Child poverty as a determinant of life outcomes:Evidence from nationwide surveys in Japan

We attempt to examine the extent to which poverty in childhood adversely affects success in adulthood, using micro data from nationwide surveys in Japan and taking into account the recursive structure of life outcomes. We use retrospective assessments of income class at the age of 15, because longitudinal data on household income are not available. After controlling for its endogeneity, we confirm that children from poor families tend to have lower educational attainment, face higher poverty risks, and assess themselves as being less happy and as suffering from poorer health.Child poverty; Educational attainment; Poverty risk; Happiness; Self-rated health

Child poverty as a determinant of life outcomes: Evidence from nationwide surveys in Japan

We attempt to examine the extent to which poverty in childhood adversely affects success in adulthood, using micro data from nationwide surveys in Japan and taking into account the recursive structure of life outcomes. We use retrospective assessments of income class at the age of 15, because longitudinal data on household income are not available. After controlling for its endogeneity, we confirm that children from poor families tend to have lower educational attainment, face higher poverty risks, and assess themselves as being less happy and as suffering from poorer health.Child poverty, Educational attainment, Poverty risk, Happiness, Self-rated health

Revisiting the Effect of Branch Handling Strategies on Change Recommendation

Although literature has noted the effects of branch handling strategies on change recommendation based on evolutionary coupling, they have been tested in a limited experimental setting. Additionally, the branches characteristics that lead to these effects have not been investigated. In this study, we revisited the investigation conducted by Kovalenko et al. on the effect to change recommendation using two different branch handling strategies: including changesets from commits on a branch and excluding them. In addition to the setting by Kovalenko et al., we introduced another setting to compare: extracting a changeset for a branch from a merge commit at once. We compared the change recommendation results and the similarity of the extracted co-changes to those in the future obtained using two strategies through 30 open-source software systems. The results show that handling commits on a branch separately is often more appropriate in change recommendation, although the comparison in an additional setting resulted in a balanced performance among the branch handling strategies. Additionally, we found that the merge commit size and the branch length positively influence the change recommendation results.Comment: 11 pages, ICPC 202

Excited D-branes and Supergravity Solutions

We investigate the general solution with the symmetry ISO(1,p)xSO(9-p) of Type II supergravity (the three-parameter solution) from the viewpoint of the superstring theory. We find that one of the three parameters (c_1) is closely related to the ``dilaton charge'' and the appearance of the dilaton charge is a consequence of deformations of the boundary condition from that of the boundary state for BPS D-branes. We give three examples of the deformed D-branes by considering the tachyon condensation from systems of D-\bar{D}p-branes, unstable D9-branes and unstable D-instantons to the BPS saturated Dp-branes, respectively. We argue that the deformed systems are generally regarded as tachyonic and/or massive excitations of the open strings on Dp-\bar{D}p-brane systems.Comment: 29 pages, 6 figures, LaTeX2e, typos corrected, references adde

gamma 375W fibrinogen-synthesizing CHO cells indicate the accumulation of variant fibrinogen within endoplasmic reticulum

