant in all analyses. Our results showed that the transplanted PBMCs could locate in the livers of the female rats. In addition, compared with the group I, rats in group II displayed significant liver improvement in serum ALB, ALT, AST and TBIL (p<0.05). However, the semi-quantitative classification of the liver pathological changes in both groups did not indicate a significant difference (p>0.05). The results indicated that mobilized PBMC transplant could contribute to liver function in cirrhotic livers, which might be an alternative therapy for liver cirrhosis

Leveraging Architectural Approaches in Web3 Applications -- A DAO Perspective Focused

Architectural design contexts contain a set of factors that influence software application development. Among them, \textit{\textbf{organizational}} design contexts consist of high-level company concerns and how it is structured, for example, stakeholders and development schedule, heavily impacting design considerations. Decentralized Autonomous Organization (DAO), as a vital concept in the Web3 space, is an organization constructed by automatically executed rules such as via smart contracts, holding features of the permissionless committee, transparent proposals, and fair contribution by stakeholders. In this work, we conduct a systematic literature review to summarize how DAO is structured as well as explore its benefits\&challenges in Web3 applications

Galactic diffuse gamma-ray emission from GeV to PeV energies in light of up-to-date cosmic ray measurements

The diffuse gamma-ray emission between 10 and 1000 TeV from the Galactic plane was recently measured by the Large High Altitude Air Shower Observatory (LHAASO). These observations will help tremendously in constraining the propagation and interaction of cosmic rays in the Milky Way. Additionally, new measurements of CR spectra reach a very high precision up to 100 TeV energies, revealing multiple spectral structures of various species. In this work, we confront the model prediction of the diffuse gamma-ray emission, based on up-to-date measurements of the local cosmic ray spectra and simplified propagation setup, with the measurements of diffuse gamma-rays. To better constrain the low-energy part of the model, we analyze the 14.6 years of Fermi-LAT data to extract the Galactic diffuse emission between 1 and 500 GeV from the same sky regions of LHAASO, after subtracting the contribution from known sources and the isotropic diffuse gamma-ray background. The joint Fermi-LAT and LHAASO spectra thus cover a very wide energy range from 1 GeV to 1 PeV with small gaps from 0.5 to 10 TeV. Compared with the prediction, we find that clear excesses between several GeV and ~60 TeV of the diffuse emission exist. Possible reasons to explain the excesses may include unresolved sources or more complicated propagation models. We illustrate that an exponential-cutoff-power-law component with an index of -2.40 and cutoff energy of ~30 TeV is able to account for such excesses

Mold filling behavior of titanium melt in thin-walled and complicated cavities in hypergravity field

The mold filling process of titanium alloy in the thin-walled and complicated cavities in hypergravity field is the subject of this paper. The obtained results indicate that the filling process of the melt in the thin-walled and complicated cavity at different mould rotational speeds is quite complex. The free surface of the melt in the thin-walled ribs moves forward in a near planar way parallel to the gravity direction under different mould rotational speeds. The mold filling process with higher filling rotational speed, 300rpm and 500rpm shows that the free surface in the thin-walled ribs and backward filling in the radial runners are in the same vertical plane. Besides, the speed of backward filling in the radial runner is equal to that in the thin-walled ribs. The free surface during the backward filling process at the rotational speeds of 300rpm and 500rpm is a series of arc surfaces, while the free surface during backward filling with 150rpm is not obvious, for the free surface during the forward filling process occupies nearly the whole radial runner