MODULAR DIFFERENTIAL EQUATIONS WITH REGULAR SINGULARITIES AT ELLIPTIC POINTS FOR THE HECKE CONGRUENCE SUBGROUPS OF LOW-LEVELS

In this paper, we give explicit expressions of modular differential equations with regular singularities at elliptic points for the Hecke subgroups of level 2, 3, and 4, and their solutions expressed in terms of the Gauss hypergeometric series. We also give quasimodular-form solutions for some modular differential equations

Refractory to treat Helicobacter cinaedi bacteremia with bilateral lower extremities cellulitis in an immunocompetent patient

AbstractHelicobacter cinaedi is known to cause bacteremia with multi-focal cellulitis, usually, among immunocompromised patients. We report here a 54-year-old Japanese man who was found to have bacteremia complicated with bilateral lower extremities cellulitis due to H. cinaedi. This patient did not have any immunocompromised conditions including Human Immunodeficiency Virus infection. In this patient, the cellulitis was multi-focal which is rare among immunocompetent patients. In addition, interestingly, the cellulitis was symmetrically on the both sides on the lower dorsal part of the extremities. The patient was treated with meropenem, which was considered as one of the best available agents, however, he required a prolonged antimicrobial treatment. During the admission, he underwent colonoscopy which was unremarkable, and his stool culture was also negative while on meropenem. Subsequently, he developed recurrent symptoms of the right lower extremity twice and each time he was treated with intravenous meropenem followed by oral minocycline. After the total of 12 weeks of antimicrobial treatment, his symptoms subsided. Clinicians should be aware of this organism when treating multi-focal, or symmetrical cellulitis even if the patients are immunocompetent

Rotigotine suppresses sleep-related muscle activity augmented by injection of dialysis patients’ sera in a mouse model of restless legs syndrome

Idiopathic restless legs syndrome (RLS) has a genetic basis wherein BTBD9 is associated with a higher risk of RLS. Hemodialysis patients also exhibit higher rates of RLS compared with the healthy population. However, little is known about the relationship of BTBD9 and end-stage renal disease to RLS pathophysiology. Here we evaluated sleep and leg muscle activity of Btbd9 mutant (MT) mice after administration of serum from patients with either idiopathic or RLS due to end-stage renal disease (renal RLS) and investigated the efficacy of treatment with the dopamine agonist rotigotine. At baseline, the amount of rapid eye movement (REM) sleep was decreased and leg muscle activity during non-REM (NREM) sleep was increased in MT mice compared to wild-type (WT) mice. Wake-promoting effects of rotigotine were attenuated by injection of serum from RLS patients in both WT and MT mice. Leg muscle activity during NREM sleep was increased only in MT mice injected with serum from RLS patients of ideiopatic and renal RLS. Subsequent treatment with rotigotine ameliorated this altered leg muscle activity. Together these results support previous reports showing a relationship between the Btbd9/dopamine system and RLS, and elucidate in part the pathophysiology of RLS

Apoptosis in the repair process of experimental proliferative glomerulonephritis

Apoptosis in the repair process of experimental proliferative glomerulonephritis. The recovery from the proliferative glomerulonephritis (GN) with reduction of hypercellularity is known in various experimental and human GN. To elucidate the participation of apoptosis in GN, we studied the experimental Thy-1.1 GN for six weeks. Apoptosis was recognized by both light and electron microscopy, and the biochemical expression of apoptosis was morphologically confirmed by in situ end-labeling method of fragmented DNA, using terminal deoxy-transferase. Mesangioproliferative GN was induced by a single administration of anti-Thy-1.1 monoclonal antibody in a rat. Mesangial cell proliferation started early in the process and the number of glomerular cells peaked from day 7 to day 10. Subsequently, the degree of proliferative lesion diminished with obvious reconstruction of the capillary structure, as well as decrease in the number of glomerular cells. During this period, proliferated mesangial cells returned to their original level of cellularity and apoptosis apparently increased in number among the glomeruli. Apoptosis was significantly noted from day 7 to week 4 and was in its maximum at day 10 to week 2. Following this period, by week 6 most of the glomeruli reverted to their original structure. The number of infiltrated neutrophils and macrophages in the glomeruli slowly decreased during the course of the disease, and a few apoptosis were also observed. It is concluded that proliferated glomerular cells regress by apoptosis in the repairing process of GN. Apoptosis plays an essential role in the recovery to the original glomerular structure in GN

Integrative Acceleration of First-Order Boolean Masking for Embedded IoT Devices

Physical attacks, especially side-channel attacks, are threats to IoT devices which are located everywhere in the field. For these devices, the authentic functionality is important so that the IoT system becomes correct, and securing this functionality against side-channel attacks is one of our emerging issues. Toward that, Coron et al. gave an efficient arithmetic-to-Boolean mask conversion algorithm which enables us to protect cryptographic algorithms including arithmetic operations, such as hash functions, from the attacks. Recently, Biryukov et al. improved it by locally optimizing subroutines of the conversion algorithm. In this paper, we revisit the algorithm. Unlike Biryukov et al., we improve the Coron et al.\u27s algorithm with integrative optimizations over the subroutines. The gains against these algorithms are about $22.6\%$ and $7.0\%$ in the general setting. We also apply our algorithm to HMAC-SHA-1 and have an experiment to show that the implementation on a test vehicle smartcard leaks no sensitive information with the ISO/IEC17825 test

Characteristics of Suppressor Macrophages Induced by Mycobacterial and Protozoal Infections in relation to Alternatively Activated M2 Macrophages

In the advanced stages of mycobacterial infections, host immune systems tend to change from a Th1-type to Th2-type immune response, resulting in the abrogation of Th1 cell- and macrophage-mediated antimicrobial host protective immunity. Notably, this type of immune conversion is occasionally associated with the generation of certain types of suppressor macrophage populations. During the course of Mycobacterium tuberculosis (MTB) and Mycobacterium avium-intracellulare complex (MAC) infections, the generation of macrophages which possess strong suppressor activity against host T- and B-cell functions is frequently encountered. This paper describes the immunological properties of M1- and M2-type macrophages generated in tumor-bearing animals and those generated in hosts with certain microbial infections. In addition, this paper highlights the immunological and molecular biological characteristics of suppressor macrophages generated in hosts with mycobacterial infections, especially MAC infection

Exact Error Bound of Cox-Rower Architecture for RNS Arithmetic

Residue Number System (RNS) is a method for representing an integer as an n-tuple of its residues with respect to a given base. Since RNS has inherent parallelism, it is actively researched to implement fast public-key cryptography using RNS. This paper derives the exact error bound of approximation on the Cox-Rower architecture which was proposed for RNS modular multiplication. This is the tightest bound ever found and enables us to find new parameter sets for the Cox-Rower architecture, which cannot be found with old bounds