2,942 research outputs found
Coupled effects of local movement and global interaction on contagion
By incorporating segregated spatial domain and individual-based linkage into
the SIS (susceptible-infected-susceptible) model, we investigate the coupled
effects of random walk and intragroup interaction on contagion. Compared with
the situation where only local movement or individual-based linkage exists, the
coexistence of them leads to a wider spread of infectious disease. The roles of
narrowing segregated spatial domain and reducing mobility in epidemic control
are checked, these two measures are found to be conducive to curbing the spread
of infectious disease. Considering heterogeneous time scales between local
movement and global interaction, a log-log relation between the change in the
number of infected individuals and the timescale is found. A theoretical
analysis indicates that the evolutionary dynamics in the present model is
related to the encounter probability and the encounter time. A functional
relation between the epidemic threshold and the ratio of shortcuts, and a
functional relation between the encounter time and the timescale are
found
Antitumor Efficacy and Mechanism in Hepatoma H22-Bearing Mice of Brucea javanica
Brucea javanica is a traditional herbal medicine in China, and its antitumor activities are of research interest. Brucea javanica oil, extracted with ether and refined with 10% ethyl alcohol from Brucea javanica seed, was used to treat hepatoma H22-bearing mice in this study. The antitumor effect and probable mechanisms of the extracted Brucea javanica oil were studied in H22-bearing mice by WBC count, GOT, GPT levels, and western blotting. The H22 tumor inhibition ratio of 0.5, 1, and 1.5 g/kg bw Brucea javanica oil were 15.64%, 23.87%, and 38.27%. Brucea javanica oil could inhibit the involution of thymus induced by H22 tumor-bearing, but it could not inhibit the augmentation of spleen and liver. Brucea javanica oil could decrease the levels of WBC count and GOT and GPT in H22-bearing mice. The protein levels of GAPDH, Akt, TGF-β1, and α-SMA in tumor tissues decreased after being treated with Brucea javanica oil. Disturbing energy metabolism and neoplastic hyperplasia controlled by Akt and immunoregulation activity were its probable antitumor mechanisms in hepatoma H22-bearing mice
A generalized public goods game with coupling of individual ability and project benefit
Facing a heavy task, any single person can only make a limited contribution
and team cooperation is needed. As one enjoys the benefit of the public goods,
the potential benefits of the project are not always maximized and may be
partly wasted. By incorporating individual ability and project benefit into the
original public goods game, we study the coupling effect of the four
parameters, the upper limit of individual contribution, the upper limit of
individual benefit, the needed project cost and the upper limit of project
benefit on the evolution of cooperation. Coevolving with the individual-level
group size preferences, an increase in the upper limit of individual benefit
promotes cooperation while an increase in the upper limit of individual
contribution inhibits cooperation. The coupling of the upper limit of
individual contribution and the needed project cost determines the critical
point of the upper limit of project benefit, where the equilibrium frequency of
cooperators reaches its highest level. Above the critical point, an increase in
the upper limit of project benefit inhibits cooperation. The evolution of
cooperation is closely related to the preferred group-size distribution. A
functional relation between the frequency of cooperators and the dominant group
size is found
Mediastinal Lymph Node Metastases in Thyroid Cancer: Characteristics, Predictive Factors, and Prognosis
Background. Mediastinal lymph node metastases (MLNM) have not been extensively studied. The aim of this study is to investigate the characteristics, predictive factors, and prognosis of MLNM in thyroid cancer. Methods. This is a retrospective study based on the thyroid cancer patients with MLNM at our institution from 2008 to 2015. Results. In total, 73 thyroid cancer patients with positive MLNM were included in this study. It contained sixty patients (82.2%) with papillary thyroid carcinoma (PTC), twelve (16.4%) with medullary thyroid carcinoma, and one (1.4%) with anaplastic thyroid carcinoma. Forty-eight patients had the surgery as initial treatment. Fifty-three (72.6%) patients remained disease-free, and fifteen (20.5%) developed a regional recurrence. Distant metastases occurred in four (5.5%) patients and five (6.8%) patients died. Five-year overall survival rate and disease-free survival (DFS) rate of the PTC patients for initial treatment are 95.4% and 77.2%, respectively. Extrathyroidal extension and multiple lymph nodes involved were associated with DFS in PTC patients. Conclusions. Initial therapeutic control is very important for the thyroid cancer patients. Extrathyroidal extension and multiple mediastinal lymph nodes involved were the influence factors of prognosis in the thyroid cancer patients with MLNM
Electroacupuncture Ameliorates Acute Lung Injury through Promoting Gastrointestinal Motility in Rats with Acute Pancreatitis
Objective. Gastrointestinal disfunction and acute lung injury (ALI) were common in acute pancreatitis (AP). The effect of electro-acupuncture (EA) on gastrointestinal motility and ALI in rats with AP was investigated to verify the theory of “lung and large intestine are interior exteriorly related” in traditional Chinese medicine. Methods. Male Sprague-Dawley rats were randomly divided into the normal group, model group, and EA group. AP model was established by three injections of 20% L-arginine at 1 h intervals. EA were applied to bilateral ST-25 and ST-36 for 30 minutes twice a day after modeling for 3 days. Arterial blood, pancreas, lung, and intestinal tissues were collected for detecting the inflammatory factors and histopathology. Intestinal propulsion rate (IPR) was also measured at 72 h. Results. EA treatment improved IPR and increased CCK-8 level compared with model group (P < 0.05). It lowered the serum levels of TNF-α and IL-6 and increased the level of IL-4 with no effect on IL-10. EA treatment reduced serum vasoactive intestinal peptide (VIP) and myeloperoxidase (MPO) level in the lung and the pathologic scores of pancreas, lung and intestine were decreased (P < 0.05). Conclusion. EA treatment could promote gastrointestinal motility through inhibiting VIP, and promoting CCK expression and regulate pro- and anti-inflammatory mediators to ameliorate ALI in AP
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