10 research outputs found
PREVENTION OF INTESTINAL ANASTOMOTIC LEAKAGE IN CASE OF PERITONITIS (EXPERIMENTAL RESEARCH)
Background. The problem of development of postoperative complications after operations on the organs of the gastrointestinal tact is extremely important. Failure of intestinal suture, formed in the presence of peritonitis develops from 2.8 to 32 % of patients. Aim. To improve immediate outcomes in the formation of a small intestine anastomosis in conditions of purulent peritonitis. Materials and methods. We conducted immunohistochemical examination of biopsy specimens of the small intestine of 20 patients died of peritonitis and compared the area of the vascular bed in different types of intestinal wall section. The experimental operations were performed in 100 Wistar rats. On the background of established models of peritonitis we performed different variants of small bowel anastomosis, including one with the use of photodynamic therapy. On the 6th day after the surgery, animals were sacrificed, and histological examination of the anastomoses was conducted. Results. Suture strip in the section of the small intestine made at the angle of 60Β° is supplied substantially better than in the section made at the angle of 90Β°. The experiment confirmed that the suggested method of anastomosis showed the best results. Conclusion. When one forms the "end-to-end" anastomosis in the small intestine in conditions of purulent peritonitis, it is reasonable to cross the intestinal wall at the angle of 60Β° and to perform photodynamic therapy on the formed anastomosis
ΠΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠ»ΡΡΠ°ΠΉ ΡΡΠΆΠ΅Π»ΠΎΠ³ΠΎ Π΄Π΅ΡΠΈΡΠΈΡΠ° Π΄Π΅ΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°Π·Ρ Π°ΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ L-Π°ΠΌΠΈΠ½ΠΎΠΊΠΈΡΠ»ΠΎΡ
We present a case of a rare disease, aromatic L-amino acid decarboxylase deficiency (AADCD), with delayed diagnosis even after a pathogenic mutation indicative of AADCD was found. In most cases, AADCD causes marked impairment of motor and psycho- speech development and is accompanied by severe episodes of dystonia β oculogyric crises. The careful attention of neurologists, pediatricians, geneticists, gastroenterologists, and pulmonologists in cases of a complex set of diverse symptoms determines the success of early diagnosis and the earliest possible prescription of modern gene replacement therapy for AADCD.ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ ΡΠ»ΡΡΠ°ΠΉ ΡΠ΅Π΄ΠΊΠΎΠ³ΠΎ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ β Π΄Π΅ΡΠΈΡΠΈΡΠ° Π΄Π΅ΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°Π·Ρ Π°ΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
L-Π°ΠΌΠΈΠ½ΠΎΠΊΠΈΡΠ»ΠΎΡ (aromatic L-amino acid decarboxylase deficiency, AADCD) Ρ Π·Π°Π΄Π΅ΡΠΆΠΊΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π° Π΄Π°ΠΆΠ΅ ΠΏΠΎΡΠ»Π΅ ΡΠΎΠ³ΠΎ, ΠΊΠ°ΠΊ Π±ΡΠ»Π° ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Π° ΠΏΠ°ΡΠΎΠ³Π΅Π½Π½Π°Ρ ΠΌΡΡΠ°ΡΠΈΡ, ΡΠΊΠ°Π·ΡΠ²Π°ΡΡΠ°Ρ Π½Π° AADCD. Π§Π°ΡΠ΅ Π²ΡΠ΅Π³ΠΎ AADCD Π²ΡΠ·ΡΠ²Π°Π΅Ρ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΡΠ΅ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ ΠΌΠΎΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΈ ΠΏΡΠΈΡ
ΠΎΡΠ΅ΡΠ΅Π²ΠΎΠ³ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΈ ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π΅ΡΡΡ ΡΡΠΆΠ΅Π»ΡΠΌΠΈ ΡΠΏΠΈΠ·ΠΎΠ΄Π°ΠΌΠΈ Π΄ΠΈΡΡΠΎΠ½ΠΈΠΈ β ΠΎΠΊΡΠ»ΠΎΠ³ΠΈΡΠ½ΡΠΌΠΈ ΠΊΡΠΈΠ·Π°ΠΌΠΈ. ΠΠ°ΡΡΠΎΡΠΎΠΆΠ΅Π½Π½ΠΎΡΡΡ Π²Π½ΠΈΠΌΠ°Π½ΠΈΡ Π½Π΅Π²ΡΠΎΠ»ΠΎΠ³ΠΎΠ², ΠΏΠ΅Π΄ΠΈΠ°ΡΡΠΎΠ², Π³Π΅Π½Π΅ΡΠΈΠΊΠΎΠ², Π³Π°ΡΡΡΠΎΡΠ½ΡΠ΅ΡΠΎΠ»ΠΎΠ³ΠΎΠ², ΠΏΡΠ»ΡΠΌΠΎΠ½ΠΎΠ»ΠΎΠ³ΠΎΠ² Π² ΡΠ»ΡΡΠ°ΡΡ
ΡΠ»ΠΎΠΆΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° ΡΠ°Π·Π½ΠΎΠΎΠ±ΡΠ°Π·Π½ΡΡ
ΡΠΈΠΌΠΏΡΠΎΠΌΠΎΠ² ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅Ρ ΡΡΠΏΠ΅Ρ
ΡΠ°Π½Π½Π΅ΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΈ ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΠΎ ΡΠ°Π½Π½Π΅Π³ΠΎ Π½Π°Π·Π½Π°ΡΠ΅Π½ΠΈΡ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ Π³Π΅Π½ΠΎΠ·Π°ΠΌΠ΅ΡΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ AADCD