Measuring the Contribution to the Economy of Investments in Renewable Energy: Estimates of Future Consumer Gains

In this paper we develop a cost index–based measure of the expected consumer welfare gains from innovation in electricity generation technologies. To illustrate our approach, we estimate how much better off consumers would be from 2000 to 2020 as renewable energy technologies continue to be improved and gradually adopted, compared with a counterfactual scenario that allows for continual improvement of conventional technology. We proceed from the position that the role and prospects of renewable energy are best assessed within a market setting that considers competing energy technologies and sources. We evaluate five renewable energy technologies used to generate electricity: solar photovoltaics, solar thermal, geothermal, wind, and biomass. For each, we assume an accelerated adoption rate due to technological advances, and we evaluate the benefits against a baseline technology, combined-cycle gas turbine, which experts cite as the conventional technology most likely to be installed as incremental capacity over the next decade. We evaluate benefits against both the conventional combined-cycle gas turbine prevalent at this time and a more advanced combined-cycle gas turbine expected to be employed during the coming decade. We estimate the model for two geographic regions of the nation for which renewable energy is, or can be expected to be, a somewhat sizable portion of the electricity market—California and the north central United States. In present-value terms we find that median consumer welfare gains over 20 years vary markedly among the renewable technologies, ranging from large negative values (welfare losses) to large positive values (welfare gains). The effect of uncertainty can lead to estimates that are 20% to 40% larger or smaller than median predicted values. Our results suggest that portfolios that give equal weight to the use of each generation technology are likely to lead to consumer losses in our regions, regardless of the role of the externalities that we consider. However, when the portfolio is more heavily weighted toward certain renewables, consumer gains can be positive.energy economics, technical change

Anthocyanin Profile of Euphorbia Pulcherrima (Poinsettia) and the Effects of High Temperature on Anthocyanin Content and Dihydroflavonol 4-Reductase (DFR) Gene Expression

Ph.D

Climate Diagnostics of the Extreme Floods in Peru During Early 2017

From January through March 2017, a series of extreme precipitation events occurred in coastal Peru, causing severe floods with hundreds of human casualties and billions of dollars in economic losses. The extreme precipitation was a result of unusually strong recurrent patterns of atmospheric and oceanic conditions, including extremely warm coastal sea surface temperatures (SST) and weakened trade winds. These climatic features and their causal relationship with the Peruvian precipitation were examined. Diagnostic analysis and model experiments suggest that an atmospheric forcing in early 2017, which was moderately linked to the Trans-Niño Index (TNI), initiated the local SST warming along coastal Peru that later expanded to the equator. In January 2017, soil moisture was increased by an unusual expansion of Amazonian rainfall. By March, localized and robust SST warming provided positive feedback to the weakening of the trade winds, leading to increased onshore wind and a subsequent enhancement in rainfall. The analysis points to a tendency towards more frequent and stronger variations in the water vapor flux convergence along the equator, which is associated with the increased precipitation in coastal Peru

Lovastatin Corrects Excess Protein Synthesis and Prevents Epileptogenesis in a Mouse Model of Fragile X Syndrome

Many neuropsychiatric symptoms of fragile X syndrome (FXS) are believed to be a consequence of altered regulation of protein synthesis at synapses. We discovered that lovastatin, a drug that is widely prescribed for the treatment of high cholesterol, can correct excess hippocampal protein synthesis in the mouse model of FXS and can prevent one of the robust functional consequences of increased protein synthesis in FXS, epileptogenesis. These data suggest that lovastatin is potentially disease modifying and could be a viable prophylactic treatment for epileptogenesis in FXS.FRAXA Research FoundationNational Institute of Mental Health (U.S.)Eunice Kennedy Shriver National Institute of Child Health and Human Development (U.S.)Simons Foundatio

The novel ZIP4 regulation and its role in ovarian cancer

Our RNAseq analyses revealed that ZIP4 is a top gene up-regulated in more aggressive ovarian cancer cells. ZIP4's role in cancer stem cells has not been reported in any type of cancer. In addition, the role and regulation of ZIP4, a zinc transporter, have been studied in the context of extracellular zinc transporting. Factors other than zinc with ZIP4 regulatory effects are essentially unknown. ZIP4 expression and its regulation in epithelial ovarian cancer cells was assessed by immunoblotting, quantitative PCR, or immunohistochemistry staining in human ovarian tissues. Cancer stem cell-related activities were examined to evaluate the role of ZIP4 in human high-grade serous ovarian cancer cells in vitro and in vivo. RNAi and CRISPR techniques were used to knockdown or knockout ZIP4 and related genes. Ovarian cancer tissues overexpressed ZIP4 when compared with normal and benign tissues. ZIP4 knockout significantly reduced several cancer stem cell-related activities in EOC cells, including proliferation, anoikis-resistance, colony-formation, spheroid-formation, drug-resistance, and side-population in vitro. ZIP4-expressing side-population highly expressed known CSC markers ALDH1 and OCT4. ZIP4 knockout dramatically reduced tumorigenesis and ZIP4 overexpression increased tumorigenesis in vivo. In addition, the ZIP4-expressing side-population had the tumor initiating activity. Moreover, the oncolipid lysophosphatic acid effectively up-regulated ZIP4 expression via the nuclear receptor peroxisome proliferator-activated receptor gamma and lysophosphatic acid 's promoting effects in cancer stem cell-related activities in HGSOC cells was at least partially mediated by ZIP4 in an extracellular zinc-independent manner. Our critical data imply that ZIP4 is a new and important cancer stem cell regulator in ovarian cancer. Our data also provide an innovative interpretation for the apparent disconnection between low levels of zinc and up-regulation of ZIP4 in ovarian cancer tissues

