10,414 research outputs found

    The Margin Abatement Costs of CO2 in Chinese industrial sectors

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    AbstractUsing the directional distance function estimating by a non-parametric method, this paper measured shadow prices indicating the margin abatement costs (MACs) of CO2 emissions of China's industrial sectors. The results show that the MACs are within 0.2 thousand Yuan per ton to 120.3 thousand Yuan per ton, differentiating among sectors. In average, the MACs of heavy and chemical industries are lower than that of light and high-tech industries

    Monoclinic form of (Z)-1-ferrocenyl-3-(3-hy­droxy­anilino)but-2-en-1-one

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    The title compound, [Fe(C5H5)(C15H14NO2)], is a monoclinic polymorph of the previously reported triclinic form [Shi et al. (2006 ▶). Acta Cryst. C62, m407–m410]. The polymorphs feature the same strong intra­molecular N—H⋯O=C hydrogen bonds, but show different packing modes. The mol­ecules in the monoclinic form associate into double chains via O—H⋯O=C and (Cp)C—H⋯O—H inter­actions

    Characterisation of the BRCT/DBL Protein ECT2 in cell cycle regulation

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    Ph.DDOCTOR OF PHILOSOPH

    An Opposite Effect of the CDK Inhibitor, p18<sup>INK4c</sup> on Embryonic Stem Cells Compared with Tumor and Adult Stem Cells

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    Self-renewal is a feature common to both adult and embryonic stem (ES) cells, as well as tumor stem cells (TSCs). The cyclin-dependent kinase inhibitor, p18INK4c, is a known tumor suppressor that can inhibit self-renewal of tumor cells or adult stem cells. Here, we demonstrate an opposite effect of p18 on ES cells in comparison with teratoma cells. Our results unexpectedly showed that overexpression of p18 accelerated the growth of mouse ES cells and embryonic bodies (EB); on the contrary, inhibited the growth of late stage teratoma. Up-regulation of ES cell markers (i.e., Oct4, Nanog, Sox2, and Rex1) were detected in both ES and EB cells, while concomitant down-regulation of various differentiation markers was observed in EB cells. These results demonstrate that p18 has an opposite effect on ES cells as compared with tumor cells and adult stem cells. Mechanistically, expression of CDK4 was significantly increased with overexpression of p18 in ES cells, likely leading to a release of CDK2 from the inhibition by p21 and p27. As a result, self-renewal of ES cells was enhanced. Our current study suggests that targeting p18 in different cell types may yield different outcomes, thereby having implications for therapeutic manipulations of cell cycle machinery in stem cells. © 2012 Li et al

    4-Methyl-7-[2-(1H-1,2,4-triazol-1-yl)eth­oxy]-2H-chromen-2-one

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    In the title mol­ecule, C14H13N3O3, the dihedral angle between the triazole ring and coumarin ring system is 73.01 (4)°. The crystal structure is stabilized by weak inter­molecular C—H⋯N and C—H⋯O hydrogen bonds
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