Background: Hepatic endoplasmic reticulum (ER) storage disease (HERSD) associated with hypofibrinogenemia has been reported in patients with four types of heterozygous gamma-chain variant fibrinogen in the C terminal region. Of interest, substitution of gamma R375W induced hypofibrinogenemia and HERSD, whereas gamma R375G induced dysfibrinogenemia. Objectives: To analyze the synthesis of variant fibrinogen and morphological characteristics, we established variant fibrinogen-producing cells and compared them with wild-type fibrinogen-synthesizing cells. Methods: The fibrinogen gamma-chain expression vectors coding gamma 375W and gamma 375G were altered by oligonucleotide-directed mutagenesis and transfected into Chinese hamster ovary (CHO) cells. Synthesis of fibrinogen (media and cell lysates) was measured by ELISA for each cloned cell line and morphological characteristics were observed by immunofluorescence and transmission electron microscopy. Results: The medium/cell lysate fibrinogen ratio of gamma 375W-CHO cells was markedly lower than that of the normal cells and gamma 375G-CHO cells. Immunostaining with anti-fibrinogen antibody showed only gamma 375W-CHO cells, but revealed two types of cells containing cytoplasmic inclusion bodies, scattered large-granular bodies and fibrous forms. Observation by confocal microscopy indicated that both inclusion bodies were colocalized with fibrinogen and ER-membrane protein; furthermore, transmission electron microscopic observation demonstrated dilatation of the ER by large-granular inclusion bodies and fibrous forms filled with regularly structured fibular materials within the dilated ER. Conclusion: These results demonstrated that assembled and non-secreted gamma 375W fibrinogen was accumulated in the dilated ER and aggregated variant fibrinogen was seen as regularly structured fibular materials, which was similar to the fingerprint-like pattern observed at inclusion bodies in patients' hepatocytes affected with HERSD.ArticleTHROMBOSIS RESEARCH. 133(1):101-107 (2014)journal articl

Recombinant gamma T305A fibrinogen indicates severely impaired fibrin polymerization due to the aberrant function of hole 'a' and calcium binding sites

Introduction: We examined a 6-month-old girl with inherited fibrinogen abnormality and no history of bleeding or thrombosis. Routine coagulation screening tests showed a markedly low level of plasma fibrinogen determined by functional measurement and also a low level by antigenic measurement (functional/antigenic ratio = 0.295), suggesting hypodysfibrinogenemia. Materials and methods: DNA sequence analysis was performed, and gamma T305A fibrinogen was synthesized in Chinese hamster ovary cells based on the results. We then functionally analyzed and compared with that of nearby recombinant gamma N308K fibrinogen. Results: DNA sequence analysis revealed a heterozygous gamma T305A substitution (mature protein residue number). The gamma T305A fibrinogen indicated markedly impaired thrombin-catalyzed fibrin polymerization both in the presence or absence of 1 mM calcium ion compared with that of gamma N308K fibrinogen. Protection of plasmin degradation in the presence of calcium ion or Gly-Pro-Arg-Pro peptide (analogue for so-called knob 'A') and factor XIIIa-catalyzed fibrinogen crosslinking demonstrated that the calcium binding sites, hole 'a' and D:D interaction sites were all markedly impaired, whereas gamma N308K was impaired at the latter two sites. Molecular modeling demonstrated that gamma T305 is localized at a shorter distance than gamma N308 from the high affinity calcium binding site and hole 'a'. Conclusion: Our findings suggest that gamma T305 might be important for construction of the overall structure of the. module of fibrinogen. Substitution of gamma T305A leads to both dysfibrinogenemic and hypofibrinogenemic characterization, namely hypodysfibrinogenemia. We have already reported that recombinant gamma T305A fibrinogen was synthesized normally and secreted slightly, but was significantly reduced.ArticleTHROMBOSIS RESEARCH. 134(2):518-525 (2014)journal articl

Open String Tachyon in Supergravity Solution

We study the tachyon condensation of the D-\bar{D}-brane system with a constant tachyon vev in the context of classical solutions of the Type II supergravity. We find that the general solution with the symmetry ISO(1,p)xSO(9-p) (the three-parameter solution) includes the extremal black p-brane solution as an appropriate limit of the solution with fixing one of the three parameters (c_1). Furthermore, we compare the long distance behavior of the solution with the massless modes of the closed strings from the boundary state of the D-\bar{D}-brane system with a constant tachyon vev. We find that we must fix c_1 to zero and the only two parameters are needed to express the tachyon condensation of the D\={D}-brane system. This means that the parameter $c_1$ does not correspond to the tachyon vev of the D\={D}-brane system.Comment: 20 pages, no figures, LaTeX2e, typos corrected, references added and more general result presente