Rheological method for alpha test evaluation of developing superplasticizers' performance: Channel flow test

Advance in high-range water-reducing admixture revolutionizes the workability and constructability of conventional vibrated concrete as well as self-consolidating concrete. Its need from construction fields has increased, and consequently a variety of new-type polycarboxylates, base polymers for the admixture, are being formulated in these days. Synthesizing new polymers needs a quick, but reliable, test to evaluate its performance on concrete. The test is also asked for selecting the best applicable brand of them before a test concrete will be mixed. This paper proposes a channel flow test and its usage for the purpose. The proposed procedure for the test includes the mix proportion of a test mortar, the test method, and rheological interpretation of the test results.ope

Tailoring Low-field Strain Properties of [0.97Bi1/2(Na0.78K0.22)1/2TiO3-0.03LaFeO3]-Bi1/2(Na0.82K0.18)1/2TiO3 Lead-Free Relaxor/Ferroelectric Composites

We investigated the effect of Bi1/2(Na0.82K0.18)1/2TiO3 (BNKT) modification on the ferroelectric and electric-field-induced strain (EFIS) properties of lead-free 0.97Bi1/2(Na0.82K0.18)1/2TiO3-0.03LaFeO3 (BNKTLF) ceramics as a function of BNKT content (x= 0, 0.1, 0.2, 0.3, 0.5, and 1). BNKT-modified BNKTLF powders were synthesized using a conventional solid-state reaction method. As the BNKT content x increased from 0 to 1 the normalized electric-field-induced strain (Smax/Emax) was observed to increase at relatively low fields, i.e., below the poling field. Moreover, BNKTLF-30BNKT showed about 460 pm/V as low as at 3 kV/mm, which is a considerably high value among the lead-free systems reported so far. Consequently, it was confirmed that ceramic-ceramic composite, a mixture of an ergodic relaxor matrix and embedded ferroelectric seeds, is a salient way to make lead-free piezoelectrics practical with enhanced EFIS at low field as well as less hysterical.ope

SERCA2a gene transfer improves electrocardiographic performance in aged mdx mice

<p>Abstract</p> <p>Background</p> <p>Cardiomyocyte calcium overloading has been implicated in the pathogenesis of Duchenne muscular dystrophy (DMD) heart disease. The cardiac isoform of sarcoplasmic reticulum calcium ATPase (SERCA2a) plays a major role in removing cytosolic calcium during heart muscle relaxation. Here, we tested the hypothesis that SERCA2a over-expression may mitigate electrocardiography (ECG) abnormalities in old female mdx mice, a murine model of DMD cardiomyopathy.</p> <p>Methods</p> <p>1 × 10¹²viral genome particles/mouse of adeno-associated virus serotype-9 (AAV-9) SERCA2a vector was delivered to 12-m-old female mdx mice (N = 5) via a single bolus tail vein injection. AAV transduction and the ECG profile were examined eight months later.</p> <p>Results</p> <p>The vector genome was detected in the hearts of all AAV-injected mdx mice. Immunofluorescence staining and western blot confirmed SERCA2a over-expression in the mdx heart. Untreated mdx mice showed characteristic tachycardia, PR interval reduction and QT interval prolongation. AAV-9 SERCA2a treatment corrected these ECG abnormalities.</p> <p>Conclusions</p> <p>Our results suggest that AAV SERCA2a therapy may hold great promise in treating dystrophin-deficient heart disease.</p

Current Status of Image-Enhanced Endoscopy for Early Identification of Esophageal Neoplasms

Advanced esophageal cancer is known to have a poor prognosis. The early detection of esophageal neoplasms, including esophageal dysplasia and early esophageal cancer, is highly important for the accurate treatment of the disease. However, esophageal dysplasia and early esophageal cancer are usually subtle and can be easily missed. In addition to the early detection, proper pretreatment evaluation of the depth of invasion of esophageal cancer is very important for curative treatment. The progression of non-invasive diagnosis via image-enhanced endoscopy techniques has been shown to aid the early detection and estimate the depth of invasion of early esophageal cancer and, as a result, may provide additional opportunities for curative treatment. Here, we review the advancement of image-enhanced endoscopy-related technologies and their role in the early identification of esophageal neoplasms

A HISTORICAL APPROACH TO SYPHILIS INFECTION IN KOREA

From the end of the 15th century, syphilis spread worldwide, posing a serious threat to public health. Venereal syphilis has been a major research topic, not only in clinical medicine but also in paleopathology, especially because it is a disease of questionable origin and of high prevalence until the discovery of antibiotics. Syphilis in history has been studied extensively in Europe and the Americas, though less so in Asia. In this review, based on extant historical documents and available paleopathological data, we pinpoint the introduction and trace the spread of venereal syphilis in Korea to the end of the 19th century. This review provides fundamental information that will be of great help to future research on pre-20th century syphilis in Korea

REAM intensity modulator-enabled 10Gb/s colorless upstream transmission of real-time optical OFDM signals in a single-fiber-based bidirectional PON architecture

Reflective electro-absorption modulation-intensity modulators (REAM-IMs) are utilized, for the first time, to experimentally demonstrate colorless ONUs in single-fiber-based, bidirectional, intensity-modulation and direct-detection (IMDD), optical OFDM PONs (OOFDM-PONs) incorporating 25km SSMFs and OLT-side-seeded CW optical signals. The colorlessness of the REAM-IMs is characterized, based on which optimum REAM-IM operating conditions are identified. In the aforementioned PON architecture, 10Gb/s colorless upstream transmissions of end-to-end realtime OOFDM signals are successfully achieved for various wavelengths within the entire C-band. Over such a wavelength window, corresponding minimum received optical powers at the FEC limit vary in a range as small as <0.5dB. In addition, experimental measurements also indicate that Rayleigh backscattering imposes a 2.8dB optical power penalty on the 10Gb/s over 25km upstream OOFDM signal transmission. Furthermore, making use of on-line adaptive bit and power loading, a linear trade-off between aggregated signal line rate and optical power budget is observed, which shows that, for the present PON system, a 10% reduction in signal line rate can improve the optical power budget by 2.6dB. © 2012 Optical Society of America