Suppression of exercise-induced neutrophilia and lymphopenia in athletes by cystine/theanine intake: a randomized, double-blind, placebo-controlled trial

<p>Abstract</p> <p>Background</p> <p>Intense exercise induces increased blood neutrophil counts and decreased lymphocyte counts, and leads to inflammation and immunosuppression. It was previously reported that cystine and theanine (CT) supplementation by long-distance runners before a training camp suppressed the changes of these blood parameters observed in un-supplemented control subjects after the camp. The purpose of the present study was to determine the effects of CT supplementation on the inflammatory response and immune state before and after intense endurance exercise in long-distance runners at a training camp.</p> <p>Methods</p> <p>Sixteen long-distance runners were allocated to one of two groups given CT supplements (700 mg cystine + 280 mg theanine daily) or placebo (8 in each group) for 7 days prior to and during a 9-day training camp. Daily run training averaged 19.9 km/day prior to the camp and 28.6 km/day during the camp. On the initial and final days of the camp, blood samples were collected before and after 15 km morning interval running workouts (1000 m × 15 times) and analyzed for neutrophil and lymphocyte counts and myoglobin.</p> <p>Results</p> <p>The relative change in exercise-induced blood neutrophil count (% of pre-exercise values) was significantly lower in the CT group than in the placebo group (163.3 ± 43.2% <it>vs. </it>200.4 ± 19.6%, p = 0.044) on the initial day of camp, but not on the last day. The decline in lymphocyte count (% of pre-exercise values) was significantly less in the CT group than in the placebo group (60.2 ± 19.2% <it>vs. </it>36.2 ± 12.0%, p = 0.010) on the initial day of camp, but not on the last day. In blood myoglobin, there was a trend toward lower % of pre-exercise values in the CT group (p < 0.09) on both measurement days.</p> <p>Conclusion</p> <p>CT supplementation significantly attenuated the increase in neutrophil count and the reduction in lymphocyte count induced by intense endurance exercise. These results suggest that CT supplementation may suppress the exercise-induced fluctuation of the blood immunocompetent cells and may help to reduce the alteration of the immune state.</p

Efficacy of SGLT2 inhibitors in IgA nephropathy associated with alcoholic liver cirrhosis accompanied by nephrotic syndrome: a case report

We present a 51-year-old male patient with a history of Child-Pugh Grade B alcoholic liver cirrhosis (ALC) who developed renal impairment (serum creatinine of 2.00 mg/dL) and nephrotic syndrome (a urinary protein level of 4.35 g/gCr). The patient was diagnosed with immunoglobulin A nephropathy (IgAN) associated with ALC based on findings from comprehensive evaluations, including markedly elevated serum IgA levels (883.7 mg/dL), a kidney biopsy revealing significant IgA deposition in the para-mesangial area, and a liver diagnosis showing long-standing advanced ALC. Our treatment approach involved initiating dapagliflozin therapy, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, alongside strict alcohol abstinence. Remarkably, the patient demonstrated a dramatic reduction in proteinuria within one week of dapagliflozin administration. No hypoglycemic events were observed. This case adds valuable clinical insights into the potential therapeutic role of SGLT2 inhibitors in IgAN associated with ALC. Specifically, in cases where conventional steroid therapies may be contraindicated due to coexisting comorbidities such as diabetes or obesity, dapagliflozin emerges as a potentially efficacious alternative. Further investigations are warranted to validate these preliminary observations

Cystine and Theanine as Stress-Reducing Amino Acids&mdash;Perioperative Use for Early Recovery after Surgical Stress

Perioperative nutritional therapy requires the consideration of metabolic changes, and it is desirable to reduce stress aiming at early metabolic normalization. Glutathione (GSH) is a tripeptide composed of glutamic acid, cysteine, and glycine. It is one of the strongest antioxidants in the body and important for adjusting immune function. Cystine and theanine (&gamma;-glutamylethylamide) provide substrates of GSH, cysteine and glutamic acid, promoting the synthesis of GSH. It has been reported that the ingestion of cystine (700 mg) and theanine (280 mg) exhibits inhibitory effects against excess inflammation after strong exercise loads in athletes, based on which its application for invasive surgery has been tried. In patients undergoing gastrectomy, ingestion of cystine (700 mg) and theanine (280 mg) for 10 days from 5 days before surgery inhibited a postoperative increase in resting energy expenditure, promoted recovery from changes in interleukin-6, C-reactive protein, lymphocyte ratio, and granulocyte ratio and inhibited an increase in body temperature. In a mouse small intestine manipulation model, preoperative 5-day administration of cystine/theanine inhibited a postoperative decrease in GSH in the small intestine and promoted recovery from a decrease in behavior quantity. Based on the above, cystine/theanine reduces surgical stress, being useful for perioperative management as stress-reducing amino acids

Pocket Guide for Medical Physicists Supporting Response to a Nuclear or Radiological Emergency

The medical management of individuals involved in a nuclear or radiological emergency requires specially trained personnel. Lessons learned from previous events have demonstrated that caring for these individuals calls for a multidisciplinary team of health care professionals if the response is to be effective. All hospitals offering medical radiation services (e.g. radiology, radiotherapy, nuclear medicine) have medical physicists who are part of the clinical team, with special responsibility for the proper and safe application of ionizing radiation. Using this reservoir of radiation protection experts in emergency and preparedness teams is good medical practice. Clinical medical physicists working in hospitals have in-depth knowledge of radiation dosimetry, dose reconstruction and dose measurement procedures. They constitute a unique group of professionals who, with the appropriate training, can provide effective support for emergency preparedness and response activities. Some sections of this publication were developed under the NA/21 Project supported by the Government of Japan within the IAEA Action Plan on Nuclear Safety, in cooperation with the International Organization for Medical Physics. This publication has been endorsed by the American Association of Physicists in Medicine, European Association of Nuclear Medicine, International Association of Radiopathology, International Federation of Red Cross and Red Crescent Societies, International Organization for Medical Physics and Latin American Association of Societies of Nuclear Medicine and Biology. The IAEA officers responsible for this publication were E.D. Herrera Reyes of theIncident and Emergency Centre, and T. Berris and A. Meghzifene of the Division of Human Health