Pion Energy Reconstruction by the Local Hadronic Calibration Method with ATLAS Combined Test Beam 2004 data

The pion energy reconstruction by the local hadronic calibration method on the basis of the 2004 combined test beam data in the energy range 10 -- 350 GeV and $\eta = 0.25$ is performed. In this method energies deposited in each cell are weighted. The weights are determined by the Monte Carlo simulation using Calibration Hits software. We have modified this method by applying cuts in weights. The obtained fractional energy resolution with the conventional method of determination of the energy deposit in the dead material between LAr and Tile calorimeters is $\sigma/E = (67\pm2)\%/\sqrt{E} \oplus (3.9\pm0.2)\% \oplus (95\pm22)\%/E$. This is about 1.5 times better than the results for the hadronic calibration method obtained by the Oxford-Stockholm group and slightly better than the H1 method results for CTB04 obtained by Pisa group. The energy linearity is within $\pm$1\%. We have determined the general normalization constant of 0.91 for which the mean value linearity for the weight cut of 1.05 is about 1. At using this normalization constant the energy resolution has not worsen. We have corrected the cesium miscalibration of the $Tile_1$ and $Tile_2$ longitudinal samplings. The mean value of energy linearity has been increased by about 1\% and becomes equal to 1.002$\pm$0.002. The energy resolution did not change. We have performed weighting without knowing of the beam energies. For this the special procedure has been developed. In this case the energy resolution shows 9\% degradation. Linearities are within $\pm$1\%. We have applied the Neural Networks to the determination of the energy deposit between LAr and Tile calorimeters. The essential improvement of energy resolution is obtained. In this case we have reached the projected energy resolution for hadrons in the ATLAS detector $\sigma/E = 50\%/\sqrt{E} \oplus 3\%$

Artificial Neural Networks for reconstruction of energy losses in dead materials between barrel LAr and Tile calorimeters: exploration and results

In the course of computational experiments with Monte-Carlo events for ATLAS Combined Test Beam 2004 setup Artificial Neural Networks (ANN) technique was applied for reconstruction of energy losses in dead materials between barrel LAr and Tile calorimeters (Edm). The constructed ANN procedures exploit as their input vectors the information content of different sets of variables (parameters) which describe particular features of the hadronic shower of an event in ATLAS calorimeters. It was shown that application of ANN procedures allows one to reach 40% reduction of the Edm reconstruction error compared to the conventional procedure used in ATLAS collaboration. Impact of various features of a shower on the precision of $Edm$ reconstruction is presented in detail. It was found that longitudinal shower profile information brings greater improvement in $Edm$ reconstruction accuracy than cell energies information in LAr3 and Tile1 samplings

Об алгоритме расщепления носителя для индуцированных кодов

In the paper, the analysis of the stability of the McEliece-type cryptosystem on induced codes for key attacks is examined. In particular, a model is considered when the automorphism group is trivial for the base code C, on the basis of which the induced code Flq ⊗ C is constructed. In this case, as shown by N. Sendrier in 2000, there exists such a mapping, called a complete discriminant, by means of which a secret permutation that is part of the secret key of a McEliece-type cryptosystem can be effectively found. The automorphism group of the code Flq ⊗ C is nontrivial, therefore there is no complete discriminant for this code. This suggests a potentially high resistance of the McEliece-type cryptosystem on the code Flq ⊗ C. The algorithm for splitting the support for the code Flq ⊗ C is constructed and the efficiency of this algorithm is compared with the existing attack on the key of the McElice type cryptosystem based on the code Flq ⊗ C.В 2000 г. Н. Сендриер показал, что если для линейного [n, k, d]-кода C(⊆ Fnq ) длины n и размерности k с кодовым расстоянием d группа автоморфизмов PAut(C) этого кода тривиальна, то может быть построен детерминированный алгоритм расщепления носителя, позволяющий для кода D, перестановочно-эквивалентного коду C, найти такую перестановку σ, что σ(C) = D. Этот алгоритм, в частности, может быть применен для осуществления атаки на ключ кодовой криптосистемы типа Мак-Элиса на коде C. Целью настоящей работы является построение и анализ алгоритма расщепления носителя для кода Flq ⊗ C, индуцированного кодом C, l ∈ N. Так как группа автоморфизмов PAut(Flq ⊗ C) нетривиальна даже в случае, когда группа автоморфизмов базового кода C тривиальна, то это позволяет предположить потенциально высокую стойкость криптосистемы типа Мак-Элиса на коде Flq ⊗C к атаке на основе расщепления носителя. В работе строится алгоритм расщепления носителя для кода Flq ⊗ C и сравнивается эффективность этого алгоритма с имеющейся атакой на ключ криптосистемы типа Мак-Элиса на основе кода Flq ⊗ C

