PERSISTENT ORGANOCHLORINE RESIDUES IN HUMAN BREAST MILK FROM VIETNAM : CONTAMINATION, ACCUMULATION KINETICS AND RISK ASSESSMENT

Joint Research on Environmental Science and Technology for the Eart

IgG-class anti-PF4/heparin antibodies and symptomatic DVT in orthopedic surgery patients receiving different anti-thromboembolic prophylaxis therapeutics

<p>Abstract</p> <p>Background</p> <p>Heparin-induced thrombocytopenia (HIT) is a thromboembolic complication that can occur with unfractionated heparin (UFH) or low molecular weight heparin (LMWH). Our objective was to determine and compare the incidence of IgG-class HIT antibodies in patients undergoing total hip arthroplasty (THA) or total knee arthroplasty (TKA) with different antithrombotic prophylaxis therapies and their contributions to the occurrence of venous thromboembolism (VTE).</p> <p>Methods</p> <p>A prospective observational study was performed for 374 Japanese patients undergoing THA or TKA to determine the incidence of VTE. IgG-class anti-PF4/heparin antibodies were measured using IgG-specific EIA before and after the operation.</p> <p>Results</p> <p>In the clinical outcome, the incidence of symptomatic deep vein thrombosis (DVT) was 15.0% (56/374, TKA; 35, THA; 21) and pulmonary emboli (PE) were not observed. The total seroconversion incidence of IgG-class PF4/heparin antibodies was 19.8% (74/374). The seroconversion incidence of IgG-class PF4/heparin antibodies was higher in patients receiving UFH (32.7%) compared to those receiving LMWH (9.5%) or fondaparinux (14.8%). Furthermore, the seroconversion incidence was significantly higher in patients undergoing TKA compared to those undergoing THA. Based on multivariate analysis, seroconversion of the IgG-class PF4/heparin antibodies was independent a risk factor for symptomatic DVT.</p> <p>Conclusion</p> <p>Our findings show that the seroconversion of IgG-class anti-PF4/heparin antibodies differed with various anti-thrombotic prophylaxis therapeutics and was associated with the risk of DVT in a subset of patients undergoing total joint arthroplasty (TKA and THA).</p

Identification of major dioxin-like compounds and androgen receptor antagonist in acid-treated tissue extracts of high trophic-level animals

We evaluated the applicability of combining in vitro bioassays with instrument analyses to identify potential endocrine disrupting pollutants in sulfuric acid-treated extracts of liver and/or blubber of high trophic-level animals. Dioxin-like and androgen receptor (AR) antagonistic activities were observed in Baikal seals, common cormorants, raccoon dogs, and finless porpoises by using a panel of rat and human cell-based chemical-activated luciferase gene expression (CALUX) reporter gene bioassays. On the other hand, no activity was detected in estrogen receptor α (ERα)-, glucocorticoid receptor (GR)-, progesterone receptor (PR)-, and peroxisome proliferator-activated receptor γ2 (PPARγ2)-CALUX assays with the sample amount applied. All individual samples (n = 66) showed dioxin-like activity, with values ranging from 21 to 5500 pg CALUX-2,3,7,8-tetrachlorodibenzo-p-dioxin equivalent (TEQ)/g-lipid. Because dioxins are expected to be strong contributors to CALUX-TEQs, the median theoretical contribution of dioxins calculated from the result of chemical analysis to the experimental CALUX-TEQs was estimated to explain up to 130% for all the tested samples (n = 54). Baikal seal extracts (n = 31), but not other extracts, induced AR antagonistic activities that were 8-150 μg CALUX-flutamide equivalent (FluEQ)/g-lipid. p,p′-DDE was identified as an important causative compound for the activity, and its median theoretical contribution to the experimental CALUX-FluEQs was 59% for the tested Baikal seal tissues (n = 25). Our results demonstrate that combining in vitro CALUX assays with instrument analysis is useful for identifying persistent organic pollutant-like compounds in the tissue of wild animals on the basis of in vitro endocrine disruption toxicity. © 2011 American Chemical Society

Effect of dragged magnetic field lines into RAFM steel blanket modules on first wall heat load

The blanket modules in DEMO are made of reduced-activation ferritic martensitic (RAFM) steel F82H. This material is ferromagnetic and it drags the magnetic field lines into the first wall (FW). Because of this, the heat load by the plasma heat flux, which goes along the magnetic field line will become higher. In this research, the first analysis of such effect has been done. The extra magnetic field Bm made by RAFM wall becomes higher at inner midplane, and the heat load at the module front surface becomes 1.3 MW/m2 to 5 MW/m2. Additionally, near the toroidal gaps, BM becomes high. Thus, at the top of the FW, magnetic field lines are dragged into the toroidal gaps directly because, the magnetic flux surface is not closed. This makes high (about 10MW/m2) heat load concentration at the moduel edge. The effect of the NBI port is also analyzed. Also near the port, Bm becomes high and the orbit of the magnetic field lines are changed. The effect of this doesn\u27t occur near the port, but far region such as inner midplane or top of the FW. The heat load becomes 6 MW/m2 at inner midplane. These results indicate that the effect of RAFM steel on the FW heat load is not negligible, and more detailed analysis is necessary

Effect of dragged magnetic field lines into RAFM steel blanket modules on first wall heat load

The blanket modules in DEMO are made of reduced-activation ferritic martensitic (RAFM) steel F82H. This material is ferromagnetic and it drags the magnetic field lines into the FW. Because of this, the heat load by the plasma heat flux, which goes along the magnetic field line will become higher. In this research, the effect of this is analyzed. The extra magnetic field Bm made by RAFM wall becomes higher at inner midplane, and the heat load at the module front surface becomes 1.3 MW/m2 to 5 MW/m2. Additionally, near the toroidal gaps, BM becomes high. Thus, at the top of the FW, magnetic field lines are dragged into the toroidal gaps directly because, the magnetic flux surface is not closed. This makes high (about 10 MW/m2) heat load concentration at the moduel edge. The effect of the NBI port is also analyzed. Also near the port, Bm becomes high and the orbit of the magnetic field lines are changed. The effect of this doesn\u27t occur near the port, but far region such as inner midplane or top of the FW. The heat load becomes 6 MW/m2 at inner midplane.14th International Symposium on Fusion Nuclear Technolog