Traditional Chinese Medicine Improves Activities of Daily Living in Parkinson's Disease

We evaluated the effects of a traditional Chinese medicine (TCM), named Zeng-xiao An-shen Zhi-chan 2 (ZAZ2), on patients with Parkinson's disease (PD). Among 115 patients with idiopathic PD enrolled (mean age, 64.7 ± 10.2 years old), 110 patients (M = 65, F = 45; mean age, 64.9 ± 10.7 years old) completed the study. Patients took either ZAZ2 (n = 59) or placebo granule (n = 56) in a blind manner for 13 weeks while maintaining other anti-Parkinson medications unchanged. All participants wore a motion logger, and we analyzed the power-law temporal autocorrelation of the motion logger records taken on 3 occasions (before, one week, and 13 weeks after the drug administration). Drug efficacy was evaluated with the conventional Unified Parkinson Disease Rating Scale (UPDRS), as well as the power-law exponent α, which corresponds to the level of physical activity of the patients. ZAZ2 but not placebo granule improved the awake-sleep rhythm, the UPDRS Part II, Part II + III, and Part IV scores, and the α values. The results indicate that ZAZ2 improved activities of daily living (ADL) of parkinsonism and, thus, is a potentially suitable drug for long-term use

Towards Equitable Representation in Text-to-Image Synthesis Models with the Cross-Cultural Understanding Benchmark (CCUB) Dataset

It has been shown that accurate representation in media improves the well-being of the people who consume it. By contrast, inaccurate representations can negatively affect viewers and lead to harmful perceptions of other cultures. To achieve inclusive representation in generated images, we propose a culturally-aware priming approach for text-to-image synthesis using a small but culturally curated dataset that we collected, known here as Cross-Cultural Understanding Benchmark (CCUB) Dataset, to fight the bias prevalent in giant datasets. Our proposed approach is comprised of two fine-tuning techniques: (1) Adding visual context via fine-tuning a pre-trained text-to-image synthesis model, Stable Diffusion, on the CCUB text-image pairs, and (2) Adding semantic context via automated prompt engineering using the fine-tuned large language model, GPT-3, trained on our CCUB culturally-aware text data. CCUB dataset is curated and our approach is evaluated by people who have a personal relationship with that particular culture. Our experiments indicate that priming using both text and image is effective in improving the cultural relevance and decreasing the offensiveness of generated images while maintaining quality.Comment: Still on going wor

Discovery of four gravitational lensing systems by clusters in the SDSS DR6

We report the discovery of 4 strong gravitational lensing systems by visual inspections of the Sloan Digital Sky Survey images of galaxy clusters in Data Release 6 (SDSS DR6). Two of the four systems show Einstein rings while the others show tangential giant arcs. These arcs or rings have large angular separations (>8") from the bright central galaxies and show bluer color compared with the red cluster galaxies. In addition, we found 5 probable and 4 possible lenses by galaxy clusters.Comment: 6 pages, 3 figures. Added referenc

High-Dialysate-Glucose-Induced Oxidative Stress and Mitochondrial-Mediated Apoptosis in Human Peritoneal Mesothelial Cells

Human peritoneal mesothelial cells (HPMCs) are a critical component of the peritoneal membrane and play a pivotal role in dialysis adequacy. Loss of HPMCs can contribute to complications in peritoneal dialysis. Compelling evidence has shown that high-dialysate glucose is a key factor causing functional changes and cell death in HPMCs. We investigated the mechanism of HPMC apoptosis induced by high-dialysate glucose, particularly the role of mitochondria in the maintenance of HPMCs. HPMCs were incubated at glucose concentrations of 5 mM, 84 mM, 138 mM, and 236 mM. Additionally, N-acetylcysteine (NAC) was used as an antioxidant to clarify the mechanism of high-dialysate-glucose-induced apoptosis. Exposing HPMCs to high-dialysate glucose resulted in substantial apoptosis with cytochrome c release, followed by caspase activation and poly(ADP-ribose) polymerase cleavage. High-dialysate glucose induced excessive reactive oxygen species production and lipid peroxidation as well as oxidative damage to DNA. Mitochondrial fragmentation, multiple mitochondrial DNA deletions, and dissipation of the mitochondrial membrane potential were also observed. The mitochondrial dysfunction and cell death were suppressed using NAC. These results indicated that mitochondrial dysfunction is one of the main causes of high-dialysate-glucose-induced HPMC apoptosis

