井上円了と自然科学

departmental bulletin pape

Treatment of Surgical Site Infection with Aqua Oxidation Water: Comparison with Povidone Iodine

Aqua oxidation water is a new disinfectant with a bactericidal activity based on high oxidation-reduction potential and acidity. We compared the effectiveness of aqua oxidation water and povidone iodine against the surgical site infection (SSI). The bacteriological effect against several organisms and the efficacy of both disinfectants were almost similar. However, the duration of treatment with aqua oxidation water was shorter than that with the povidone iodine in healed wounds (p<0.05) and the number of patients treated with aqua oxidation water who reported pain was smaller than that with povidone iodine (p<0.05). Our results indicated that aqua oxidation water useful and effective for the treatment of incurable SSI

サイボウ ヒョウソウ コウガク オ リヨウ シタ カンキョウ オウトウセイ ケイコウ タンパクシツ サイボウ ヒョウソウ テイジ ニ カンスル ケンキュウ

京都大学0048新制・課程博士博士(工学)甲第9104号工博第2080号新制||工||1216(附属図書館)UT51-2001-G824京都大学大学院工学研究科合成・生物化学専攻(主査)教授 田中 渥夫, 教授 今中 忠行, 教授 木村 俊作学位規則第4条第1項該当Doctor of EngineeringKyoto UniversityDA

Progress of Molecular Display Technology Using <i>Saccharomyces cerevisiae</i> to Achieve Sustainable Development Goals

In the long history of microorganism use, yeasts have been developed as hosts for producing biologically active compounds or for conventional fermentation. Since the introduction of genetic engineering, recombinant proteins have been designed and produced using yeast or bacterial cells. Yeasts have the unique property of expressing genes derived from both prokaryotes and eukaryotes. Saccharomyces cerevisiae is one of the well-studied yeasts in genetic engineering. Recently, molecular display technology, which involves a protein-producing system on the yeast cell surface, has been established. Using this technology, designed proteins can be displayed on the cell surface, and novel abilities are endowed to the host yeast strain. This review summarizes various molecular yeast display technologies and their principles and applications. Moreover, S. cerevisiae laboratory strains generated using molecular display technology for sustainable development are described. Each application of a molecular displayed yeast cell is also associated with the corresponding Sustainable Development Goals of the United Nations