行動と体温の概日変動を支配する共通および個別メカニズムの同定

京都大学新制・課程博士博士(薬科学)甲第23142号薬科博第141号新制||薬科||15(附属図書館)京都大学大学院薬学研究科医薬創成情報科学専攻(主査)教授 土居 雅夫, 教授 中山 和久, 教授 竹島 浩学位規則第4条第1項該当Doctor of Pharmaceutical SciencesKyoto UniversityDFA

急性肺障害ウサギモデルにおける神経調節補助換気が人工呼吸器誘発横隔膜障害に与える影響の検討

広島大学(Hiroshima University)博士(医学)Doctor of Philosophy in Medical Sciencedoctora

New Monte Carlo simulation for polycrystalline silicon thin-film transistor

科研費報告書収録論文(課題番号:06555103・試験研究(B)(1)・H6～H7/研究代表者:小柳, 光正/超高速光バスを有するモンテカルロ解析専用並列処理システムの試作

Advanced Gastric Neuroendocrine Carcinoma with an Adenocarcinoma Component

In the present study, we observed that the adenocarcinoma component in the mucosa was continuous with neuroendocrine carcinoma (NEC) in the deeper layers; this suggests the normal course of NEC carcinogenesis at the histological level. A 72-year-old man was admitted to our hospital with a chief complaint of tarry stools. Endoscopic examination of the upper gastrointestinal tract revealed a 2-cm tumor, with a deep central depression, surrounded by a smooth elevated area, in the middle of the stomach body. A biopsy showed that the tumor was a moderately differentiated gastric adenocarcinoma. The patient underwent total gastrectomy and standard lymph node dissection. The resected tumor was a 3.5 × 2.5 cm type 2 lesion. It comprised two elements at the histological level: (i) a moderately differentiated adenocarcinoma in the superficial portion of the mucous membrane layer, and (ii) NEC-like cells with dark, round nuclei and scant cytoplasm, presenting a solid and trabecular pattern, in the submucosal and muscularis propria layers. Immunohistochemical findings showed that the NEC-like cells were diffusely positive for chromogranin A, synaptophysin, neural cell adhesion molecule, and neuron-specific enolase, but were negative for carcinoembryonic antigen. The Ki-67 labeling index was 95%. The final pathological diagnosis was gastric NEC with an adenocarcinoma component and a high cellular proliferative potential

フィールドワーカーも満足させるモデリング

Open House, ISM in Tachikawa, 2013.6.14統計数理研究所オープンハウス（立川）、H25.6.14ポスター発

3次元軌跡データの基本モデルとその限界

Open House, ISM in Tachikawa, 2015.6.19統計数理研究所オープンハウス（立川）、H27.6.19ポスター発

大空を舞う鳥のことを知りたいモデリング

Open House, ISM in Tachikawa, 2012.6.15統計数理研究所オープンハウス（立川）、H24.6.15ポスター発

木の多い所は環境がいいから?昔、親がいたから?

Open House, ISM in National Center of Sciences Building, 2019.6.05統計数理研究所オープンハウス（学術総合センター）、R1.6.5ポスター発

DNAsynthesis and cell renewal in small and large intestines of mouse

DNA synthesis and cell renewal of mouse intestinal epithelium were studied with radioautography after injection of thymidine-H&#179; to know the difference of the mode of epithelial cell generation relating to the different frequency of cancer developement in several parts of small and large intestines. Succinic dehydrogensase activity was also observed by histochemical method. Renewal time of the intestinal epithelium of mouse is about three days throughout the intestine with somewhat longer time in rectum and anus, and relatively shorter one in ileum compared to the other parts of the intestine. Daily regenerating rate was low in large intestine, especially in rectum and anus. Strong activity of succinic dehydrogenase appeared in the bottom of crypt and seems to be correlated to the active cell division. Epithelial cells in large intestine move very slowly upward and few of them seem to move to the opposite side or stay long time at one place. Intermitotic time is about 27 hours in small intestine and about 40 hours in large intestine. These suggest some relations between the mode of the epthelial cell renewal and cancer development. Because in human the frequency of cancer development is very high in large intestine, rectum and anus, and the epithelial renewal of these areas is supposed to be delayed similarly as in mice.</p