1,080 research outputs found
Anomaly polynomial of E-string theories
We determine the anomaly polynomial of the E-string theory and its
higher-rank generalizations, that is, the 6d
superconformal theories on the worldvolume of one or multiple M5-branes
embedded within the end-of-the-world brane with symmetry.Comment: v2: 16 pages; typos correcte
Like-sign dimuon asymmetry of B0 meson and LFV in SU(5) SUSY GUT with S4 flavor symmetry
The like-sign dimuon charge asymmetry of the meson, which was reported in
the D\O Collaboration, is studied in the SU(5) SUSY GUT model with
flavor symmetry. Additional CP violating effects from the squark sector are
discussed in mixing process. The predicted like-sign charge
asymmetry is in the 2 range of the combined result of D\O and CDF
measurements. Since the SUSY contributions in the quark sector affect to the
lepton sector because of the SU(5) GUT relation, two predictions are given in
the leptonic processes: (i) both and the electron
EDM are close to the present upper bound, (ii) the decay ratios of
decays, and , are related to each other
via the Cabibbo angle : {\rm BR}(\tau \to e\gamma)/{\rm BR}(\tau
\to \mu\gamma)\sime \lambda_c^2. These are testable at future experiments.Comment: 33 pages, 4 figures, a footnote and references are adde
Electrophysiological analysis of mammalian cells expressing hERG using automated 384-well-patch-clamp
BACKGROUND: An in vitro electrophysiological assay system, which can assess compound effects and thus show cardiotoxicity including arrhythmia risks of test drugs, is an essential method in the field of drug development and toxicology. METHODS: In this study, high-throughput electrophysiological recordings of human embryonic kidney (HEK 293) cells and Chinese hamster ovary (CHO) cells stably expressing human ether-a-go-go related gene (hERG) were performed utilizing an automated 384-well-patch-clamp system, which records up to 384 cells simultaneously. hERG channel inhibition, which is closely related to a drug-induced QT prolongation and is increasing the risk of sudden cardiac death, was investigated in the high-throughput screening patch-clamp system. RESULTS: In the automated patch-clamp measurements performed here, K(v) currents were investigated with high efficiency. Various hERG channel blockers showed concentration-dependent inhibition, the 50 % inhibitory concentrations (IC(50)) of those blockers were in good agreement with previous reports. CONCLUSIONS: The high-throughput patch-clamp system has a high potential in the field of pharmacology, toxicology, and cardiac physiology, and will contribute to the acceleration of pharmaceutical drug development and drug safety testing
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