6,108 research outputs found
Genomic Analyses of the Quinol Oxidases and/or Quinone Reductases Involved in Bacterial Extracellular Electron Transfer
To exchange electrons with extracellular substrates, some microorganisms employ extracellular electron transfer (EET) pathways that physically connect extracellular redox reactions to intracellular metabolic activity. These pathways are made of redox and structural proteins that work cooperatively to transfer electrons between extracellular substrates and the cytoplasmic membrane. Crucial to the bacterial and archaeal EET pathways are the quinol oxidases and/or quinone reductases in the cytoplasmic membrane where they recycle the quinone/quinol pool in the cytoplasmic membrane during EET reaction. Up to date, three different families of quinol oxidases and/or quinone reductases involved in bacterial EET have been discovered. They are the CymA, CbcL/MtrH/MtoC, and ImcH families of quinol oxidases and/or quinone reductases that are all multiheme c-type cytochromes (c-Cyts). To investigate to what extent they are distributed among microorganisms, we search the bacterial as well as archaeal genomes for the homologs of these c-Cyts. Search results reveal that the homologs of these c-Cyts are only found in the Domain Bacteria. Moreover, the CymA homologs are only found in the phylum of Proteobacteria and most of them are in the Shewanella genus. In addition to Shewanella sp., CymA homologs are also found in other Fe(III)-reducing bacteria, such as of Vibrio parahaemolyticus. In contrast to CymA, CbcL/MtrH/MtoC, and ImcH homologs are much more widespread. CbcL/MtrH/MtoC homologs are found in 15 phyla, while ImcH homologs are found in 12 phyla. Furthermore, the heme-binding motifs of CbcL/MtrH/MtoC and ImcH homologs vary greatly, ranging from 3 to 23 and 6 to 10 heme-binding motifs for CbcL/MtrH/MtoC and ImcH homologs, respectively. Moreover, CymA and CbcL/MtrH/MtoC homologs are found in both Fe(III)-reducing and Fe(II)-oxidizing bacteria, suggesting that these families of c-Cyts catalyze both quinol-oxidizing and quinone-reducing reactions. ImcH homologs are only found in the Fe(III)-reducing bacteria, implying that they are only the quinol oxidases. Finally, some bacteria have the homologs of two different families of c-Cyts, which may improve the bacterial capability to exchange electrons with extracellular substrates
Anderson Localization and Mobility Edge in Curved Spacetime
We construct a quasiperiodic lattice model in a curved spacetime to explore
the crossover concerning both condensed matter and curved spacetime physics. We
study the related Anderson localization and find that the model has a clear
boundary of localized-extended phase separation, which leads to the mobility
edge, i.e., the coexistence of nonergodic localized, critical and extended
phases. A novel self-consistent segmentation method is developed to calculate
the analytical expression of the critical position of phase separation, and the
rich phase diagram is determined by calculating the fractal dimension and
scaling index in multifractal analysis.Comment: 17 pages, 4+12 figure
Explicit Visual Prompts for Visual Object Tracking
How to effectively exploit spatio-temporal information is crucial to capture
target appearance changes in visual tracking. However, most deep learning-based
trackers mainly focus on designing a complicated appearance model or template
updating strategy, while lacking the exploitation of context between
consecutive frames and thus entailing the \textit{when-and-how-to-update}
dilemma. To address these issues, we propose a novel explicit visual prompts
framework for visual tracking, dubbed \textbf{EVPTrack}. Specifically, we
utilize spatio-temporal tokens to propagate information between consecutive
frames without focusing on updating templates. As a result, we cannot only
alleviate the challenge of \textit{when-to-update}, but also avoid the
hyper-parameters associated with updating strategies. Then, we utilize the
spatio-temporal tokens to generate explicit visual prompts that facilitate
inference in the current frame. The prompts are fed into a transformer encoder
together with the image tokens without additional processing. Consequently, the
efficiency of our model is improved by avoiding \textit{how-to-update}. In
addition, we consider multi-scale information as explicit visual prompts,
providing multiscale template features to enhance the EVPTrack's ability to
handle target scale changes. Extensive experimental results on six benchmarks
(i.e., LaSOT, LaSOT\rm , GOT-10k, UAV123, TrackingNet, and TNL2K.)
validate that our EVPTrack can achieve competitive performance at a real-time
speed by effectively exploiting both spatio-temporal and multi-scale
information. Code and models are available at
https://github.com/GXNU-ZhongLab/EVPTrack
4-(1-CycloÂpropyl-6-fluoro-4-oxo-1,4-dihydroÂquinolin-7-yl)piperazin-1-ium 2,4,5-tricarbÂoxyÂbenzene-1-carboxylÂate monohydrate
In the crystal of title compound, C16H19FN3O+·C10H5O8
−·H2O, the water molÂecule and the ions are connected by interÂmolecular N—H⋯O and O—H⋯O hydrogen bonds and π–π stacking [centroid–centroid separation = 3.602 (1) Å] between the benzene ring and the pyridine ring, generating a three-dimensional supraÂmolecular structure
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