Трансплантация легких при первичной легочной артериальной гипертензии: особенности периоперационного периода

Lung transplantation (LT) for idiopathic pulmonary arterial hypertension (IPAH) now is the only radical treatment of this disease.Aim: to analyze own experience of performing LT in patients with IPAH.Materials and methods. 8 adult IPAH patients, who underwent LT between 2014 and october 2018, were included. In 7 of 8 patients undergoing bilateral lung transplantation on intraoperative venoarterial extracorporeal membrane oxygenation (VA ECMO) with prolongation into the postoperative period.Results. VA ECMO support was prolonged into postoperative period 6 and 7 days respectively in 2 (25,0%) patients and 3 days in 6 (75,0%) patients. Hospital mortality in IPAH patients was 1.Conclusions. Own experience demonstrates that LT is an effective method of treatment in patients with IPAH. Hospital, 1- and 3-year survival rates for the patient collective were 87.5, 75.0 and 75.0% respectively.Первичная легочная артериальная гипертензия (ПЛАГ) – необратимое заболевание, единственным методом радикального лечения которого является трансплантация легких (ТЛ).Цель исследования: анализ собственного опыта выполнения ТЛ у пациентов с ПЛАГ.Материалы и методы. В исследование включили 8 взрослых реципиентов, которым была выполнена ТЛ в период с 2014-го по октябрь 2018 г. Всем реципиентам была выполнена двусторонняя последовательная трансплантация легких. У 7 из 8 реципиентов ТЛ осуществляли в условиях периферической ВА ЭКМО.Результаты. В послеоперационном периоде первичная дисфункция 3-й степени по классификации ISHLT развилась у 2 (25,0%) из 8 реципиентов, которая проявилась невозможностью прекращения ВА ЭКМО. Общая продолжительность применения ЭКМО у этих пациентов (n = 2) составила 6 и 7 суток. У других 6 (75,0%) реципиентов проявления ранней дисфункции пересаженных легких не носили столь напряженного характера (2-я степень по классификации ISHLT), и продолжительность послеоперационной ВА ЭКМО составила 3 суток. Госпитальная летальность у реципиентов легких, оперированных по поводу ЛАГ, составила 1 наблюдение.Заключение. Собственный опыт демонстрирует, что ТЛ является эффективной лечебной мерой у пациентов с ПЛАГ с показателями госпитальной, 1- и 3-летней выживаемости соответственно 87,5; 75,0 и 75,0%

Лечение экспираторного стеноза трахеи в сочетании с бронхоэктатической болезнью у реципиента донорских легких (первое наблюдение в Российской Федерации)

Lung transplantation is the final treatment option for end-stage lung failure. In 2019, 63,530 lung transplants were performed worldwide [13]. Due to the variety of diseases causing patients to resort to lung transplant surgeries, there is a wide range of different complications and conditions that are subject to an individual clinical approach to determine treatment tactics. Each case is of great clinical interest due to the small amount of these operations and the complexity of postoperative rehabilitation, which requires a multidisciplinary approach [12]. We present a report on a surgical treatment of expiratory tracheal stenosis in combination with bronchiectasis in a lung recipient.Трансплантация легких – единственный радикальный метод лечения заболеваний легких в терминальной стадии дыхательной недостаточности. К 2019 году в мире выполнено 63 530 трансплантаций легких [13]. В силу многообразия заболеваний, приводящих пациентов к пересадке легких, существует широкий спектр различных осложнений и состояний, которые подлежат индивидуальному клиническому подходу для определения тактики лечения. Каждый случай представляет огромный интерес с клинической точки зрения в силу небольшого количества данных операций и сложности послеоперационной реабилитации, требующей мультидисциплинарного подхода [12]. Мы представляем  клиническое наблюдение хирургического лечения экспираторного стеноза трахеи в  сочетании с бронхоэктатической болезнью у пациента после трансплантации легких