Low Radon Concentration Measurement with a Radon-Dissolved Liquid Scintillator Pilot Detector

We construct a high sensitivity radon pilot detector using liquid scientillator dissolved radon for the CDEX rare-event searches program. The CDEX-10 project employs a germanium detector array immersed in a massive liquid nitrogen tank. However, radon emanated from the surface of the tank can contribute background. As a result, radon contamination in the liquid nitrogen tank must be regulated and monitored, which necessitates the use of a low-level Rn measuring device. The radon-dissolved liquid scintillator (LS) detectors utilizes cascade decay selections, yielding a unique signature. All background events occurring in the LS, with regard to the system and co-efficiency of Rn absorption, have been studied. Background activity is mearsured to be 59.8$\pm$18.4 $\mu$Bq per 300 mL LS. Meanwhile, it shows that radon concentration absorbed by LS will be saturated and is linearly related to radon concentration in nitrogen gas. Furthermore, the co-efficiency factor can be optimized by lowering temperature or raising pressure. Eventually the detection limit for 222Rn in nitrogen gas is observed to be 9.6 mBq/m^3.Comment: 14 pages, 18 figure

Immunohistochemical localization of galectin-3 in the granulomatous lesions of paratuberculosis-infected bovine intestine

The presence of galectin-3 was immunohistochemically quantified in bovine intestines infected with paratuberculosis (Johne's disease) to determine whether galectin-3 was involved in the formation of granulation tissue associated with the disease. Mycobacterium avium subsp. paratuberculosis infection was histochemically confirmed using Ziehl-Neelsen staining and molecularly diagnosed through rpoB DNA sequencing. Galectin-3 was detected in the majority of inflammatory cells, possibly macrophages, in the granulomatous lesions within affected tissues, including the ileum. These findings suggest that galectin-3 is associated with the formation of chronic granulation tissues in bovine paratuberculosis, probably through cell adhesion and anti-apoptosis mechanisms

Cornelia de Lange Syndrome with NIPBL Gene Mutation: A Case Report

Cornelia de Lange Syndrome (CdLS) is a multiple congenital anomaly characterized by distinctive facial features, upper limb malformations, growth and cognitive retardation. The diagnosis of the syndrome is based on the distinctive clinical features. The etiology is still not clear. Mutations in the sister chromatid cohesion factor genes NIPBL, SMC1A (also called SMC1L1) and SMC3 have been suggested as probable cause of this syndrome. We experienced a case of newborn with CdLS showing bushy eyebrows and synophrys, long curly eyelashes, long philtrum, downturned angles of the mouth and thin upper lips, cleft palate, micrognathia, excessive body hair, micromelia of both hands, flexion contracture of elbows and hypertonicity. We detected a NIPBL gene mutation in a present neonate with CdLS, the first report in Korea

Device-independent verification of Einstein-Podolsky-Rosen steering

If the presence of entanglement could be certified in a device-independent (DI) way, it is likely to provide various quantum information processing tasks with unconditional security. Recently, it was shown that a DI protocol, combining measurement-device-independent techniques with self-testing, is able to verify all entangled states, however, it imposes demanding requirements on its practical implementation. Here, we present a less-demanding protocol based on Einstein-Podolsky-Rosen (EPR) steering, which is achievable with current technology. Particularly, we first establish a complete framework for DI verification of EPR steering and show that all steerable states can be verified. Then, we analyze the three-measurement setting case, allowing for imperfections of self-testing. Finally, a four-photon experiment is implemented to device-independently verify EPR steering and to further demonstrate that even Bell local states can be faithfully verified. Our findings pave the way for realistic applications of secure quantum information tasksComment: 6+8 pages; Comments are welcom