2004ネン ナンキョク ニオケル イリョウ イガク ケンキュウ ニカンスル ケンキュウ シュウカイ ノ ホウコク

004年の「南極における医療・医学研究集会」が8月28日,国立極地研究所で開催された.主な内容は「南極の高所がヒトに与える影響」,「南極でのストレスがアミノ酸脂肪酸代謝に与える影響」,「越冬基地におけるレジオネラ菌調査」,「南極における紫外線障害とその対策」,「46次隊の医学研究計画」であった.16施設から合計22名が参加し,口頭発表10演題,ポスター発表1演題,文書発表1演題について,活発な討論が行われた.A meeting on Antarctic Medical Research was held at NIPR on August 28, 2004. Twenty two members participated in the meeting with ten oral presentations, one poster presentation and one report paper. The main subjects were The human responses in the Antarctic highland", The influence of the cold stress on the amino acids and lipid metabolism", Legionella contamination at the Antarctic wintering stations". The JARE-46 medical research program" was also reported and discussed

2006ネン ナンキョク イガク イリョウ ケンキュウ シュウカイ ホウコク

南極医学医療研究集会は,わが国の南極医学研究と医療問題についての研究成果を報告・討論し,次期の観測隊における医学研究に寄与することを目的として毎年行われている.2006年の本研究集会は8月26日,国立極地研究所講堂で行われた.27施設から42名が参加し18の演題報告がなされ,近年では最大規模の研究集会となった. 参加者は越冬経験医師をはじめ,共同研究を行っている大学や研究機関の研究者,関連領域の研究を行っている宇宙開発機構やスポーツ科学研究所などの研究者,南極に興味のある一般病院の臨床医など多彩であった. 2004年より昭和基地に導入されたテレビ会議システムを活用して,昭和基地の医師もリアルタイム映像で討論に参加した.また韓国,中国の越冬医師が初めて参加した.これは3カ国の極地研究所による事前の準備と連携により実現した.集会では各国の南極基地の医療状況や医学研究活動が報告され,活発な意見交換がなされた.南極医学医療研究分野におけるアジア連携の端緒となることが期待される.A workshop on Antarctic Medical Research and Medicine 2006 was held at the National Institute of Polar Research (NIPR) on 26 August, 2006. Forty two participants from 27 institutes attended. The members consist of medical doctors with Antarctic experience, human biologists, research scientists in other fields, logistic staff members of the expedition and also medical doctors interested in Antarctica. The current resident doctor at Syowa Station joined the discussion through a telecommunication system. Doctors with Antarctic experience from China and Korea also participated in the workshop. They gave presentations on their Antarctic activities, followed by an active discussion session. Eighteen presentations were given on various topics, including the International Polar Year (IPY) 2007-2008 in medical research, space medicine, telemedicine, an international comparative study of medical operations, psychological surveys, Antarctic high-altitude medicine, Legionella surveillance and nutritional studies

Red ginseng prevents doxorubicin-induced cardiomyopathy by inhibiting cell death via activating the Nrf2 pathway

Abstract Background Doxorubicin (DXR) is an effective chemotherapeutic agent. DOX-induced cardiomyopathy (DICM), a major limitation of DXR, is a complication with limited treatment options. We previously reported that Red Ginseng (steamed and dried the root of Panax Ginseng cultivated for over six years; RGin) is beneficial for the treatment of DICM. However, the mechanism underlying the action of RGin remains unclear. In this study, we investigated the mechanism of action underlying the efficacy of RGin in the treatment of DICM. Methods Four-week-old DBA/2 mice were divided into: vehicle, DXR, RGin, and DXR + RGin (n = 10/group). Mice were treated with DXR (4 mg/kg, once a week, accumulated 20 mg/kg, i.p.) or RGin (0.5 g/kg, three times a week, i.p.). To evaluate efficacy, the survival rate and left ventricular ejection fraction (LVEF) were measured as a measure of cardiac function, and cardiomyocytes were subjected to Masson trichrome staining. To investigate the mechanism of action, western blotting was performed to evaluate the expression of nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase 1, transferrin receptor (TfR), and other related proteins. Data were analyzed using the Easy R software. Between-group comparisons were performed using one-way analysis of variance and analyzed using a post-hoc Tukey test. Survival rates were estimated using the Kaplan–Meier method and compared using the log-rank test. P < 0.05 was considered statistically significant in all analyses. Results RGin treatment prolongs survival and protects against reduced LVEF. In the DXR group, Nrf2 was not activated and cell death was accelerated. Furthermore, there was an increase in the TfR levels, suggesting abnormal iron metabolism. However, the DXR + RGin group showed activation of the Nrf2 pathway and suppression of myocardial cell death. Furthermore, there was no increase in TfR expression, suggesting that there were no abnormalities in iron metabolism. Therefore, the mechanism of action of RGin in DICM involves an increase in antioxidant activity and inhibition of cell death through activation of the Nrf2 pathway. Conclusion RGin is a useful therapeutic candidate for DICM. Its efficacy is supported by the activation of the Nrf2 pathway, which enhances antioxidant activity and inhibits cell death

Meeting on Antarctic Medical Research in 2004

A meeting on Antarctic Medical Research was held at NIPR on August 28, 2004. Twenty two members participated in the meeting with ten oral presentations, one poster presentation and one report paper. The main subjects were The human responses in the Antarctic highland", The influence of the cold stress on the amino acids and lipid metabolism", Legionella contamination at the Antarctic wintering stations". The JARE-46 medical research program" was also reported and discussed