342 research outputs found
Fast Approximate -Means via Cluster Closures
-means, a simple and effective clustering algorithm, is one of the most
widely used algorithms in multimedia and computer vision community. Traditional
-means is an iterative algorithm---in each iteration new cluster centers are
computed and each data point is re-assigned to its nearest center. The cluster
re-assignment step becomes prohibitively expensive when the number of data
points and cluster centers are large.
In this paper, we propose a novel approximate -means algorithm to greatly
reduce the computational complexity in the assignment step. Our approach is
motivated by the observation that most active points changing their cluster
assignments at each iteration are located on or near cluster boundaries. The
idea is to efficiently identify those active points by pre-assembling the data
into groups of neighboring points using multiple random spatial partition
trees, and to use the neighborhood information to construct a closure for each
cluster, in such a way only a small number of cluster candidates need to be
considered when assigning a data point to its nearest cluster. Using complexity
analysis, image data clustering, and applications to image retrieval, we show
that our approach out-performs state-of-the-art approximate -means
algorithms in terms of clustering quality and efficiency
Optimized Cartesian -Means
Product quantization-based approaches are effective to encode
high-dimensional data points for approximate nearest neighbor search. The space
is decomposed into a Cartesian product of low-dimensional subspaces, each of
which generates a sub codebook. Data points are encoded as compact binary codes
using these sub codebooks, and the distance between two data points can be
approximated efficiently from their codes by the precomputed lookup tables.
Traditionally, to encode a subvector of a data point in a subspace, only one
sub codeword in the corresponding sub codebook is selected, which may impose
strict restrictions on the search accuracy. In this paper, we propose a novel
approach, named Optimized Cartesian -Means (OCKM), to better encode the data
points for more accurate approximate nearest neighbor search. In OCKM, multiple
sub codewords are used to encode the subvector of a data point in a subspace.
Each sub codeword stems from different sub codebooks in each subspace, which
are optimally generated with regards to the minimization of the distortion
errors. The high-dimensional data point is then encoded as the concatenation of
the indices of multiple sub codewords from all the subspaces. This can provide
more flexibility and lower distortion errors than traditional methods.
Experimental results on the standard real-life datasets demonstrate the
superiority over state-of-the-art approaches for approximate nearest neighbor
search.Comment: to appear in IEEE TKDE, accepted in Apr. 201
The Combined Signatures of Hypoxia and Cellular Landscape Provides a Prognostic and Therapeutic Biomarker in HBV-Related Hepatocellular Carcinoma
Prognosis and treatment options of HBV-related hepatocellular carcinoma (HBV-HCC) are generally based on tumor burden and liver function. Yet, tumor growth and therapeutic resistance of HBV-HCC are strongly influenced by intratumoral hypoxia and cells infiltrating the tumor microenvironment (TME). We, therefore, studied whether linking parameters associated with hypoxia and TME cells could have a better prediction of prognosis and therapeutic responses. Quantification of 109 hypoxia-related genes and 64 TME cells was performed in 452 HBV-HCC tumors. Prognostic hypoxia and TME cells signatures were determined based on Cox regression and meta-analysis for generating the Hypoxia-TME classifier. Thereafter, the prognosis, tumor, and immune characteristics as well as the benefit of therapies in Hypoxia-TME defined subgroups were analyzed. Patients in the Hypoxialow /TMEhigh subgroup showed a better prognosis and therapeutic responses than any other subgroups, which can be well elucidated based on the differences in terms of immune-related molecules, tumor somatic mutations, and cancer cellular signaling pathways. Notably, our analysis furthermore demonstrated the synergistic influence of hypoxia and TME on tumor metabolism and proliferation. Besides, the classifier allowed a further subdivision of patients with early- and late-HCC stages. In addition, the Hypoxia-TME classifier was validated in another independent HBV-HCC cohort (n=144) and several pan-cancer cohorts. Overall, the Hypoxia-TME classifier showed a pretreatment predictive value for prognosis and therapeutic responses, which might provide new directions for strategizing patients with optimal therapies. This article is protected by copyright. All rights reserved
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