Interleukin-6 in cardiac surgery

Background and Purpose: Interleukin (IL)-6 is a multi-functional pro- and anti-inflammatory cytokine, and it has been a reliable biomarker of cardiac function status and myocardial damage. However, the characteristics of IL-6 expressions in the cardiac surgical patients have not been comprehensively described. The purpose of this review is to present the current knowledge on the role of IL-6 in the field of cardiac surgery.Materials and Methods: Medical literature of IL-6 in cardiac surgical disorders of recent 3 decades were carefully collected as studying materials, and comprehensively reviewed and analyzed.Results: Plasma IL-6 was significantly elevated 1 hour and peaked 3-6 hours after the start of cardiopulmonary bypass with a gradual decrease constant maintenance thereafter. No significant differences were found between patients with biological and mechanical heart valve replacements between on-poump and off-pump coronary artery bypass, or between cyanotic and acyanotic congental heart patients. The elevation of IL-6 was higher in mitral valve replacement than in coronary artery bypass grafting patients and in non-heart transplantation than heart transplantation patients. Il-6 was involved in the pathogenesis of pulmonary artery hypertension and infective endocarditis, and predicted adverse cardiac events, such as coronary graft occlusion, aortic dissection progression, and cardiac myxoma recurrence.Conclusions: In cardiac surgical patients, the expression of IL-6 reflects the inflammatory situation of the patients and also predicts their prognosis. The higher elevation of IL-6 in mitral valve replacement and in non-heart transplantation might be attributed to cardiotomy suction, and to lack of sterioid use. Early administrations with steroid, α2-adrenergic agonists, incretin hormones, or ischemic conditioning could reduce the inflammatory response and prevent from pertinent postoperative complications. Anesthetic agents and technique of choices may also reduce immune reactions and lower circulating cytokines. Extracorporeal IL-6 removal facilities have been successfully applied in clinical practice. The potential alternative therapies with IL-6 antibodies might be further developed and used in such patients for preventing myocardial apoptotic processes.</p

Repression of Germline RNAi Pathways in Somatic Cells by Retinoblastoma Pathway Chromatin Complexes

The retinoblastoma (Rb) tumor suppressor acts with a number of chromatin cofactors in a wide range of species to suppress cell proliferation. The Caenorhabditis elegans retinoblastoma gene and many of these cofactors, called synMuv B genes, were identified in genetic screens for cell lineage defects caused by growth factor misexpression. Mutations in many synMuv B genes, including lin-35/Rb, also cause somatic misexpression of the germline RNA processing P granules and enhanced RNAi. We show here that multiple small RNA components, including a set of germline-specific Argonaute genes, are misexpressed in the soma of many synMuv B mutant animals, revealing one node for enhanced RNAi. Distinct classes of synMuv B mutants differ in the subcellular architecture of their misexpressed P granules, their profile of misexpressed small RNA and P granule genes, as well as their enhancement of RNAi and the related silencing of transgenes. These differences define three classes of synMuv B genes, representing three chromatin complexes: a LIN-35/Rb-containing DRM core complex, a SUMO-recruited Mec complex, and a synMuv B heterochromatin complex, suggesting that intersecting chromatin pathways regulate the repression of small RNA and P granule genes in the soma and the potency of RNAi. Consistent with this, the DRM complex and the synMuv B heterochromatin complex were genetically additive and displayed distinct antagonistic interactions with the MES-4 histone methyltransferase and the MRG-1 chromodomain protein, two germline chromatin regulators required for the synMuv phenotype and the somatic misexpression of P granule components. Thus intersecting synMuv B chromatin pathways conspire with synMuv B suppressor chromatin factors to regulate the expression of small RNA pathway genes, which enables heightened RNAi response. Regulation of small RNA pathway genes by human retinoblastoma may also underlie its role as a tumor suppressor gene

Shenqi fuzheng, an injection concocted from chinese medicinal herbs, combined with platinum-based chemotherapy for advanced non-small cell lung cancer: a systematic review

<p>Abstract</p> <p>Background</p> <p>Platinum-based chemotherapy has been a standard therapy for advanced non-small cell lung cancer (NSCLC), but it has high toxicity. In China, Shenqi Fuzheng, a newly developed injection concocted from Chinese medicinal herbs has been reported that may increase efficacy and reduce toxicity when combined with platinum-based chemotherapy, but little is known about it outside of China. The aim of this study was to systematically review the existing clinical evidence on Shenqi Fuzheng Injection(SFI) combined with platinum-based chemotherapy for advanced NSCLC.</p> <p>Methods</p> <p>Pubmed, Cochrane Library, EMBASE, CNKI, and CBM search were organized for all documents published, in English and Chinese, until April 2010. The randomized controlled clinical trials were selected based on specific criteria, in which a SFI plus platinum-based chemotherapy treatment group was compared with a platinum-based chemotherapy control group for patients with advanced NSCLC. The quality of studies was assessed by modified Jadad's scale, and Revman 4.2 software was used for data syntheses and analyses.</p> <p>Results</p> <p>Twenty nine studies were included in this review based on our selection criteria. Of them, ten studies were of high quality and the rest were of low quality, according to the modified Jadad scale. The meta-analysis showed there was a statistically significant higher tumor response (RR, 1.19; 95% CI, 1.07 to 1.32; P = 0.001) and performance status ((RR, 1.57; 95% CI, 1.45 to 1.70; P < 0.00001); but lower severe toxicity for WBC (RR, 0.37; 95% CI, 0.29 to 0.47; P < 0.00001), PLT (RR, 0.33; 95% CI, 0.21 to 0.52; P < 0.00001), HB (RR, 0.44; 95% CI, 0.30 to 0.66; P < 0.0001) and nausea and vomiting (RR, 0.32; 95% CI, 0.22 to 0.47; P < 0.00001), when the SFI plus platinum-based chemotherapy treatment group was compared with the platinum-based chemotherapy control group. Sensitivity analysis was restricted to studies with the high quality, and the result was similar when the studies with low quality were excluded. Asymmetry was observed in a funnel plot analysis, and Egger's test also indicated an evidence of publication bias (<it>P </it>= 0.016).</p> <p>Conclusions</p> <p>SFI intervention appears to be useful to increase efficacy and reduce toxicity when combined with platinum-based chemotherapy for advanced NSCLC, although this result needs to be further verified by more high-quality trials.</p