Использование криотехнологий в трансплантации легких и сердечно-легочного комплекса

Bronchial complications, along with development and progression of chronic dysfunction on the background of chronic rejection, are factors that reduce the quality and life of lung and heart-lung recipients. They also increase the frequency of hospitalizations. Application of cryotechnology is based on the contact effect of extremely low temperatures on organs and tissues using a cryoprobe. This article demonstrates the experience of using cryotechnology in the diagnosis and treatment of complications in lung and heart-lung recipients.Бронхиальные осложнения наряду с развитием и прогрессированием хронической дисфункции на фоне хронического отторжения являются факторами, снижающими качество и продолжительность жизни реципиентов легких и сердечно-легочного комплекса, а также увеличивающими частоту госпитализаций. В основе применения криотехнологий лежит контактное воздействие чрезвычайно низких температур на органы и ткани с помощью криозонда. В данной статье демонстрируется опыт применения криотехнологий в диагностике и лечении осложнений у реципиентов легких и сердечно-легочного комплекса

Morpholino Gene Knockdown in Adult Fundulus heteroclitus: Role of SGK1 in Seawater Acclimation

The Atlantic killifish (Fundulus heteroclitus) is an environmental sentinel organism used extensively for studies on environmental toxicants and salt (NaCl) homeostasis. Previous research in our laboratory has shown that rapid acclimation of killifish to seawater is mediated by trafficking of CFTR chloride channels from intracellular vesicles to the plasma membrane in the opercular membrane within the first hour in seawater, which enhances chloride secretion into seawater, thereby contributing to salt homeostasis. Acute transition to seawater is also marked by an increase in both mRNA and protein levels of serum glucocorticoid kinase 1 (SGK1) within 15 minutes of transfer. Although the rise in SGK1 in gill and its functional analog, the opercular membrane, after seawater transfer precedes the increase in membrane CFTR, a direct role of SGK1 in elevating membrane CFTR has not been established in vivo. To test the hypothesis that SGK1 mediates the increase in plasma membrane CFTR we designed two functionally different vivo-morpholinos to knock down SGK1 in gill, and developed and validated a vivo-morpholino knock down technique for adult killifish. Injection (intraperitoneal, IP) of the splice blocking SGK1 vivo-morpholino reduced SGK1 mRNA in the gill after transition from fresh to seawater by 66%. The IP injection of the translational blocking and splice blocking vivo-morpholinos reduced gill SGK1 protein abundance in fish transferred from fresh to seawater by 64% and 53%, respectively. Moreover, knock down of SGK1 completely eliminated the seawater induced rise in plasma membrane CFTR, demonstrating that the increase in SGK1 protein is required for the trafficking of CFTR from intracellular vesicles in mitochondrion rich cells to the plasma membrane in the gill during acclimation to seawater. This is the first report of the use of vivo-morpholinos in adult killifish and demonstrates that vivo-morpholinos are a valuable genetic tool for this environmentally relevant model organism

The Support Splitting Algorithm for Induced Codes

In the paper, the analysis of the stability of the McEliece-type cryptosystem on induced codes for key attacks is examined. In particular, a model is considered when the automorphism group is trivial for the base code C, on the basis of which the induced code Flq ⊗ C is constructed. In this case, as shown by N. Sendrier in 2000, there exists such a mapping, called a complete discriminant, by means of which a secret permutation that is part of the secret key of a McEliece-type cryptosystem can be effectively found. The automorphism group of the code Flq ⊗ C is nontrivial, therefore there is no complete discriminant for this code. This suggests a potentially high resistance of the McEliece-type cryptosystem on the code Flq ⊗ C. The algorithm for splitting the support for the code Flq ⊗ C is constructed and the efficiency of this algorithm is compared with the existing attack on the key of the McElice type cryptosystem based on the code Flq ⊗ C