2 or 3 Surveys on the Bile Pigment Metabolism in Time Suffering from Acatalasenemia

Certain examinations were done from the aspect of bile pigment metabolism on those people within whose blood there is found almost no catalase, which has resulted as follows: 1. As the hemoglobin quantity estimated for the patient in this disease proving normal, and urinal propendyopent negative, it would not be perfectly true to say that the physical significance for intra-blood-cell catalase serves only as antidestruction due to hemoglobin against H2O2 that has been produced when oxidation in vivo has taken place. 2. In the process to turn bile pigment out of hemoglobin in vitro, when catalase should be in lack, the production of verdohemoglobin feels urged, attaining its height quickly; which, in turn urges a decrease that would happen following it. 3. In the above-mentioned experiment in vitro, generally, l-ascorbic acid helps in main in the production of verdohemoglobin on its initial reaction; successively, participating with velocity toward its destruction, at the brink where verdohemoglobin has reached its top value. 4. The amount respectively of easily split off blood iron, serum iron, as well as blood bilirubin in the tested person's blood, has indicated normal value. Consequently, if it would be surmised from such standpoint as bilirubin metabolism, persons without catalase in their blood might be deemed to be healthy

Penetration of the sigmoid colon to the posterior uterine wall secondary to diverticulitis: a case report

<p>Abstract</p> <p>Introduction</p> <p>Penetration of the colon to the posterior uterine wall secondary to diverticulitis is unusual, with diagnostic methods not yet established. Non-invasive imaging, such as computed tomography and magnetic resonance imaging may help to establish a proper diagnosis, but confirmation may be reached only after surgical exploration.</p> <p>Case presentation</p> <p>We report the case of a 78-year-old Japanese woman who presented with a low grade fever and mild diarrhea which occurred two or three times a week. Computed tomography and magnetic resonance imaging demonstrated a capsular lesion including an air structure with a diameter of 5 cm, between the posterior aspect of the uterine body and the sigmoid colon. A gastrograffin enema and colonoscopy demonstrated a giant diverticulum of the sigmoid colon with no evidence of malignancy. These data confirmed the diagnosis of diverticulitis complicated by a giant diverticulum. Because of a relapsing fever after therapy with antibiotics, the patient had en bloc surgical treatment of the uterus, fallopian tubes, ovaries and sigmoid colon, the organs involved in the diverticulitis, followed by an uneventful recovery.</p> <p>Conclusion</p> <p>This is a rare case report of penetration of the sigmoid colon to the posterior uterine wall secondary to diverticulitis.</p

Biomarker discovery for practice of precision medicine in hypopharyngeal cancer: a theranostic study on response prediction of the key therapeutic agents

Background: Hypopharyngeal cancer is a relatively rare malignancy with poor prognosis. Current chemotherapeutic algorithm is still far from personalized medicine, and the identification of the truly active therapeutic biomarkers and/or targets is eagerly awaited.Methods: Venturing to focus on the conventional key chemotherapeutic drugs, we identified the most correlative genes (and/or proteins) with cellular sensitivity to docetaxel (TXT), cisplatin (CDDP) and 5-fluorouracil (5-FU) in the expression levels, through 3 steps approach: genome-wide screening, confirmation study on the quantified expression levels, and knock-down and transfection analyses of the candidates. The probable action pathways of selected genes were examined by Ingenuity Pathway Analysis using a large-scale database, The Cancer Genome Atlas.Results: The first genome-wide screening study derived 16 highly correlative genes with cellular drug sensitivity in 15 cell lines (|R| > 0.8, P 0.5, P Conclusion: We newly propose 4 molecules -AGR2, PDE4D,NINJ2 and CDC25B) as the powerful exploratory markers for prediction of cellular response to 3 key chemotherapeutic drugs in hypopharyngeal cancers and also suggest their potentials to be the therapeutic targets, which could contribute to the development of precision medicine of the essential chemotherapy in hypopharyngeal patients.</p

多剤耐性カンジダおよび細菌に対するカスポファンギンの新たな抗微生物活性

長崎大学学位論文 [学位記番号]博（医歯薬）甲第1326号 [学位授与年月日]令和3年3月22

Ab initio molecular dynamics simulation of ethanol decompositionon platinum cluster at initial stage of carbon nanotube growth

tEthanol decomposition on a platinum cluster is investigated by ab initio MD simulation. As the dehydro-genation proceeds, the Mulliken charge of the methylene carbon becomes a positive value, whereas thatof the methyl carbon keeps a negative value. Especially, the Mulliken charge of the methylene carbonin CHxCO (x = 0, 1, 2 and 3) fragment molecules takes a large positive value. These fragment moleculescorrespond to those with C C bond that dissociated in the MD simulation. It suggests the large deviationin the Mulliken charge between methylene and methyl carbons is the key factor inducing the C C bonddissociation