Fixed-dose combination of ivabradine and metoprolol in a patient with stable coronary artery disease: a case report

This article discusses a case of using fixed-dose combination of ivabradine/metoprolol in actual clinical practice

Prevalence of cardiovascular risk factors among men of different age groups in the city of Yekaterinburg

To assess the prevalence of risk factors for cardiovascular pathologies, a comparative study was carried out of 4 groups of men of different ages living in the Ekaterinburg city in order to analyze the frequency of occurrence, timely identification and modification of these factors in the early stages of the disease. The results of the study revealed the prevalence of high BMI in men, an increase in lipid profile, cholesterol, atherogenic index, and others. A regularity was revealed that with age, the frequency of occurrence of risk factors and their values increaseДля оценки распространённости факторов риска сердечнососудистых патологий было проведено сравнительное исследование 4 групп мужчин разных возрастов, проживающих в городе Екатеринбург с целью анализа частоты встречаемости, своевременного выявления и модификации этих факторов на ранних этапах заболевания. По результатам исследования выявлена распространенность у мужчин высокого ИМТ, патологических изменений показателей липидограммы, и других факторов риска. Выявлена закономерность, что с возрастом увеличиваются частота встречаемости факторов риска и их значимост

Comparative efficacy and safety of reperfusion therapy for acute myocardial infarction with ST-segment elevation in patients of middle and old age

For comparison features of reperfusion therapy in old and middle-age patients STEMI performed the study, including 136 patients aged 45 to 59 years and from 75 to 87 years old. This study assessed the complications and mortality rates depending on the age of the patient and the choice of reperfusion therapy. It is shown that old patients have a higher rate of complications of AMI and are characterized by large rates of mortality than those of middle age patients.С целью сравнения особенностей реперфузионной терапии у пациентов старческого и среднего возраста с OKCnST проведено исследование, включившее 136 пациентов в возрасте от 45 до 59 лет и от 75 до 87 лет. В исследовании были оценены госпитальные осложнения и показатели летальности в зависимости от возраста пациентов и выбора метода реперфузионной терапии. Показано, что пациенты старческого возраста имеют большее число осложнений ОИМ и характеризуются большими показателями летальности, чем пациенты среднего возраста

Evaluation of indicators of the annual course of therapy with alirocumab in an alternative dose

The aim of the study - description of a clinical evaluation of patients at very high cardio-vascular risk receiving longterm alirocumab at an alternative doseЦель исследования - описание клинического случая пациентки очень высокого сердечно-сосудистого риска, длительно принимающей алирокумаб в альтернативной дозе

Prevalence of cardiovascular risk factors among the population of Yekaterinburg

The purpose of the study is to study and analyze the prevalence of cardiovascular risk factors among women of different ages living in Yekaterinburg.Цель исследования – изучить и проанализировать распространённость факторов сердечно-сосудистого риска среди женщин разных возрастов, проживающих в г. Екатеринбург

Clinical manifestations of pulmonary thromboembolia in real practice

The article presents the results of the analysis of patients' medical records of the therapeutic and cardiological departments of the Central city hospital №1 of Ekaterinburg for the period from 21.10.2016 to 12.04.2018. The purpose was to identify clinical manifestations, that were the basis for conducting the computer tomography of the pulmonary artery with intravenous contrast, for the detection or exclusion of pulmonary embolism in real clinical practiceВ статье представлены результаты анализа историй болезни пациентов терапевтического и кардиологического отделений ГБУЗ СО «ЦГКБ №1» города Екатеринбурга за период с 21.10.2016 по 12.04.2018 гг, проведенного с целью определения клинических проявлений, являющихся основанием для проведения компьютерной томографии легочной артерии с контрастированием, с целью выявления или исключения тромбоэмболии легочной артерии (ТЭЛА) в реальной клинической практик

Clinical case of application of the drug alirokumab in an alternative dose

This article discusses a clinical example of the first use in the city of Yekaterinburg of a human monoclonal antibody against proprotein convertase of subtilisin-kexin type 9 (PCSK9) in a patient with hypercholesterolemia and a very high risk of cardiovascular diseases at a dose of 150 mg once every 4 weeksВ данной статье рассматривается клинический пример первого применения в городе Екатеринбург человеческого моноклонального антитела против пропротеиновой конвертазы субтилизин-кексинового типа 9 (PCSК9) у пациентки с гиперхолестеринемией и очень высоким риском сердечно-сосудистых заболеваний в дозе 150 мг 1 раз в 4 недел

QRISK-2 indicators in men without IHD at the age from 40 to 60 years in Ekaterinburg

To identify 10-year risk of development of myocardial infarction and insult men were asked to use a scale QRISK-2. 247 men were examined. In all of them the risk factors were taken into account: age, gender, smoking, static blood pressure.С целью выявления 10-летнего риска развития инфаркта миокарда и инсульта у мужчин было предложено использовать шкалу QRISK-2. Нами было исследовано 247 мужчин. У всех были учтены факторы риска: возраст, пол, курение, систолическое артериальное давление

The study of organelle DNA variability in alloplasmic barley lines in the NGS era

Alloplasmic lines are a suitable model for studying molecular coevolution and interrelations between genetic systems of plant cells. Whole chloroplast (cp) and mitochondrial (mt) genome sequences were obtained by the MiSeq System (Illumina). Organelle DNA samples were prepared from a set of 12 alloplasmic barley lines with different cytoplasms of Hordeum vulgare ssp. spontaneum and H. vulgare ssp. vulgare, as well as from their paternal varieties. A bioinformatic approach for analysis of NGS data obtained on an organellar DNA mix has been developed and verified. A comparative study of Hordeum organelle genomes' variability and disposition of polymorphic loci was conducted. Eight types of chloroplast DNA and 5 types of mitochondrial DNA were distinguished for the barley sample set examined. These results were compared with the previous data of a restriction fragment length polymorphism (RFLP) study of organelle DNAs for the same material. Formerly established data about a field evaluation of alloplasmic barley lines were revised in the light of information about organelle genomes gained after NGS. Totally 17 polymorphic loci were found at exons of chloroplast genomes. Seven of the SNPs were located in the genes of the Ndh complex. The nonsynonymous changes of nucleotides were detected in the matK, rpoCI, ndhK, ndhG and infA genes. Some of the SNPs detected are very similar in codon position and in the type of amino acid substitution to the places where RNA editing can occur. Thus, these results outline new perspectives for the future study of nuclear-cytoplasmic interactions in alloplasmic lines