2 research outputs found
Baseline observations from the POSSIBLE EU® study: characteristics of postmenopausal women receiving bone loss medications
Summary: Prospective Observational Scientific Study Investigating Bone Loss Experience in Europe (POSSIBLE
EU®) is an ongoing longitudinal cohort study that utilises
physician- and patient-reported measures to describe the
characteristics and management of postmenopausal women
on bone loss therapies. We report the study design and
baseline characteristics of 3,402 women recruited from
general practice across five European countries.
Purpose The POSSIBLE EU® is a study describing the
characteristics and management of postmenopausal women
receiving bone loss medications.
Methods: Between 2005 and 2008, general practitioners
enrolled postmenopausal women initiating, switching or
continuing treatment with bone loss treatment in France,
Germany, Italy, Spain and the UK. Patients and physicians
completed questionnaires at study entry and at 3-month
intervals, for 1 year.
Results: Of 3,402 women enrolled (mean age 68.2 years
[SD] 9.83), 96% were diagnosed with low bone mass; 55%
of these using dual energy X-ray absorptiometry. Most
women (92%) had comorbidities. Mean minimum T score
(hip or spine) at diagnosis was −2.7 (SD 0.89; median −2.7
[interquartile range, −3.2, −2.2]) indicating low bone
mineral density. Almost 40% of the women had prior
fractures in adulthood, mostly non-vertebral, non-hip in
nature, 30% of whom had at least two fractures and more
than half experienced moderate/severe pain or fatigue.
Bisphosphonates were the most common type of bone loss
treatment prescribed in the 12 months preceding the study.
Conclusions POSSIBLE EU® characterises postmenopausal
women with low bone mass, exhibiting a high rate of
prevalent fracture, substantial bone fragility and overall
comorbidity burden. Clinical strategies for managing
osteoporosis in this population varied across the five
participating European countries, reflecting their different
guidelines, regulations and standards of care
Baseline observations from the POSSIBLE EU® study: characteristics of postmenopausal women receiving bone loss medications
Summary: Prospective Observational Scientific Study Investigating Bone Loss Experience in Europe (POSSIBLE EU®) is an ongoing longitudinal cohort study that utilises physician- and patient-reported measures to describe the characteristics and management of postmenopausal women on bone loss therapies. We report the study design and baseline characteristics of 3,402 women recruited from general practice across five European countries. Purpose: The POSSIBLE EU® is a study describing the characteristics and management of postmenopausal women receiving bone loss medications.Methods: Between 2005 and 2008, general practitioners enrolled postmenopausal women initiating, switching or continuing treatment with bone loss treatment in France, Germany, Italy, Spain and the UK. Patients and physicians completed questionnaires at study entry and at 3-month intervals, for 1 year. Results: Of 3,402 women enrolled (mean age 68.2 years [SD] 9.83), 96% were diagnosed with low bone mass; 55% of these using dual energy X-ray absorptiometry. Most women (92%) had comorbidities. Mean minimum T score (hip or spine) at diagnosis was ?2.7 (SD 0.89; median ?2.7 [interquartile range, ?3.2, ?2.2]) indicating low bone mineral density. Almost 40% of the women had prior fractures in adulthood, mostly non-vertebral, non-hip in nature, 30% of whom had at least two fractures and more than half experienced moderate/severe pain or fatigue. Bisphosphonates were the most common type of bone loss treatment prescribed in the 12 months preceding the study. Conclusions: POSSIBLE EU® characterises postmenopausal women with low bone mass, exhibiting a high rate of prevalent fracture, substantial bone fragility and overall comorbidity burden. Clinical strategies for managing osteoporosis in this population varied across the five participating European countries, reflecting their different guidelines, regulations and standards of care. <br/