A conceptual enquiry into communities of practice as praxis in international doctoral education

Undertaking a PhD entails diverse and multi-faceted challenges as doctoral researchers enter a distinct academic culture that requires transition to a new level and threshold of learning – with both knowledge acquisition and production at the core. While doctoral researchers are expected to secure different dimensions of knowledge, which necessitates meaningful ‘dialogue’ with experts, the colossal task is still ironically associated with isolated doctoral experience and somewhat limited postgraduate supervision provision. With the extra concerns typically confronting the international doctoral cohort, the pressure tends be intensified, and may lead to psychological well-being concerns. Nevertheless, there is evidence from the literature that highlights the often unacknowledged forms of learning opportunities and support mechanisms via community participation. By employing communities of practice as the main framework, this conceptual paper exemplifies the crucial role played by these communities – how these communities serve to scaffold doctoral researchers’ academic progress, support their psychological adjustments, and reinforce the crucial, but perhaps limited, formal doctoral support provision. By featuring effective examples of educational praxis via these communities, our paper offers a holistic understanding of formal and informal infrastructures as part of the wider doctoral ecology with a view to achieving a more holistic and meaningful doctoral experience

A conceptual enquiry into communities of practice as praxis in international doctoral education

Undertaking a PhD entails diverse and multi-faceted challenges as doctoral researchers enter a distinct academic culture that requires transition to a new level and threshold of learning – with both knowledge acquisition and production at the core. While doctoral researchers are expected to secure different dimensions of knowledge, which necessitates meaningful ‘dialogue’ with experts, the colossal task is still ironically associated with isolated doctoral experience and somewhat limited postgraduate supervision provision. With the extra concerns typically confronting the international doctoral cohort, the pressure tends be intensified, and may lead to psychological well-being concerns. Nevertheless, there is evidence from the literature that highlights the often unacknowledged forms of learning opportunities and support mechanisms via community participation. By employing communities of practice as the main framework, this conceptual paper exemplifies the crucial role played by these communities – how these communities serve to scaffold doctoral researchers’ academic progress, support their psychological adjustments, and reinforce the crucial, but perhaps limited, formal doctoral support provision. By featuring effective examples of educational praxis via these communities, our paper offers a holistic understanding of formal and informal infrastructures as part of the wider doctoral ecology with a view to achieving a more holistic and meaningful doctoral experience

Waterproofed Photomultiplier Tube Assemblies for the Daya Bay Reactor Neutrino Experiment

In the Daya Bay Reactor Neutrino Experiment 960 20-cm-diameter waterproof photomultiplier tubes are used to instrument three water pools as Cherenkov detectors for detecting cosmic-ray muons. Of these 960 photomultiplier tubes, 341 are recycled from the MACRO experiment. A systematic program was undertaken to refurbish them as waterproof assemblies. In the context of passing the water leakage check, a success rate better than 97% was achieved. Details of the design, fabrication, testing, operation, and performance of these waterproofed photomultiplier-tube assemblies are presented.Comment: 16 pages, 11 figures. Submitted to Nucl. Instr. Met

Cyanine dye mediated mitochondrial targeting enhances the anti-cancer activity of small-molecule cargoes

Organelle-specific delivery systems are of significant clinical interest. We demonstrate the use of common cyanine dyes Cy3 and Cy5 as vectors for targeting and delivering cargoes to mitochondria in cancer cells. Specifically, conjugation to the dyes can increase cytotoxicity by up to 1000-fold

Direct Classification of All American English Phonemes Using Signals From Functional Speech Motor Cortex

Although brain-computer interfaces (BCIs) can be used in several different ways to restore communication, communicative BCI has not approached the rate or efficiency of natural human speech. Electrocorticography (ECoG) has precise spatiotemporal resolution that enables recording of brain activity distributed over a wide area of cortex, such as during speech production. In this study, we investigated words that span the entire set of phonemes in the General American accent using ECoG with 4 subjects. We classified phonemes with up to 36% accuracy when classifying all phonemes and up to 63% accuracy for a single phoneme. Further, misclassified phonemes follow articulation organization described in phonology literature, aiding classification of whole words. Precise temporal alignment to phoneme onset was crucial for classification success. We identified specific spatiotemporal features that aid classification, which could guide future applications. Word identification was equivalent to information transfer rates as high as 3.0 bits/s (33.6 words min), supporting pursuit of speech articulation for BCI control