Dimethyl­ammonium perchlorate 18-crown-6 monohydrate clathrate

The reaction of dimethyl­amine, 18-crown-6, and perchloric acid in methanol yields the title compound, C2H8N+·ClO4 −·C12H24O6·H2O. The dimethyl­ammonium cation and the water mol­ecule inter­act with the 18-crown-6 unit: N—H⋯O hydrogen bonds are formed between the ammonium NH2 + group and four O atoms of the crown ether, while the water mol­ecule on the other side of 18-crown-6 ring forms O—H⋯O hydrogen bonds with two other O atoms of the crown ether. All conventional donors and acceptors in the cations are thus engaged in hydrogen bonding. The ClO4 − anion is disordered over two sites, and occupancies for the disordered O atoms were fixed at 0.5. In the crystal, the cations and anions are arranged in alternating layers

A Survey on Extreme Multi-label Learning

Multi-label learning has attracted significant attention from both academic and industry field in recent decades. Although existing multi-label learning algorithms achieved good performance in various tasks, they implicitly assume the size of target label space is not huge, which can be restrictive for real-world scenarios. Moreover, it is infeasible to directly adapt them to extremely large label space because of the compute and memory overhead. Therefore, eXtreme Multi-label Learning (XML) is becoming an important task and many effective approaches are proposed. To fully understand XML, we conduct a survey study in this paper. We first clarify a formal definition for XML from the perspective of supervised learning. Then, based on different model architectures and challenges of the problem, we provide a thorough discussion of the advantages and disadvantages of each category of methods. For the benefit of conducting empirical studies, we collect abundant resources regarding XML, including code implementations, and useful tools. Lastly, we propose possible research directions in XML, such as new evaluation metrics, the tail label problem, and weakly supervised XML.Comment: A preliminary versio

[2,9-Bis(3,5-dimethyl-1H-pyrazol-1-yl-κN 2)-1,10-phenanthroline-κ2 N,N′](methanol-κO)(nitrito-κ2 O,O′)cadmium(II) perchlorate

In the title complex, [Cd(NO2)(C22H20N6)(CH3OH)]ClO4, the CdII ion is in a distorted penta­gonal–bipyramidal CdN4O3 coordination geometry. The dihedral angles formed between the mean planes of the pyrazole rings and the phenanthroline ring system are 4.37 (19) and 5.84 (21)°. In the crystal, the anions and cations are connected by inter­molecular O—H⋯O hydrogen bonding, while pairs of weak inter­molecular C—H⋯O hydrogen bonds connect the cations into centrosymmetric dimers. In addition, there is a π–π stacking inter­action involving two symmetry-related benzene rings, with a centroid–centroid distance of 3.437 (3) Å

NADPH Oxidase 1 and Its Derived Reactive Oxygen Species Mediated Tissue Injury and Repair

Reactive oxygen species are mostly viewed to cause oxidative damage to various cells and induce organ dysfunction after ischemia-reperfusion injury. However, they are also considered as crucial molecules for cellular signal transduction in biology. NADPH oxidase, whose only function is reactive oxygen species production, has been extensively investigated in many cell types especially phagocytes. The deficiency of NADPH oxidase extends the process of inflammation and delays tissue repair, which causes chronic granulomatous disease in patients. NADPH oxidase 1, one member of the NADPH oxidase family, is not only constitutively expressed in a variety of tissues, but also induced to increase expression in both mRNA and protein levels under many circumstances. NADPH oxidase 1 and its derived reactive oxygen species are suggested to be able to regulate inflammation reaction, cell proliferation and migration, and extracellular matrix synthesis, which contribute to the processes of tissue injury and repair

SATformer: Transformer-Based UNSAT Core Learning

This paper introduces SATformer, a novel Transformer-based approach for the Boolean Satisfiability (SAT) problem. Rather than solving the problem directly, SATformer approaches the problem from the opposite direction by focusing on unsatisfiability. Specifically, it models clause interactions to identify any unsatisfiable sub-problems. Using a graph neural network, we convert clauses into clause embeddings and employ a hierarchical Transformer-based model to understand clause correlation. SATformer is trained through a multi-task learning approach, using the single-bit satisfiability result and the minimal unsatisfiable core (MUC) for UNSAT problems as clause supervision. As an end-to-end learning-based satisfiability classifier, the performance of SATformer surpasses that of NeuroSAT significantly. Furthermore, we integrate the clause predictions made by SATformer into modern heuristic-based SAT solvers and validate our approach with a logic equivalence checking task. Experimental results show that our SATformer can decrease the runtime of existing solvers by an average of 21.33%